公开(公告)号：US20070218056A1

公开(公告)日：2007-09-20

申请号：US11705277

申请日：2007-02-12

Applicant: Susan Love ,  Julian Nikolchev ,  David Hung

Inventor： Susan Love ,  Julian Nikolchev ,  David Hung

IPC: A61K39/395

CPC classification number: A61K49/1812

Abstract: The invention provides methods of identifying premalignant and malignant breast cancer, determining lymph node involvement in patients diagnosed with premalignant and malignant breast cancer growths, and methods of treating premalignant and malignant breast cancer. The diagnostic and methods comprise intraductal administration of a targeting molecule either alone acting as an identifying agent, or coupled to an identifying agent; the therapeutic methods comprise intraductal administration of a targeting molecule coupled to a therapeutic agent or administration of a targeting molecule having therapeutic activity in and of itself.

Abstract translation: 本发明提供了鉴定癌前期和恶性乳腺癌的方法，确定诊断为恶变前和恶性乳腺癌生长的患者的淋巴结受累，以及治疗癌前期和恶性乳腺癌的方法。 诊断和方法包括单独用作鉴定试剂或偶联至鉴定试剂的靶向分子的导管内施用; 治疗方法包括与治疗剂偶联的靶向分子的管内施用或其本身具有治疗活性的靶向分子的给药。

公开(公告)号：US06642010B2

公开(公告)日：2003-11-04

申请号：US09502404

申请日：2000-02-10

Applicant: Susan Love ,  David Hung ,  Hui Cen

Inventor： Susan Love ,  David Hung ,  Hui Cen

IPC: G01N33574

CPC classification number: A61K31/4535 ,  A61K31/00 ,  A61K31/138 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/566 ,  C12Q1/6886 ,  G01N33/5091 ,  G01N33/57415 ,  G01N2333/723 ,  A61K2300/00

Abstract: The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.

Abstract translation: 本发明是通过测定雌激素相关标志物的水平来筛选乳腺癌和癌前期妇女的方法。 本发明还提供了治疗被鉴定为具有一种或多种异常导管上皮细胞和雌激素相关标志物的患者的方法。 本发明提供了用于筛选患者激素替代疗法（HRT）的方法，以及一旦开始HRT就监测这些患者。 本发明提供治疗绝经期或绝经后妇女的方法，用于癌症风险降低和绝经症状（或与降低的系统性雌激素水平相关的其它病症）。 本发明还提供了用于所述的筛选，监测和处理方法的试剂盒。

公开(公告)号：US20150258271A1

公开(公告)日：2015-09-17

申请号：US14523123

申请日：2014-10-24

Applicant: DR. SUSAN LOVE RESEARCH FOUNDATION

Inventor： Susan Love

IPC: A61M5/00 ,  A61K49/22 ,  A61N5/10 ,  A61K9/00

CPC classification number: A61M5/007 ,  A61B5/055 ,  A61B5/4312 ,  A61B6/12 ,  A61B6/481 ,  A61B6/502 ,  A61B8/0825 ,  A61B8/085 ,  A61B8/481 ,  A61B8/483 ,  A61N5/10 ,  A61N5/1039

Abstract: According to some embodiments, a method of evaluating an extent of intraductal disease in a breast of a subject comprises identifying a target duct of the breast of a subject, wherein the target duct comprises or is likely to comprise at least one abnormality, accessing the target duct through a corresponding ductal orifice of the breast using at least one access device, delivering a volume of a fluid within the target duct and imaging the breast using an imaging device to visualize and evaluate the extent of intraductal disease of the target duct.

Abstract translation: 根据一些实施例，一种评估受试者乳腺中导管内疾病程度的方法包括识别受试者的乳房的目标导管，其中所述目标导管包括或可能包括至少一个异常，进入所述靶 通过使用至少一个进入装置的乳房的相应导管孔导管，在目标导管内传送一定体积的流体并使用成像装置成像乳房，以使目标导管的导管内疾病的程度可视化和评估。

公开(公告)号：US20150209238A1

公开(公告)日：2015-07-30

申请号：US14498652

申请日：2014-09-26

Applicant: Dr. Susan Love Research Foundation

Inventor： Daniel R. Kurz ,  Lynn Seely

IPC: A61J13/00 ,  A61M19/00

CPC classification number: A61J13/00 ,  A61F13/141 ,  A61F15/008 ,  A61F2013/15016 ,  A61M19/00 ,  A61M2210/1007

