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公开(公告)号：US08642513B2
公开(公告)日：2014-02-04
申请号：US11990974
申请日：2006-09-14
IPC分类号： C07K16/00
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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2.发明授权Human binding molecules having killing activity against enterococci and uses thereof 有权具有针对肠球菌的杀伤活性的人结合分子及其用途公开(公告)号：US07960518B2
公开(公告)日：2011-06-14
申请号：US12227116
申请日：2007-06-05
CPC分类号： C07K16/1271 , A61K38/00 , A61K39/40 , A61K2039/505 , C07K16/1267 , C07K16/18 , C07K2317/21 , G01N33/56911
摘要： The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
摘要翻译： 本发明提供了特异性结合肠球菌并具有针对肠球菌的杀伤活性的人结合分子，编码人结合分子的核酸分子，包含人结合分子的组合物以及鉴定或产生人结合分子的方法。 人结合分子可用于诊断，预防和/或治疗由肠球菌引起的病症。
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公开(公告)号：US20090054254A1
公开(公告)日：2009-02-26
申请号：US11990974
申请日：2006-09-14
CPC分类号： C12N15/1093 , C07K16/005 , C07K16/1018 , C07K16/1275 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C40B40/02
摘要： The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
摘要翻译： 本发明涉及免疫球蛋白文库的产生以及鉴定和产生具有特定功能的免疫球蛋白。
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4.发明申请HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA VIRUS H5N1 AND USES THEREOF 有权能够中和流感病毒H5N1的人结合分子及其用途公开(公告)号：US20120276115A1
公开(公告)日：2012-11-01
申请号：US13458964
申请日：2012-04-27
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 描述了结合分子，例如结合流感病毒H5N1的人单克隆抗体，并具有针对流感病毒H5N1的中和活性。 还描述了编码抗体的核酸分子和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在某些实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗H5，H2，H6，H9和H1基于流感亚型的感染。
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5.发明申请HUMAN BINDING MOLECULES HAVING KILLING ACTIVITY AGAINST STAPHYLOCOCCI AND USES THEREOF 有权具有杀伤生物活性的人结合分子及其用途公开(公告)号：US20120141493A1
公开(公告)日：2012-06-07
申请号：US13397606
申请日：2012-02-15
IPC分类号： A61K39/40 , C12P21/08 , A61P31/04 , C12N5/10 , C07H21/04 , C12N1/15 , C12N1/19 , C12N15/63 , C07K16/00 , G01N33/53 , C12N1/21
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77
摘要： Described are human binding molecules specifically binding to staphylococci and having killing activity against staphylococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Staphylococcus.
摘要翻译： 描述了特异性结合葡萄球菌并具有针对葡萄球菌的杀伤活性，编码人结合分子的核酸分子，包含人结合分子的组合物和鉴定或产生人结合分子的方法的人结合分子。 人结合分子可用于诊断，预防和/或治疗由葡萄球菌产生的病症。
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公开(公告)号：US20120093823A1
公开(公告)日：2012-04-19
申请号：US13315475
申请日：2011-12-09
IPC分类号： A61K39/395 , C07K16/10 , A61P31/16 , C07H21/04
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
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公开(公告)号：US08106170B2
公开(公告)日：2012-01-31
申请号：US11667640
申请日：2005-11-10
申请人： Jan Henrik Ter Meulen , Edward Norbert Van Den Brink , Cornelis Adriaan De Kruif , Jaap Goudsmit
发明人： Jan Henrik Ter Meulen , Edward Norbert Van Den Brink , Cornelis Adriaan De Kruif , Jaap Goudsmit
IPC分类号： C07K16/00 , C12Q1/00 , G01N33/563
CPC分类号： C07K16/10 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76
摘要： The present invention provides compositions of binding molecules specifically binding to a coronavirus such as SARS-CoV and capable of neutralizing an infection caused by the virus. The compositions are suitable for diagnosing, preventing and/or treating a condition resulting from a coronavirus such as SARS-CoV.
摘要翻译： 本发明提供了特异性结合冠状病毒如SARS-CoV的结合分子的组合物，并且能够中和由病毒引起的感染。 该组合物适用于诊断，预防和/或治疗冠状病毒如SARS-CoV引起的病症。
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公开(公告)号：US20090017521A1
公开(公告)日：2009-01-15
申请号：US11977954
申请日：2007-10-26
IPC分类号： C12N7/00
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/10021 , C12N2795/10022
摘要： The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.
摘要翻译： 本发明涉及产生辅助噬菌体和用于鉴定结合分子的噬菌体展示文库的领域。 本发明提供具有包含蛋白质混合物的衣服的嵌合噬菌体。 蛋白质混合物包含具有融合到噬菌体外壳蛋白的功能形式的蛋白质分子和噬菌体外壳蛋白的突变形式的融合蛋白，其中所述突变形式在与宿主细胞受体结合中受损。 本发明还提供了新的噬菌体集合，新颖的辅助噬菌体以及用于产生嵌合噬菌体，感染性噬菌体和辅助噬菌体的方法和手段。
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9.发明申请公开(公告)号：US20080226652A1
公开(公告)日：2008-09-18
申请号：US11978742
申请日：2007-10-29
申请人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
发明人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
摘要翻译： 提供特异性结合狂犬病病毒并能够中和病毒的结合分子。 还提供了编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。 结合分子可用于诊断，预防和/或治疗由狂犬病病毒引起的病症。 在某些实施方案中，它们可以用于狂犬病的暴露后预防。
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10.发明授权Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof 有权能够中和流感病毒H5N1的人结合分子及其用途公开(公告)号：US08691223B2
公开(公告)日：2014-04-08
申请号：US13315475
申请日：2011-12-09
IPC分类号： A61K39/395 , A61K39/42 , C12N7/00
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2760/00011 , C12N2760/00061 , C12N2760/16011 , C12N2760/16061 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
摘要翻译： 描述了结合分子，例如结合流感病毒H5N1的人单克隆抗体，并具有针对流感病毒H5N1的中和活性。 还描述了编码抗体的核酸分子和包含抗体的组合物以及鉴定或产生抗体的方法。 抗体可用于诊断，预防和/或治疗流感病毒H5N1感染。 在某些实施方案中，抗体在体内提供跨亚型保护，使得可以预防和/或治疗H5，H2，H6，H9和H1基于流感亚型的感染。
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