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公开(公告)号：US4891104A
公开(公告)日：1990-01-02
申请号：US42266
申请日：1987-04-24
IPC分类号： G01N27/28 , C12Q1/00 , G01N27/327 , G01N27/416 , G01N33/487
CPC分类号： C12Q1/001
摘要： An improved enzymatic electrode and electrode module specifically adapted for use in a medical analyzer device is disclosed which permits rapid analysis of substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The enzymatic electrode is in fluid communication with an axially reciprocating probe which selectively transports either a quantity of a buffer aqueous solution or a calibrant aqueous solution presented at a wash cell or a body fluid specimen disposed within a sample cup to an active enzyme bearing membrane positioned adjacent the enzymatic electrode. The membrane comprises a composite membrane structure having a protective membrane layer adapted to prevent the passage of blood cells and other particulate or cellular substances therethrough as well as adjust the diffusion rate of the substance of interest desired to be measured into the membrane, an active enzyme layer adapted to convert the desired substance of interest to be measured into a detectable substance and a limiting membrane formed to prevent the passage of interfering low molecular weight substance therethrough. The membrane/reagent chemistry kinetics of the enzymatic electrode are specifically defined to enable a novel pseudo-rate/created peak measurement technique to be utilized which reduces measurement inaccuracies as well as signal data processing requirements. The membrane/electrode support structure and membrane/electrode solution flow path are specifically formed to permit rapid replacement of the composite membrane and aqueous solutions by non-professional personnel.
摘要翻译： 公开了一种特别适用于医疗分析装置的改进的酶电极和电极模块，其允许快速分析未稀释的体液如全血，血清和/或血浆中所含的感兴趣物质。 酶电极与轴向往复式探针流体连通，该探针选择性地将一定量的缓冲水溶液或呈现在洗涤池的校准液水溶液或设置在样品杯内的体液样品输送到位于 邻近酶电极。 膜包括具有保护膜层的复合膜结构，其适于防止血细胞和其它颗粒或细胞物质通过其中，并且调节所需要测量的物质的扩散速率到膜中，活性酶 层，其适于将要测量的所需物质转化为可检测物质和形成以防止干扰低分子量物质通过的限制膜。 酶电极的膜/试剂化学动力学具体定义为使得能够利用新的伪速率/创建的峰值测量技术，其减少测量不准确度以及信号数据处理要求。 膜/电极支撑结构和膜/电极溶液流动路径是特别形成的，以允许非专业人员快速更换复合膜和水溶液。
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2.发明授权Ion selective/enzymatic electrode medical analyzer device and method of use 失效离子选择性/酶电极医用分析仪器及其使用方法
公开(公告)号：US4935106A
公开(公告)日：1990-06-19
申请号：US798791
申请日：1985-11-15
IPC分类号： G01N27/26 , G01N27/28 , G01N33/487
CPC分类号： G01N27/3271
摘要： A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.
摘要翻译： 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。
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公开(公告)号：US4595562A
公开(公告)日：1986-06-17
申请号：US551437
申请日：1983-11-14
申请人： Max D. Liston , Paul K. Hsei
发明人： Max D. Liston , Paul K. Hsei
CPC分类号： G01N35/04 , G01N2035/00752 , G01N2035/00861 , G01N2035/0465 , G01N35/025
摘要： The present invention relates to an assembly and method for introducing and transporting sample containers in a chemical analyzer, and in particular, to an assembly for organizing randomly loaded sample containers in a positively-identifiable fashion. The assembly additionally includes a means for sequencing the organization of sample containers and a novel means for dispensing measured amounts of sample therefrom.
摘要翻译： 本发明涉及一种用于在化学分析仪中引入和运送样品容器的装置和方法，特别涉及用于以可识别的方式组织随机装载的样品容器的组件。 该组件还包括用于对样品容器的组织进行排序的装置和用于从其中分配测量量的样品的新型装置。
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公开(公告)号：US4483616A
公开(公告)日：1984-11-20
申请号：US400192
申请日：1982-07-20
申请人： Max D. Liston , Paul K. Hsei
发明人： Max D. Liston , Paul K. Hsei
CPC分类号： B01L3/5082 , B01L3/508 , B01L2200/023 , B01L2300/0854
摘要： A container for holding a small quantity of liquid. The container comprises an elongated housing having a fluid receptacle disposed in the upper end thereof. The dimensions of the receptacle are substantially less than the overall dimensions of the housing, thereby facilitating the handling of the container and inhibiting evaporation of the liquid therein.
摘要翻译： 用于容纳少量液体的容器。 容器包括细长壳体，其具有设置在其上端中的流体容器。 容器的尺寸基本上小于外壳的整体尺寸，从而便于处理容器并阻止其中的液体的蒸发。
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5.发明授权Oxygen/carbon dioxide sensor and controller for a refrigerated controlled atmosphere shipping container 失效氧/二氧化碳传感器和控制器，用于冷藏受控气氛运输集装箱
公开(公告)号：US5801317A
公开(公告)日：1998-09-01
申请号：US840331
申请日：1997-04-28
申请人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
发明人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
CPC分类号： G05D11/132 , A23L3/3418 , F25D17/042 , G05D21/02
摘要： A controller for use in a system employing selective permeable membrane technology to maintain a controlled atmosphere within a refrigerated container. The controller is electrically interfaced to an oxygen and carbon dioxide sensing device which is disposed within the container and capable of withstanding severe environmental conditions to measure the levels of oxygen and carbon dioxide within the container. The controller maintains preset levels of oxygen and carbon dioxide within the container and is adapted to calibrate the carbon dioxide and oxygen sensing devices as well as check for proper operation of the sensing devices and default to safety conditions when a failure is detected. The controller is further adapted to control the atmosphere maintenance system in a manner adapted not to increase the peak power requirements of the system.
