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公开(公告)号：US4994238A
公开(公告)日：1991-02-19
申请号：US205230
申请日：1988-06-09
CPC分类号： G01N33/525 , C12Q1/54
摘要： The multilayer test devices of this invention comprise, in order, (a) an absorbent layer; (b) a waterproof barrier layer; and (c) a quickly absorbent reagent layer having a determinate volume. The absorbent and barrier layers each include an aperture functionally aligned for application of a test sample through the absorbent and barrier layers and onto the surface of the reagent layer. The reagent layer contains one or more reagents which produce a detectable species in the presence of an analyte. The reagent layer preferably comprises an asymmetrical filter, which localizes cellular components of the test sample at or near the surface of the filter, while facilitating saturation of the filter by non-cellular sample components. Preferred embodiments of the test devices include devices for testing glucose, alcohol, cholesterol, or other analytes in whole blood.
摘要翻译： 本发明的多层测试装置按顺序包括（a）吸收层; （b）防水阻隔层; 和（c）具有确定体积的快速吸收试剂层。 吸收层和阻挡层各自包括功能上对齐的用于通过吸收剂和阻挡层施加测试样品并且到试剂层的表面上的孔。 试剂层含有一种或多种在分析物存在下产生可检测物质的试剂。 试剂层优选地包括不对称过滤器，其将过滤器表面处或附近的测试样品的细胞组分定位，同时促进过滤器由非细胞样品组分的饱和。 测试装置的优选实施例包括用于测试全血中葡萄糖，酒精，胆固醇或其他分析物的装置。
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2.发明授权Ion selective/enzymatic electrode medical analyzer device and method of use 失效离子选择性/酶电极医用分析仪器及其使用方法
公开(公告)号：US4935106A
公开(公告)日：1990-06-19
申请号：US798791
申请日：1985-11-15
IPC分类号： G01N27/26 , G01N27/28 , G01N33/487
CPC分类号： G01N27/3271
摘要： A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.
摘要翻译： 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。
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3.发明授权
公开(公告)号：US5515170A
公开(公告)日：1996-05-07
申请号：US302282
申请日：1994-09-08
IPC分类号： G01N33/483 , G01N21/27 , G01N21/78 , G01N21/86 , G01N33/52 , G01N33/66 , G01J3/52 , G01N21/00 , G01N21/47
CPC分类号： G01N21/8483
摘要： An apparatus comprising a passageway for accepting a strip for determining the presence or quantity of an analyte is provided. The passageway has a serpentine shape to maintain the strip against an optical aperture in the passageway wall, insuring that a constant optical reading is obtained.
摘要翻译： 提供一种包括用于接收用于确定分析物的存在或数量的条带的通道的装置。 通道具有蛇形形状，以将条保持抵靠通道壁中的光学孔，确保获得恒定的光学读数。
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公开(公告)号：US4946651A
公开(公告)日：1990-08-07
申请号：US194935
申请日：1988-05-17
IPC分类号： G01N33/487
CPC分类号： G01N27/3271 , Y10T436/11
摘要： A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. The ion selective electrode and/or the enzymatic electrode are disposed upon a probe which automatically axially reciprocates downwardly in a simple manipulative motion between an open-ended reference wash cell and a sample cup bearing the body fluid specimen to be analyzed. The wash cell includes an inlet port and one or more outlet ports through which is circulated an aqueous solution bearing a known concentration of the substance to be measured to provide a reference calibration medium as well as a probe washing medium. The probe is lowered directly into the sample cup to physically contact the specimen to be measured and, after analysis, is lifted upwardly into the wash cell wherein any attendant portion of the specimen remaining on the probe is stripped off by suction and the aqueous solution flow through the wash cell is initiated to thoroughly wash the probe and establish a new calibration medium for subsequent specimen analysis. The wash cell/probe assembly is specifically designed to prevent any leakage or drooling of the aqueous solution from the wash cell into the sample cup throughout manipulation of the probe. Operation of each of the modules of the analyzer is facilitated through common processing and control electronics and test measurements are accomplished initially on a dual point calibration procedure and subsequently on a single point calibration procedure.
摘要翻译： 公开了一种模块化多通道自动医学分析仪装置，其特征在于使用离子选择性电极和/或酶电极/洗涤细胞系统，其允许快速分析未稀释体液中所含的各种感兴趣物质，例如全血，血清和 /或等离子体。 离子选择电极和/或酶电极设置在探针上，该探针在开放式参考洗涤池和承载待分析体液样品的样品杯之间的简单操作运动中向下自动轴向往复运动。 洗涤池包括入口端口和一个或多个出口端口，循环具有已知浓度待测量物质的水溶液以提供参考校准介质以及探针洗涤介质。 将探针直接放入样品杯中以物理接触要测量的样品，并且在分析之后，将其向上提升到洗涤池中，其中留在探针上的样品的任何附加部分通过抽吸被剥离，并且水溶液流 通过洗涤池开始彻底清洗探针并建立新的校准介质，用于随后的样品分析。 洗涤池/探针组件被专门设计成防止在操纵探针时水溶液从洗涤池中渗入或流出到样品杯中。 通过共同的处理和控制电子装置便于分析器的每个模块的操作，并且测试测量最初在双点校准程序上完成，随后在单点校准程序上完成。
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公开(公告)号：US4279509A
公开(公告)日：1981-07-21
申请号：US100587
申请日：1979-12-05
申请人： George M. Daffern
发明人： George M. Daffern
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A flow cell for optical analysis of a fluid sample has a cell chamber whose volume is not limited by considerations of fluid residue carryover. A piston movable within the viewing region and having a conduit through its face is used to collapse the volume of the viewing region to substantially zero while maintaining a flow path between inlet and outlet conduits so that residue can be removed from the flow cell and its conduits with a minimum of cleaning fluid.
摘要翻译： 用于流体样品的光学分析的流动池具有容积不受流体残留物残留的考虑的细胞室。 在观察区域内可移动并具有穿过其表面的导管的活塞用于将观察区域的体积折叠到基本上为零，同时保持入口和出口管道之间的流动路径，使得残留物可以从流动池及其导管 用最少的清洁液。
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