公开(公告)号：US08965480B2

公开(公告)日：2015-02-24

申请号：US13641458

申请日：2011-04-14

Applicant: Youngkyoo Jung ,  Kun Lu

Inventor： Youngkyoo Jung ,  Kun Lu

IPC: A61B5/055 ,  A61B5/026 ,  G01R33/563

CPC classification number: A61B5/0263 ,  G01R33/56366

Abstract: Techniques and systems are disclosed for measuring arterial transit delay using pseudo- continuous arterial spin labeling (ASL) with variable TR and interleaved post-labeling delays. In one aspect, a magnetic resonance imaging method for measure arterial blood flow and transit delay using arterial spin labeling (ASL) includes applying an ASL pulse sequence. The ASL pulse sequence includes a pre- saturation pulse, and a labeling pulse. The method includes performing data acquisition to measure a transit delay, which represents a time needed for labeled blood to arrive in an imaging slice.

Abstract translation: 公开了用于使用具有可变TR和交错的后标记延迟的伪连续动脉自旋标记（ASL）测量动脉转移延迟的技术和系统。 一方面，使用动脉自旋标记（ASL）测量动脉血流量和传递延迟的磁共振成像方法包括应用ASL脉冲序列。 ASL脉冲序列包括预饱和脉冲和标记脉冲。 该方法包括执行数据采集以测量传输延迟，其表示标记血液到达成像切片所需的时间。

公开(公告)号：US20080058276A1

公开(公告)日：2008-03-06

申请号：US11623672

申请日：2007-01-16

Applicant: Kun LU ,  Linda NICHOLSON ,  Lucia PASTORINO ,  Xiao ZHOU ,  Soumya DE

Inventor： Kun LU ,  Linda NICHOLSON ,  Lucia PASTORINO ,  Xiao ZHOU ,  Soumya DE

IPC: A61K31/70 ,  A61P25/28 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/00

CPC classification number: A61K31/70 ,  G01N33/6896 ,  G01N2800/2821

Abstract: The present invention is directed to inhibiting amyloidogenic processing of amyloid precursor protein, and/or inhibiting production of amyloid beta peptides. These methods can involve accelerating cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or contacting a cell with a compound that mimics the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein. The present invention also relates to treating and/or preventing in a subject a degenerative neurological disease characterized by amyloidogenic processing of amyloid precursor protein and/or overproduction of amyloid beta peptide. This method involves administering an agent that accelerates cis/trans isomerization of amyloid precursor protein at a phosphorylated serine/threonine-proline motif and/or inhibits production of amyloid β peptides. Methods of screening for therapeutic agents effective in treating and/or preventing such diseases, methods of screening for biological molecules involved in the amyloidogenic pathway, and compounds that mimic the cis conformation of a phosphorylated serine/threonine-proline motif of an amyloid precursor protein are also disclosed.

Abstract translation: 本发明涉及抑制淀粉样蛋白前体蛋白的淀粉样蛋白形成加工和/或抑制淀粉样蛋白β肽的产生。 这些方法可以涉及在磷酸化丝氨酸/苏氨酸 - 脯氨酸基序上加速淀粉样蛋白前体蛋白的顺式/反式异构化和/或使细胞与模拟淀粉样蛋白前体蛋白的磷酸化丝氨酸/苏氨酸 - 脯氨酸基序的顺式构象的化合物接触 。 本发明还涉及在受试者中治疗和/或预防退行性神经疾病，其特征在于淀粉样蛋白前体蛋白的淀粉样蛋白生成加工和/或淀粉样蛋白β肽的过量产生。 该方法包括施用在磷酸化丝氨酸/苏氨酸 - 脯氨酸基序上加速淀粉样蛋白前体蛋白的顺式/反式异构化的试剂和/或抑制淀粉状蛋白β肽的产生。 筛选有效治疗和/或预防此类疾病的治疗剂的方法，筛选参与淀粉样蛋白生成途径的生物分子的方法，以及模拟淀粉样蛋白前体蛋白的磷酸化丝氨酸/苏氨酸 - 脯氨酸基序的顺式构象的化合物是： 也披露。

公开(公告)号：US20070042467A1

公开(公告)日：2007-02-22

申请号：US11585649

申请日：2006-10-23

Applicant: Tony Hunter ,  Kun Lu

Inventor： Tony Hunter ,  Kun Lu

IPC: C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC classification number: C12Y502/01008 ,  A61K38/00 ,  C12N9/90

Abstract: A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

Abstract translation: 提供了一类新颖的NIMA相互作用蛋白（PIN），由Pin1举例说明。 Pin1诱导G2停滞，并延迟NIMA诱导的有丝分裂过度表达，并在耗尽时触发有丝分裂停滞和DNA断裂。 还提供了鉴定其他Pin蛋白和Pin相互作用蛋白质并鉴定影响Pin活性或表达的组合物的方法。

