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    Identifying, monitoring, and treating women for breast precancer or cancer
    2.
    发明申请
    Identifying, monitoring, and treating women for breast precancer or cancer 审中-公开
    识别，监测和治疗乳腺癌前期癌症或癌症的妇女

    公开(公告)号：US20070161063A1

    公开(公告)日：2007-07-12

    申请号：US11713495

    申请日：2007-03-02

    Applicant: Susan Love ,  David Hung ,  Hui Cen

    Inventor： Susan Love ,  David Hung ,  Hui Cen

    IPC: G01N33/574

    CPC classification number: A61K31/4535 ,  A61K31/00 ,  A61K31/138 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/566 ,  C12Q1/6886 ,  G01N33/5091 ,  G01N33/57415 ,  G01N2333/723 ,  A61K2300/00

    Abstract: The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.

    Abstract translation: 本发明是通过测定雌激素相关标志物的水平来筛选乳腺癌和癌前期妇女的方法。 本发明还提供了治疗被鉴定为具有一种或多种异常导管上皮细胞和雌激素相关标志物的患者的方法。 本发明提供了用于筛选患者激素替代疗法（HRT）的方法，以及一旦开始HRT就监测这些患者。 本发明提供治疗绝经期或绝经后妇女的方法，用于癌症风险降低和绝经症状（或与降低的系统性雌激素水平相关的其它病症）。 本发明还提供了用于所述的筛选，监测和处理方法的试剂盒。

    Methods of generating gene-specific probes for nucleic acid array detection
    3.
    发明申请
    Methods of generating gene-specific probes for nucleic acid array detection 审中-公开
    生成用于核酸阵列检测的基因特异性探针的方法

    公开(公告)号：US20050095600A1

    公开(公告)日：2005-05-05

    申请号：US10700304

    申请日：2003-10-31

    Applicant: Xiang Yu ,  Li Shen ,  Xiao Zeng ,  Ying Han ,  Kun Lu ,  Hui Cen

    Inventor： Xiang Yu ,  Li Shen ,  Xiao Zeng ,  Ying Han ,  Kun Lu ,  Hui Cen

    IPC: C12P19/34 ,  C12Q1/68

    CPC classification number: C12Q1/6837 ,  C12Q2565/513 ,  C12Q2531/113 ,  C12Q2531/107

    Abstract: This invention provides gene-specific probe labeling methods for nucleic acid array detection. In the subject invention, a set of a representational number of distinct gene specific primers is used to generate a sub-population of labeled nucleic acids from each of the different physiological samples. The labeled nucleic acids are then compared to each other by hybridizing to a specially designed nucleic acid array that contains the representational number of distinct genes. The subject methods find use in identifying the expression pattern of the genes of special interest in the physiological samples.

    Abstract translation: 本发明提供用于核酸阵列检测的基因特异性探针标记方法。 在本发明中，使用一组不同的基因特异性引物的代表数量来产生来自不同生理样品中每一种的标记核酸的亚群。 然后通过与包含不同基因的代表性数量的特别设计的核酸阵列杂交，将标记的核酸彼此进行比较。 主题方法用于鉴定生理样品中特别感兴趣的基因的表达模式。

    EGFH2 genes and gene products
    4.
    发明授权
    EGFH2 genes and gene products 失效
    EGFH2基因和基因产物

    公开(公告)号：US06825333B1

    公开(公告)日：2004-11-30

    申请号：US09640041

    申请日：2000-08-15

    Applicant: W. Michael Kavanaugh ,  Hui Cen ,  Pauline Lee

    Inventor： W. Michael Kavanaugh ,  Hui Cen ,  Pauline Lee

    IPC: C07H2104

    CPC classification number: C07K14/4756 ,  A61K38/00

    Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.

    Abstract translation: 本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

    .gamma. II adaptin
    5.
    发明授权
    .gamma. II adaptin 失效
    γII适应症

    公开(公告)号：US6165733A

    公开(公告)日：2000-12-26

    申请号：US861745

    申请日：1997-05-22

    Applicant: Hui Cen ,  Lewis T. Williams

    Inventor： Hui Cen ,  Lewis T. Williams

    IPC: C07K14/47 ,  C12N9/12 ,  C12N15/12 ,  C12Q1/00 ,  C07K14/46 ,  C12N15/62

    CPC classification number: C12N9/1205 ,  C07K14/47 ,  C07K2319/00

    Abstract: A mammalian protein involved in receptor-mediated endocytosis specifically binds to phosphatidylinositol 3-kinase. More specifically it binds to the Bcr homology domain of the p85 subunit of phosphatidylinositol 3-kinase. Phathoidylinositol 3-kinase also binds to platelet derived growth factor receptor. Other receptors may also bind, including those for insulin, insulin-like growth factor-1, colony stimulating factor 1, nerve growth factor, hepatocyte growth factor, stem cell growth factor, and epidermal growth factor. Mitogenesis is the consequence of the binding and internalization of these growth factors. Inhibition of the process of receptor-mediated internalization inhibits mitogenesis.

