公开(公告)号：US07550584B2

公开(公告)日：2009-06-23

申请号：US11390986

申请日：2006-03-27

Applicant: Arun K. Bahl ,  Sharon V. Vercellotti ,  John R. Vercellotti ,  Elias Klein

Inventor： Arun K. Bahl ,  Sharon V. Vercellotti ,  John R. Vercellotti ,  Elias Klein

IPC: C07H1/06 ,  C07H1/08

CPC classification number: A61K33/06 ,  A61K31/592 ,  A61K31/715 ,  A61K33/16 ,  A61K33/22 ,  A61K2300/00

Abstract: The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone growth is desirable. In the invention methods beta glucans are administered so as to enhance the development of osteoblasts and the inhibition of the development and recruitment of osteoclasts. The inhibition of the recruitment and development of osteoclasts, coupled with the enhancement of osteoblast maturation by beta glucans leads to decreased bone resorption and increased bone formation, making beta glucans ideal agents for the treatment of osteoporosis and other bone resorption diseases.

Abstract translation: 本发明提供使用β葡聚糖来治疗与骨丢失或低骨密度相关的病症的方法以及在需要增强骨生长的情况下促进骨生长的方法。 在本发明中，施用β-葡聚糖以增强成骨细胞的发育和抑制破骨细胞的发育和募集。 抑制破骨细胞的募集和发育，加上β葡聚糖的成骨细胞成熟的增强导致骨吸收减少和骨形成增加，使β葡聚糖治疗骨质疏松症和其他骨吸收疾病的理想剂量。

公开(公告)号：US4051300A

公开(公告)日：1977-09-27

申请号：US662010

申请日：1976-02-27

Applicant: Elias Klein ,  James K. Smith ,  Frederick C. Morton

Inventor： Elias Klein ,  James K. Smith ,  Frederick C. Morton

IPC: B01D67/00 ,  B01D69/08 ,  D01D5/24 ,  B05D3/00 ,  D02G3/22

CPC classification number: D01D5/24 ,  B01D67/003 ,  B01D69/08 ,  B01D2323/12 ,  Y10T428/2975

Abstract: Hollow synthetic fibers useful in reverse osmosis, ultrafiltration, gas separation and the like, having high hydraulic permeability to the solvent and capable of operation at pressures from 600 psi and up, are prepared by forming a solution of a fiber-forming polymer in a suitable solvent, adding to the solution a second polymer soluble in the solvent but with limited compatibility with the first polymer when their total concentration increases on coagulation, extruding the resulting solution through an orifice equipped for coaxial extrusion so that coagulating fluid within tube flow results, precipitating with a liquid which is miscible with the solvent for the fiber-forming material, is a non-solvent for the first polymer and a solvent for the second, contacting the extruded solution with the precipitating liquid either coaxially through the extrusion device or by passing the extrudate through the precipitating liquid, and finally washing the resulting hollow fiber free of residual solvents and non-solvents, and air drying. The coagulating fluid and the precipitating liquid may be the same material. The coagulating fluid may be air or another gas.

公开(公告)号：US2601300A

公开(公告)日：1952-06-24

申请号：US64910346

申请日：1946-02-20

Applicant: ELIAS KLEIN

Inventor： ELIAS KLEIN

IPC: B06B1/06

CPC classification number: B06B1/0629

公开(公告)号：US2472107A

公开(公告)日：1949-06-07

申请号：US7807136

申请日：1936-05-06

Applicant: HAYES HARVEY C ,  ELIAS KLEIN

Inventor： HAYES HARVEY C ,  ELIAS KLEIN

IPC: G01S1/72

CPC classification number: G01S1/72 ,  Y10S181/402

公开(公告)号：US2416324A

公开(公告)日：1947-02-25

申请号：US9093736

申请日：1936-07-16

Applicant: ELIAS KLEIN

Inventor： ELIAS KLEIN

IPC: G10K11/02

CPC classification number: G10K11/02 ,  Y10S181/402

公开(公告)号：US06833060B2

公开(公告)日：2004-12-21

申请号：US09850540

申请日：2001-05-07

Applicant: George Harding ,  Elias Klein ,  Jon Klein

Inventor： George Harding ,  Elias Klein ,  Jon Klein

IPC: G01N27453

CPC classification number: G01N27/44704 ,  G01N27/44773

Abstract: The present invention relates generally to the electrophoretic separation of biomolecules, including but not limited to proteins, peptides, DNA and RNA. The methods of this invention are particularly useful when applied to two-dimensional gel electrophoresis.