Abstract: One aspect of the present invention relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body. This prevents the cover from being noticed while it is worn under clothing. The cover can contain a medicament or agent for pretreating a portion of the body before an examination or procedure. When the cover is used to apply a topical anesthetic to a portion of the body for a recommended period of time prior to the procedure or examination commencing, the amount of discomfort experienced by the patient can be significantly reduced compared to the amount experienced by the patient who has the anesthetic applied for just a few moments before the procedure begins. Alternatively, the cover can be used to hold a medicament or agent on the intended portion of the body in order to heal a wound or cure a condition such as a skin rash or the like.

Abstract translation: 本发明的一个方面涉及一种用于患者身体的突出部分的覆盖部件。 该盖子是柔性的并且可折叠的，使得其符合身体的包裹部分的形状。 这样可以防止在衣服穿着时注意盖子。 盖子可以包含用于在检查或程序之前预处理身体的一部分的药物或试剂。 当在手术或检查开始之前使用盖子将局部麻醉剂施用于身体的一部分建议的时间段时，与患者经历的量相比，可以显着降低患者的不适量 在手术开始之前麻醉药物只需要几分钟就可以使用。 或者，盖可以用于将药物或药剂保持在身体的预期部分上，以便愈合伤口或治愈诸如皮疹等的状况。

公开(公告)号：US20140273007A1

公开(公告)日：2014-09-18

申请号：US14204848

申请日：2014-03-11

Applicant: DR. SUSAN LOVE RESEARCH FOUNDATION

Inventor： Susan Love

IPC: G01N33/574

CPC classification number: G01N33/57415 ,  G01N2800/50

Abstract: A diagnostic test system, apparatus and method for identifying individuals at risk for developing or having breast cancer by detection of at least one marker associated with increased breast cancer risk in nipple aspirate fluid is provided. A testing device for screening nipple aspirate fluid for the presence of biomarkers associated with breast cancer and methods of identifying individual biomarkers and biomarker panels for evaluating the risk that an individual has developed or will develop breast cancer by assaying nipple aspirate fluid is described.

Abstract translation: 提供了一种诊断测试系统，装置和方法，用于通过检测与乳头抽吸液中增加的乳腺癌风险相关联的至少一个标记来识别处于发展或患有乳腺癌的风险中的个体。 描述了用于筛选乳头抽吸液的测试装置，用于存在与乳腺癌相关的生物标志物，以及鉴定个体生物标志物和生物标志物组的方法，以评估个体通过测定乳头抽吸液而发展或将发展乳腺癌的风险。

公开(公告)号：US20130129616A1

公开(公告)日：2013-05-23

申请号：US13659819

申请日：2012-10-24

Applicant: Annette Bianchi ,  Julian Nikolchev ,  David Hung ,  Eyal Ron ,  Linda K. Gont ,  Susan Love ,  Tina Patel

Inventor： Annette Bianchi ,  Julian Nikolchev ,  David Hung ,  Eyal Ron ,  Linda K. Gont ,  Susan Love ,  Tina Patel

IPC: A61K9/00

CPC classification number: A61K9/0041 ,  A61B17/54 ,  A61B2017/320008 ,  A61K31/765 ,  A61K41/0023 ,  A61K41/0042 ,  A61K45/06 ,  A61K47/10 ,  A61K49/0043 ,  A61K49/006 ,  A61K49/0073 ,  A61K49/0433

Abstract: The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or nearly all of a breast milk duct prior to surgical excision of breast tissue, and method of identifying part or all of a breast duct or ducts as a surgical aide to a breast surgeon. Kits to support these methods and including these compositions are also provided.

