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    METHODS AND APPARATUS FOR EXPRESSING BODY FLUID FROM AN INCISION
    3.
    发明申请
    METHODS AND APPARATUS FOR EXPRESSING BODY FLUID FROM AN INCISION 审中-公开
    用于从体内表达体液的方法和装置

    公开(公告)号：US20110046515A1

    公开(公告)日：2011-02-24

    申请号：US12938784

    申请日：2010-11-03

    Applicant: Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    Inventor： Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    IPC: A61B5/151

    CPC classification number: A61B5/15194 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15111 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2562/0295

    Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

    Abstract translation: 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的形成凹陷的身体组织的环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。

    Methods and apparatus for expressing body fluid from an incision
    4.
    发明授权
    Methods and apparatus for expressing body fluid from an incision 有权
    用于从切口表达体液的方法和装置

    公开(公告)号：US06319210B1

    公开(公告)日：2001-11-20

    申请号：US09586969

    申请日：2000-06-05

    Applicant: Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    Inventor： Joel S. Douglas ,  Jeffrey N. Roe ,  Henry M. Grage

    IPC: A61B500

    CPC classification number: A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150412 ,  A61B5/15109 ,  A61B5/15117 ,  A61B5/15186 ,  A61B5/15194 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2562/0295

    Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

    Abstract translation: 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的凹陷的身体组织环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。

    Opaque reaction matrix for the analysis of the whole blood
    9.
    发明授权
    Opaque reaction matrix for the analysis of the whole blood 失效
    不透明反应矩阵用于分析全血

    公开(公告)号：US5968765A

    公开(公告)日：1999-10-19

    申请号：US961942

    申请日：1997-10-31

    Applicant: Henry M. Grage ,  Joel S. Douglas ,  Pat S. Lee

    Inventor： Henry M. Grage ,  Joel S. Douglas ,  Pat S. Lee

    IPC: B01D69/14 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/50 ,  G01N33/52 ,  C12Q1/00

    CPC classification number: G01N33/52 ,  B01D69/141 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/5002 ,  G01N33/521 ,  Y10S435/968 ,  Y10S435/97

    Abstract: A test strip for use in determining the presence or concentration of an analyte in whole blood is disclosed. The test strip is a porous membrane having disposed thereon (a) a separating agent capable of separating from whole blood, red blood cells and a fluid component substantially free of red blood cells; (b) an indicating reagent system capable of indicating the presence or concentration of an analyte in the fluid component by producing a spectrophotometric change upon contact with the fluid component; and (c) an opaque filler capable of reducing spectrophotometric interference caused by the presence of the red blood cells. Also disclosed are methods of testing whole blood for the presence or concentration of an analyte using the test strip.

    Abstract translation: 公开了一种用于确定全血中分析物的存在或浓度的测试条。 测试条是其上设置有多孔膜（a）能够从全血，红细胞和基本上不含红细胞的流体组分分离的分离剂; （b）指示试剂系统，其能够通过在与流体组分接触时产生分光光度变化来指示流体组分中分析物的存在或浓度; 和（c）能够减少由红细胞存在引起的分光光度干扰的不透明填料。 还公开了使用测试条测试全血的分析物的存在或浓度的方法。

    Test carrier and method for the analytical determination of components of body fluids
    10.
    发明授权
    Test carrier and method for the analytical determination of components of body fluids 失效
    用于分析体内液体组分的测试载体和方法

    公开(公告)号：US5104811A

    公开(公告)日：1992-04-14

    申请号：US134950

    申请日：1987-12-18

    Applicant: Dieter Berger ,  Wolfgang-Reinhold Knappe ,  Robert Lorenz ,  Henry M. Grage, Jr. ,  Mark T. Skarstedt ,  Bernward Sojka ,  Manfred Bleisteiner

    Inventor： Dieter Berger ,  Wolfgang-Reinhold Knappe ,  Robert Lorenz ,  Henry M. Grage, Jr. ,  Mark T. Skarstedt ,  Bernward Sojka ,  Manfred Bleisteiner

    IPC: G01N31/22 ,  C12M1/34 ,  G01N21/77 ,  G01N33/49 ,  G01N33/52 ,  G01N33/543 ,  G01N33/558

    CPC classification number: G01N33/525 ,  G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S436/81

    Abstract: On a carrier layer there are arranged several test layers which are at least partly in fluid contact with one another, enabling liquid exchange. On the carrier layer are arranged an application zone, a detection zone for the production of a detectable signal characteristic of the analytical determination, which contains at least one said test layer which is a reaction layer, and an absorption zone with a test layer which is an absorptive layer of an absorbent material, wherein the reaction layer and absorption zone are positioned next to each other. Between the application and the absorption zone is a capillary-active transport path on the carrier layer which connects the application zone and the absorption zone. The reaction layer is arranged parallel to the transport path between the application zone and the absorption zone in such a manner that it is in liquid contact with a liquid transported in the transport path. The absorption zone therefore absorbs excess liquid and permits dosing the reaction layer with a reproducible amount of sample.

    Abstract translation: 在载体层上布置有几个测试层，其至少部分地彼此流体接触，从而实现液体交换。 在载体层上布置有应用区域，用于产生分析测定特征的可检测信号的检测区域，其包含至少一个作为反应层的测试层，以及具有测试层的吸收区，其为 吸收材料的吸收层，其中反应层和吸收区彼此相邻放置。 在应用和吸收区之间是在载体层上的连接施加区和吸收区的毛细管 - 主动传输路径。 反应层以与输送路径中输送的液体液体接触的方式平行于施加区域和吸收区域之间的输送路径布置。 因此，吸收区吸收多余的液体，并允许用可重复量的样品给反应层。

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