Abstract translation: 本发明一般涉及生物分子的电泳分离，包括但不限于蛋白质，肽，DNA和RNA。 当应用于二维凝胶电泳时，本发明的方法特别有用。

公开(公告)号：US5911880A

公开(公告)日：1999-06-15

申请号：US573085

申请日：1995-12-15

Applicant: Elias Klein ,  Natarajan Balachander

Inventor： Elias Klein ,  Natarajan Balachander

IPC: B01D67/00 ,  B01D71/68 ,  B01D39/00

CPC classification number: B01D69/08 ,  B01D67/0011 ,  B01D71/68 ,  B01D71/80 ,  C08L71/02 ,  C08L81/06 ,  B01D2325/08 ,  B01D2325/12 ,  B01D2325/36 ,  B01D71/52 ,  C08L2205/05

Abstract: A water wettable permselective membrane for use in hemodialysis, ultrafiltration and microfiltration applications and a device containing the same are provided. The membrane having the above properties comprises a hydrophobic-base polymer, such as a polysulfone or polyethersulfone polymer, and a block copolymer additive wherein one of the blocks of the copolymer additive is a hydrophilic polymer and the other block is a hydrophobic polymer that is analogous in structure to the hydrophobic-base polymer.

Abstract translation: 提供了用于血液透析，超滤和微滤应用的水可湿性渗透选择性膜和含有其的装置。 具有上述性质的膜包括疏水基聚合物，例如聚砜或聚醚砜聚合物，以及嵌段共聚物添加剂，其中共聚物添加剂的嵌段之一是亲水性聚合物，另一嵌段是类似的疏水性聚合物 在结构上与疏水基聚合物。

公开(公告)号：US5869444A

公开(公告)日：1999-02-09

申请号：US701547

申请日：1991-05-15

Applicant: Elias Klein

Inventor： Elias Klein

IPC: A61M1/14 ,  A61K31/195 ,  A61K35/20 ,  A61K35/22 ,  A61K38/00 ,  A61K38/01 ,  A61M1/28 ,  A61P3/00 ,  B01D61/02 ,  B01D61/30 ,  B01D61/58 ,  A01N37/18 ,  A23C9/12 ,  C12P21/06

CPC classification number: A61K38/018 ,  A61M1/287 ,  Y10S530/833

Abstract: This invention relates to a peritoneal dialysis solution which comprises as an osmotically active agent an osmotically effective amount of a mixture of peptides, the mixture consisting substantially of peptides having a molecular weight of about 300 to about 2000 daltons, and an equivalent weight between about 150 to about 1500.

Abstract translation: 本发明涉及一种腹膜透析溶液，其包含作为渗透活性剂的渗透有效量的肽混合物，所述混合物基本上由分子量为约300至约2000道尔顿的肽组成，当量重量为约150 至约1500。

公开(公告)号：US5053133A

公开(公告)日：1991-10-01

申请号：US477512

申请日：1990-02-09

Applicant: Elias Klein ,  Pamela A. Feldhoff

Inventor： Elias Klein ,  Pamela A. Feldhoff

IPC: B01D15/08 ,  B01D67/00 ,  B01D69/14 ,  B01J20/28 ,  B01J47/12 ,  C08G69/48 ,  C08J5/22 ,  C08J9/36 ,  G01N33/548

CPC classification number: B01D67/0093 ,  B01D69/141 ,  B01J20/28033 ,  B01J20/3242 ,  B01J20/3274 ,  B01J20/328 ,  G01N33/548

Abstract: Affinity membranes are prepared by activation of polyamide microporous films. In particular, the films are activated with 1,1'-carbonyldiimidazole, 2-fluoro-1-methylpyridinium.sup.(+) toluene-4-sulfonate.sup.(-), trichlorotriazine, or derivatives thereof, followed by binding of ligand to the activated sites. The polyamide microporous activated films include composite films comprising polyamide covalently bound to a polyhydroxyl compound such as a polysaccharide.

公开(公告)号：US5039420A

公开(公告)日：1991-08-13

申请号：US568041

申请日：1990-08-16

Applicant: Elias Klein ,  Lalith K. Silva

Inventor： Elias Klein ,  Lalith K. Silva

IPC: B01D71/42 ,  C12N11/08

CPC classification number: B01D71/76 ,  C12N11/08 ,  B01D71/40 ,  B01D71/42

Abstract: Hydrophilic semipermeable membranes based on copolymers of acrylonitrile and hydroxy-C.sub.2 -C.sub.4 -alkyl esters of (meth)acrylic acid are provided. The membranes have a substantial water regain at equilibrium, a wide range of ultrafiltration rates, and low solute adsorption by ion-exchange or hydrophobic interaction mechanisms. The membranes are particularly suitable for processing protein containing fluids, especially biological fluids such as blood or plasmas.

Abstract translation: 提供了基于丙烯腈与（甲基）丙烯酸的羟基-C 2 -C 4烷基酯的共聚物的亲水半透膜。 膜在平衡时具有显着的水回收率，宽范围的超滤速率，以及通过离子交换或疏水相互作用机理的低溶质吸附。 该膜特别适用于加工含蛋白质的流体，特别是生物流体如血液或等离子体。