Abstract translation: 本发明是用于在手术切除包括癌性损伤的乳腺组织之前递送至母乳管的凝胶组合物。 本发明还提供了在手术切除乳房组织之前绘制所有或几乎所有母乳管的方法，以及将乳腺导管或导管的部分或全部识别为乳房外科医生的手术辅助器的方法。 还提供了用于支持这些方法并包括这些组合物的试剂盒。

公开(公告)号：US20110010220A1

公开(公告)日：2011-01-13

申请号：US12878583

申请日：2010-09-09

Applicant: Robert BURNHAM ,  Cliff HOWARD ,  Susan LOVE ,  Paul MADSEN ,  John RISHEA

Inventor： Robert BURNHAM ,  Cliff HOWARD ,  Susan LOVE ,  Paul MADSEN ,  John RISHEA

IPC: G06F9/46

CPC classification number: G06Q10/109 ,  G06Q10/1095 ,  H04L67/18 ,  H04L67/325 ,  H04W4/02 ,  H04W4/027 ,  H04W4/18

Abstract: An automatic appointment reminder system uses location and/or direction of travel of the reminder recipient relative to appointments to affect the time of sending of appointment reminders to the user, and thus enhances the user's ability to be on-time for appointments.

Abstract translation: 自动约会提醒系统使用提醒接收者的相对于约会的位置和/或旅行方向来影响向用户发送约会提醒的时间，从而增强了用户准时进行约会的能力。

公开(公告)号：US20070161063A1

公开(公告)日：2007-07-12

申请号：US11713495

申请日：2007-03-02

Applicant: Susan Love ,  David Hung ,  Hui Cen

Inventor： Susan Love ,  David Hung ,  Hui Cen

IPC: G01N33/574

CPC classification number: A61K31/4535 ,  A61K31/00 ,  A61K31/138 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/566 ,  C12Q1/6886 ,  G01N33/5091 ,  G01N33/57415 ,  G01N2333/723 ,  A61K2300/00

Abstract: The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.

Abstract translation: 本发明是通过测定雌激素相关标志物的水平来筛选乳腺癌和癌前期妇女的方法。 本发明还提供了治疗被鉴定为具有一种或多种异常导管上皮细胞和雌激素相关标志物的患者的方法。 本发明提供了用于筛选患者激素替代疗法（HRT）的方法，以及一旦开始HRT就监测这些患者。 本发明提供治疗绝经期或绝经后妇女的方法，用于癌症风险降低和绝经症状（或与降低的系统性雌激素水平相关的其它病症）。 本发明还提供了用于所述的筛选，监测和处理方法的试剂盒。

公开(公告)号：US06629936B2

公开(公告)日：2003-10-07

申请号：US09852145

申请日：2001-05-10

Applicant: David Hung ,  Susan Love

Inventor： David Hung ,  Susan Love

IPC: A61B500

CPC classification number: A61B5/4312 ,  A61B5/4288 ,  A61B10/0041 ,  A61B10/0045

Abstract: Differentiating breast ducts for cancer risk status is a key element in a procedure to screen women for breast cancer. The 6 to 9 breast ducts on the human breast can be differentiated to identify those of higher risk for cancer. The higher risk ducts merit access and analysis of the ductal fluid and monitoring and/or treatment.

Abstract translation: 区分乳腺癌的癌症风险状况是筛查妇女乳腺癌的一个重要因素。 可以区分人乳房上6至9个乳腺导管，以识别癌症风险较高的乳腺管。 较高风险的导管可以获得和分析导管液，监测和/或治疗。

公开(公告)号：US20100256464A1

公开(公告)日：2010-10-07

申请号：US12600245

申请日：2008-05-13

Applicant: Susan Love ,  Jan Wan

Inventor： Susan Love ,  Jan Wan

IPC: A61B10/00

CPC classification number: A61B10/0045 ,  A61B2010/0006

Abstract: A cost-effective and sensitive apparatus and method for detecting individuals at risk for developing or having breast cancer is provided. More particularly, an apparatus and method for detecting markers associated with breast cancer risk is provided in one embodiment. The apparatus and method use nipple aspirate fluid obtained from breast ducts. This nipple aspirate fluid is applied to a marker panel that tests for the presence of specific markers associated with breast cancer risk. The apparatus and method provide a positive response based upon the detection of at least one marker associated with an increased risk for developing or having breast cancer.

Abstract translation: 提供了一种用于检测处于发展中或患有乳腺癌的风险中的个体的成本有效和敏感的装置和方法。 更具体地，在一个实施方案中提供了用于检测与乳腺癌风险相关的标志物的装置和方法。 该装置和方法使用从乳房导管获得的乳头抽吸液。 将该乳头抽吸液施用于标记物组，其测试与乳腺癌风险相关的特定标志物的存在。 所述装置和方法基于检测与发展或患有乳腺癌的风险增加相关联的至少一个标记物提供阳性反应。