公开(公告)号：US07121854B2

公开(公告)日：2006-10-17

申请号：US11041538

申请日：2005-01-24

Applicant: William C. Buck ,  Kenneth M. Brazell ,  Chris Lewis ,  Taku Ohi ,  George Michael Hornick ,  Feng Kun Lu ,  Xiao Ping Liu

Inventor： William C. Buck ,  Kenneth M. Brazell ,  Chris Lewis ,  Taku Ohi ,  George Michael Hornick ,  Feng Kun Lu ,  Xiao Ping Liu

IPC: H01R13/62

CPC classification number: H01M2/1022 ,  B25F5/02

Abstract: A battery ejection mechanism for ejecting a battery housing removably attached to an electrical device housing. The mechanism includes at least two ejection members, each having a button and an arm. The arms are adapted to transfer a force applied on the buttons to the electrical device housing to provide a pushing force for ejection of the battery pack from the electrical device housing. Force on the buttons also causes associated latches on the battery pack to move to their release position.

Abstract translation: 一种电池弹出机构，用于喷射可移除地附接到电气装置壳体上的电池壳体。 该机构包括至少两个排出构件，每个具有按钮和臂。 臂适于将施加在按钮上的力传递到电气装置壳体，以提供用于将电池组从电气装置壳体排出的推力。 按钮上的强制也会导致电池组上相关的闩锁移动到其释放位置。

公开(公告)号：US20060185776A1

公开(公告)日：2006-08-24

申请号：US11345083

申请日：2006-01-31

Applicant: Kun Lu

Inventor： Kun Lu

IPC: B60C11/13

CPC classification number: B60C11/0302 ,  B60C11/13 ,  B60C2011/0374 ,  B60C2011/1361

Abstract: A pneumatic tire comprising a plurality of wishbone shaped patterns, each comprising a first substantially inclined circumferential groove and a second substantially inclined circumferential groove; and a plurality of curved, substantially lateral grooves, wherein each first substantially inclined circumferential groove and each second substantially inclined circumferential groove is intersected by at least one substantially lateral groove, and each of the inclined circumferential and lateral grooves is perpendicular with the turning axis of the tire.

Abstract translation: 一种充气轮胎，包括多个叉形图案，每个包括第一基本上倾斜的周向槽和第二基本上倾斜的周向槽; 以及多个弯曲的基本上横向的凹槽，其中每个第一基本上倾斜的周向凹槽和每个第二基本上倾斜的周向凹槽由至少一个基本上横向的凹槽相交，并且每个倾斜的周向和横向凹槽与 轮胎。

公开(公告)号：US20050282740A1

公开(公告)日：2005-12-22

申请号：US11022308

申请日：2004-12-21

Applicant: Kun Lu ,  Xiao Zhou

Inventor： Kun Lu ,  Xiao Zhou

IPC: G01N33/50 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K38/52 ,  A61K45/00 ,  A61K47/48 ,  A61P25/28 ,  A61P35/00 ,  C07K14/47 ,  C12N5/06 ,  C12N9/90 ,  C12N9/99 ,  G01N33/15 ,  G01N33/566

CPC classification number: G01N33/68 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/52 ,  A61K47/62 ,  C07K14/47 ,  C12N9/90 ,  G01N33/6872 ,  G01N2500/02

Abstract: The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.

Abstract translation: 本发明涉及作为磷酸丝氨酸和磷酸苏氨酸结合模块的WW-结构域的方法和组合物。 含有WW结构域的本发明的多肽可用于例如调节细胞生长; 治疗神经退行性疾病; 筛选调节含有WW结构域的多肽和磷酸化配体之间相互作用的物质; 作为药物靶向车辆; 引导蛋白质降解; 以及治疗特征为异常WW-结构域的多肽或其配体的某些疾病或病症。

公开(公告)号：US20050147608A1

公开(公告)日：2005-07-07

申请号：US10840827

申请日：2004-05-07

Applicant: Akihide Ryo ,  Kun Lu

Inventor： Akihide Ryo ,  Kun Lu

IPC: A61K39/395 ,  A61K48/00 ,  C12N20060101 ,  C12N9/64 ,  C12N9/90 ,  G01N33/53 ,  G01N33/567

CPC classification number: C12N9/90 ,  C12N2310/14 ,  C12Y502/01008

Abstract: The instant invention pertains to the discovery of two novel regulatory mechanisms of NF-kB. The instant invention demonstrates that NF-kB is regulated by Pin1-catalyzed prolyl isomerization and ubiquitin-mediated proteolysis of p65. Accordingly, the instant invention provides methods for regulating NF-kB, and diseases and disorders associated with NF-kB. Further, the invention provides compositions capable of modulating the activity or expression of NF-kB, Pin1, and/or the proteolysis of p65.

