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    systems and methods for performing magnetic chromatography assays
    3.
    发明授权
    systems and methods for performing magnetic chromatography assays 有权
    用于进行磁性色谱分析的系统和方法

    公开(公告)号：US6136549A

    公开(公告)日：2000-10-24

    申请号：US418864

    申请日：1999-10-15

    申请人： Christopher C. Feistel

    发明人： Christopher C. Feistel

    IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N33/558 ,  G01N33/53

    CPC分类号： G01N33/54333 ,  G01N33/558 ,  Y10S435/803 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/806 ,  Y10S436/824

    摘要： Novel magnetic assay methods and systems, as well as systems for conducting spectrophotometric analysis therewith. According to a preferred embodiment, the magnetic assay methods and systems incorporate a chromatographic medium, such as an assay test strip, that is designed to be contacted with a test solution having activated magnetic particles. A magnetic field, generated by a magnet or electromagnet, is additionally provided that if selectively applied to a chromatographic medium which causes the charged particles to become substantially bound at a site all in the chromatographic medium specified by the position of the magnets, to thus form a captured line or zone. To the degree of magnetic force applied to the medium may be selectively adjusted to vary the width or surface area of the capture line or zone. Additionally, in a preferred embodiment, capture lines may be formed while test strips are in motion along a stationary magnetized rail. Spectrophotometric analysis may be made at the captured lines and zones for qualitative and quantitative analysis of unidentifiable analyte. A multimode photometer consisting of an optical canopy and base that defines an optical chamber may be utilized for conducting spectral or multi-spectral analysis.

    摘要翻译： 新的磁测定方法和系统，以及用于进行分光光度分析的系统。 根据一个优选的实施方案，磁性测定方法和系统包含被设计成与具有活化的磁性颗粒的测试溶液接触的色谱介质，例如分析测试条。 另外提供了由磁体或电磁体产生的磁场，如果选择性地施加到色谱介质上，使得带电粒子在磁体的位置所指定的色谱介质中的所有位置上基本上结合在一起，从而形成 捕获的线或区域。 可以选择性地调整施加到介质的磁力的程度以改变捕获线或区域的宽度或表面积。 此外，在优选实施例中，捕获线可以在测试条沿着固定磁化轨道运动的同时形成。 可以在捕获的线和区域进行分光光度分析，以对不可识别的分析物进行定性和定量分析。 由光学罩和限定光学室的基座组成的多模光度计可用于进行光谱或多光谱分析。

    Enzymatic electrode and electrode module and method of use
    4.
    发明授权
    Enzymatic electrode and electrode module and method of use 失效
    酶电极和电极模块及使用方法

    公开(公告)号：US4891104A

    公开(公告)日：1990-01-02

    申请号：US42266

    申请日：1987-04-24

    申请人： Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

    发明人： Max D. Liston ,  Paul K. Hsei ,  Christopher C. Feistel

    IPC分类号： G01N27/28 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/416 ,  G01N33/487

    CPC分类号： C12Q1/001

    摘要： An improved enzymatic electrode and electrode module specifically adapted for use in a medical analyzer device is disclosed which permits rapid analysis of substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The enzymatic electrode is in fluid communication with an axially reciprocating probe which selectively transports either a quantity of a buffer aqueous solution or a calibrant aqueous solution presented at a wash cell or a body fluid specimen disposed within a sample cup to an active enzyme bearing membrane positioned adjacent the enzymatic electrode. The membrane comprises a composite membrane structure having a protective membrane layer adapted to prevent the passage of blood cells and other particulate or cellular substances therethrough as well as adjust the diffusion rate of the substance of interest desired to be measured into the membrane, an active enzyme layer adapted to convert the desired substance of interest to be measured into a detectable substance and a limiting membrane formed to prevent the passage of interfering low molecular weight substance therethrough. The membrane/reagent chemistry kinetics of the enzymatic electrode are specifically defined to enable a novel pseudo-rate/created peak measurement technique to be utilized which reduces measurement inaccuracies as well as signal data processing requirements. The membrane/electrode support structure and membrane/electrode solution flow path are specifically formed to permit rapid replacement of the composite membrane and aqueous solutions by non-professional personnel.

    摘要翻译： 公开了一种特别适用于医疗分析装置的改进的酶电极和电极模块，其允许快速分析未稀释的体液如全血，血清和/或血浆中所含的感兴趣物质。 酶电极与轴向往复式探针流体连通，该探针选择性地将一定量的缓冲水溶液或呈现在洗涤池的校准液水溶液或设置在样品杯内的体液样品输送到位于 邻近酶电极。 膜包括具有保护膜层的复合膜结构，其适于防止血细胞和其它颗粒或细胞物质通过其中，并且调节所需要测量的物质的扩散速率到膜中，活性酶 层，其适于将要测量的所需物质转化为可检测物质和形成以防止干扰低分子量物质通过的限制膜。 酶电极的膜/试剂化学动力学具体定义为使得能够利用新的伪速率/创建的峰值测量技术，其减少测量不准确度以及信号数据处理要求。 膜/电极支撑结构和膜/电极溶液流动路径是特别形成的，以允许非专业人员快速更换复合膜和水溶液。