摘要翻译： 一种用于使用选择性渗透膜技术的系统中的控制器，以将受控气氛保持在冷藏容器内。 控制器电连接到氧气和二氧化碳感测装置，氧气和二氧化碳感测装置设置在容器内并且能够承受严格的环境条件以测量容器内氧气和二氧化碳的含量。 控制器在容器内保持预设的氧气和二氧化碳浓度，适用于校准二氧化碳和氧气感测装置，并检查感测装置的正常运行情况，并在检测到故障时默认为安全条件。 控制器还适用于以不增加系统的峰值功率要求的方式来控制大气维护系统。
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公开(公告)号：US5357113A
公开(公告)日：1994-10-18
申请号：US977662
申请日：1992-11-18
IPC分类号： G01N21/37
CPC分类号： G01N21/37
摘要： A pneumatic detector, non-dispersive infrared analyzer employing detector cell chambers in optical series. The invention having an auxiliary chamber communicating with the front chamber to increase the rear chamber's signal so as to balance the signals from the front and rear chambers. The use of xenon as a diluent gas in the detector chambers in combination with a mass flow detector to improve the sensitivity. The use of an improved synchronous detection method employing a voltage-to-frequency circuit to convert the detector signal to a synchronous high resolution digital signal. The use of an improved source electrically pulsed having low thermal mass and a large radiating area.
摘要翻译： 一种采用光学系列的探测器室的气动探测器，非分散红外分析仪。 本发明具有与前室连通的辅助室，以增加后室的信号，以平衡来自前室和后室的信号。 在检测器室中使用氙气作为稀释气体，与质量流量检测器结合使用，以提高灵敏度。 使用采用电压 - 频率电路的改进的同步检测方法将检测器信号转换成同步高分辨率数字信号。 使用具有低热质量和大的辐射面积的电脉冲改进源。
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公开(公告)号：USD277788S
公开(公告)日：1985-02-26
申请号：US400103
申请日：1982-07-20
申请人： Max D. Liston , Paul K. Hsei
设计人： Max D. Liston , Paul K. Hsei
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8.发明授权Oxygen/carbon dioxide sensor and controller for a refrigerated controlled atmosphere shipping container 有权氧/二氧化碳传感器和控制器，用于冷藏受控气氛运输集装箱
公开(公告)号：US6092430A
公开(公告)日：2000-07-25
申请号：US309206
申请日：1999-05-10
申请人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
发明人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
CPC分类号： G05D11/132 , A23L3/3418 , F25D17/042 , G05D21/02
摘要： A controller for use in a system employing selective permeable membrane technology to maintain a controlled atmosphere within a refrigerated container. The controller is electrically interfaced to an oxygen and carbon dioxide sensing device which is disposed within the container and capable of withstanding severe enviromental conditions to measure the levels of oxygen and carbon dioxide within the container. The controller maintains present levels of oxygen and carbon dioxide within the container and is adapted to calibrate the carbon dioxide and oxygen sensing devices as well as check for proper operation of the sensing devices and default to safety conditions when a failure is detected. The controller is further adapted to control the atmosphere maintenance system in a manner adapted not to increase the peak power requirements of the system.
摘要翻译： 一种用于使用选择性渗透膜技术的系统中的控制器，以将受控气氛保持在冷藏容器内。 控制器电连接到氧气和二氧化碳感测装置，其设置在容器内并且能够承受严格的环境条件以测量容器内的氧气和二氧化碳的水平。 控制器保持容器内的氧气和二氧化碳的现有水平，并且适于校准二氧化碳和氧气感测装置以及检查感测装置的正常操作，并且在检测到故障时默认为安全条件。 控制器还适用于以不增加系统的峰值功率要求的方式来控制大气维护系统。
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公开(公告)号：US4946651A
公开(公告)日：1990-08-07
申请号：US194935
申请日：1988-05-17
IPC分类号： G01N33/487
CPC分类号： G01N27/3271 , Y10T436/11
摘要： A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.
摘要翻译： 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。
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10.发明授权Oxygen/carbon dioxide sensor and controller for a refrigerated controlled atmosphere shipping container 失效氧/二氧化碳传感器和控制器，用于冷藏受控气氛运输集装箱
公开(公告)号：US5623105A
公开(公告)日：1997-04-22
申请号：US374876
申请日：1995-01-19
申请人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
发明人： Max D. Liston , Todd I. Harrison , Paul K. Hsei
CPC分类号： G05D11/132 , A23L3/3418 , F25D17/042 , G05D21/02
摘要： A controller for use in a system employing selective permeable membrane technology to maintain a controlled atmosphere within a refrigerated container. The controller is electrically interfaced to an oxygen and carbon dioxide sensing device which is disposed within the container and capable of withstanding severe environmental conditions to measure the levels of oxygen and carbon dioxide within the container. The controller maintains preset levels of oxygen and carbon dioxide within the container and is adapted to calibrate the carbon dioxide and oxygen sensing devices as well as check for proper operation of the sensing devices and default to safety conditions when a failure is detected. The controller is further adapted to control the atmosphere maintenance system in a manner adapted not to increase the peak power requirements of the system.
摘要翻译： 一种用于使用选择性渗透膜技术的系统中的控制器，以将受控气氛保持在冷藏容器内。 控制器电连接到氧气和二氧化碳感测装置，氧气和二氧化碳感测装置设置在容器内并且能够承受严格的环境条件以测量容器内氧气和二氧化碳的含量。 控制器在容器内保持预设的氧气和二氧化碳浓度，适用于校准二氧化碳和氧气感测装置，并检查感测装置的正常运行情况，并在检测到故障时默认为安全条件。 控制器还适用于以不增加系统的峰值功率要求的方式来控制大气维护系统。
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