Abstract translation: 本发明涉及NF-kB两种新的调节机制的发现。 本发明证明NF-kB受Pin1催化的脯氨酰异构化和泛素介导的p65蛋白水解的调节。 因此，本发明提供了调节NF-kB以及与NF-kB相关的疾病和病症的方法。 此外，本发明提供能够调节NF-kB，Pin1和/或p65的蛋白水解的活性或表达的组合物。

公开(公告)号：US06452787B1

公开(公告)日：2002-09-17

申请号：US09414564

申请日：1999-10-08

Applicant: Yu-Kun Lu ,  Chuan-Yuan Lee ,  Yu-Tsai Chang ,  Chia-Ling Wu

Inventor： Yu-Kun Lu ,  Chuan-Yuan Lee ,  Yu-Tsai Chang ,  Chia-Ling Wu

IPC: H05K710

CPC classification number: G06F1/1613 ,  G06F1/1656

Abstract: An engaging and ejecting device for expansion module/cell of portable computer, including a control member and a switch member pivotally disposed on one side of a housing of the portable computer. The control member and the switch member drivingly cooperate with each other. One side of the expansion module is disposed with a block body. After the module is inserted into the portable computer housing, the control member, switch member and control block drivingly cooperate with each other to engage the module inside the computer housing. When the switch member is pushed outward, the module is ejected out of the computer housing.

Abstract translation: 一种用于便携式计算机的扩展模块/单元的接合和排出装置，包括控制构件和枢转地设置在便携式计算机的壳体的一侧上的开关构件。 控制构件和开关构件彼此驱动配合。 扩展模块的一侧设置有块体。 在将模块插入便携式计算机外壳之后，控制构件，开关构件和控制块相互驱动地配合以将模块接合在计算机外壳内部。 当开关构件向外推时，将模块从计算机外壳中弹出。

公开(公告)号：US08584233B1

公开(公告)日：2013-11-12

申请号：US12115388

申请日：2008-05-05

Applicant: Liulin Yang ,  Kun Lu ,  Shiyu Xie

Inventor： Liulin Yang ,  Kun Lu ,  Shiyu Xie

IPC: G06F11/00

CPC classification number: G06F21/51 ,  G06F21/56 ,  G06F2221/2119 ,  H04L63/145

Abstract: Providing malware-free web content to a user is disclosed. The web content is any type of web content that may potentially be infected by any type of malware. Upon receiving a request for a piece of web content from the user, the requested piece of web content is obtained from the appropriate source, and a dynamic template for the piece of web content is retrieved. The dynamic template indicates whether the requested piece of web content includes any malware and what actions are to be performed if any malware is included in the piece of web content. The requested piece of web content is cleaned up by performing the actions indicated in the dynamic template. Thereafter, the piece of web content is provided to the user. The dynamic template is updated from time to time based on the currently available information regarding the piece of web content.

Abstract translation: 公开了向用户提供无恶意软件的网页内容。 网页内容是可能被任何类型的恶意软件感染的任何类型的网页内容。 在从用户接收到一个网页内容的请求时，从适当的来源获得所请求的网页内容，并且检索用于该网页内容的动态模板。 动态模板指示所请求的网页内容是否包含任何恶意软件，以及如果任何恶意软件包含在该网页内容中，将执行什么操作。 通过执行动态模板中指示的操作来清除所请求的网页内容。 此后，该网页内容被提供给用户。 动态模板根据当前可用的有关该网页内容的信息不时更新。

公开(公告)号：US20110231256A1

公开(公告)日：2011-09-22

申请号：US12842934

申请日：2010-07-23

Applicant: Wu Wang ,  Mei Marker ,  Kun Lu ,  Haijun Cao ,  Hong Yao ,  Wei Wang

Inventor： Wu Wang ,  Mei Marker ,  Kun Lu ,  Haijun Cao ,  Hong Yao ,  Wei Wang

IPC: G06Q30/00

CPC classification number: G06Q30/02 ,  G06Q30/0255

Abstract: A method for generating a behavioral model for a targeted advertisement category (TAC), including: obtaining click stream data including ad-clicks and events preceding the ad-clicks and performed on web pages; assigning features having categories and keywords associated with the web pages to the events; identifying an ad-click of the ad-clicks and a subset of the events preceding the ad-click that result in the ad-click, where the subset of the events is associated with at least one feature; generating an aggregated event sequence by aggregating the ad-click and the subset of the events; selecting, in response to the at least one feature being associated with the TAC, a training data set including at least the aggregated event sequence; generating the behavioral model for the TAC by applying a learning algorithm to a portion of the training data set; and evaluating performance of built models and select model based on performance result.

Abstract translation: 一种用于生成目标广告类别（TAC）的行为模型的方法，包括：获得包括广告点击和广告点击之前在网页上执行的事件的点击流数据; 将具有与所述网页相关联的类别和关键字的特征分配给所述事件; 识别广告点击的广告点击和导致广告点击的广告点击之前的一小部分事件，其中事件的子集与至少一个要素相关联; 通过聚合广告点击和事件的子集来生成聚合事件序列; 响应于所述至少一个与所述TAC相关联的特征，选择至少包括所述聚合事件序列的训练数据集; 通过将学习算法应用到训练数据集的一部分来生成TAC的行为模型; 并根据性能结果评估内置模型的性能和选择模型。