    Abstract translation: 参与受体介导的内吞作用的哺乳动物蛋白质特异性结合磷脂酰肌醇3-激酶。 更具体地说，它结合磷脂酰肌醇3-激酶的p85亚基的Bcr同源结构域。 Phathoidylinositol 3-kinase也与血小板衍生生长因子受体结合。 其他受体也可能结合，包括胰岛素，胰岛素样生长因子-1，集落刺激因子1，神经生长因子，肝细胞生长因子，干细胞生长因子和表皮生长因子。 有丝分裂是这些生长因子的结合和内化的结果。 受体介导的内化过程的抑制抑制有丝分裂。

    Enzyme substrate comprising a functional dye and associated technology and methods
    6.
    发明授权
    Enzyme substrate comprising a functional dye and associated technology and methods 有权
    酶底物包含功能染料及相关技术和方法

    公开(公告)号：US08586325B2

    公开(公告)日：2013-11-19

    申请号：US13891406

    申请日：2013-05-10

    Applicant: Fei Mao ,  Hui Cen

    Inventor： Fei Mao ,  Hui Cen

    IPC: C12Q1/37 ,  A61K38/14 ,  C07D279/08

    CPC classification number: C12N9/96 ,  C07D263/60 ,  C07D417/06 ,  C07D501/00 ,  C07K7/06 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/485 ,  G01N21/6486 ,  G01N33/582

    Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

    Abstract translation: 提供了本发明的酶底物和相关技术。 本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。 酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。 通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。 因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物 ，或疾病的诊断。

    Enzyme substrate comprising a functional dye and associated technology and methods
    7.
    发明授权
    Enzyme substrate comprising a functional dye and associated technology and methods 有权
    酶底物包含功能染料及相关技术和方法

    公开(公告)号：US08092784B2

    公开(公告)日：2012-01-10

    申请号：US12095322

    申请日：2006-11-21

    Applicant: Fei Mao ,  Hui Cen ,  Wai-yee Leung

    Inventor： Fei Mao ,  Hui Cen ,  Wai-yee Leung

    IPC: A61B10/00 ,  C12Q1/68

    CPC classification number: C12N9/96 ,  C07D263/60 ,  C07D417/06 ,  C07D501/00 ,  C07K7/06 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/485 ,  G01N21/6486 ,  G01N33/582

    Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

    Abstract translation: 提供了本发明的酶底物和相关技术。 本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。 酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。 通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。 因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物 ，或疾病的诊断。

    ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS
    9.
    发明申请
    ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权

    公开(公告)号：US20130236888A1

    公开(公告)日：2013-09-12

    申请号：US13891406

    申请日：2013-05-10

    Applicant: Fei Mao ,  Hui Cen

    Inventor： Fei Mao ,  Hui Cen

    IPC: G01N21/64 ,  C07K7/06 ,  C07D501/00 ,  C07D417/06

    CPC classification number: C12N9/96 ,  C07D263/60 ,  C07D417/06 ,  C07D501/00 ,  C07K7/06 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/485 ,  G01N21/6486 ,  G01N33/582

    Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

    ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS
    10.
    发明申请
    ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权
    包含功能性染色及其相关技术和方法的酶基质

    公开(公告)号：US20090148386A1

    公开(公告)日：2009-06-11

    申请号：US12095322

    申请日：2006-11-21

    Applicant: Fei Mao ,  Hui Cen ,  Wai-yee Leung

    Inventor： Fei Mao ,  Hui Cen ,  Wai-yee Leung

    IPC: A61B10/00 ,  C12Q1/68 ,  G01N33/573

    CPC classification number: C12N9/96 ,  C07D263/60 ,  C07D417/06 ,  C07D501/00 ,  C07K7/06 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/485 ,  G01N21/6486 ,  G01N33/582

    Abstract: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

    Abstract translation: 提供了本发明的酶底物和相关技术。 本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。 酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。 通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。 因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物 ，或疾病的诊断。

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