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    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME
    2.
    发明申请
    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME 有权
    润滑剂及其制备和使用方法

    公开(公告)号：US20120295326A1

    公开(公告)日：2012-11-22

    申请号：US13562881

    申请日：2012-07-31

    Applicant: Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    Inventor： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC: C12N9/02 ,  C12N1/21 ,  C12N1/19 ,  C12N15/63 ,  C12N5/10

    CPC classification number: C12Q1/66

    Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    Luciferases and methods for making and using the same
    3.
    发明授权
    Luciferases and methods for making and using the same 有权
    萤光素酶及其制备和使用方法

    公开(公告)号：US08173791B2

    公开(公告)日：2012-05-08

    申请号：US13070665

    申请日：2011-03-24

    Applicant: Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    Inventor： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC: C07H21/04 ,  C12N15/00 ,  C12N9/02

    CPC classification number: C12Q1/66

    Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    BIOTIN-LIGASE SYSTEM FOR SECRETION OF BIOTINYLATED PROTEIN
    5.
    发明申请
    BIOTIN-LIGASE SYSTEM FOR SECRETION OF BIOTINYLATED PROTEIN 有权
    用于生物素蛋白分泌的生物素系统

    公开(公告)号：US20090275081A1

    公开(公告)日：2009-11-05

    申请号：US12363678

    申请日：2009-01-30

    Applicant: Bhaswati Barat ,  Anna M. Wu

    Inventor： Bhaswati Barat ,  Anna M. Wu

    IPC: C12P21/00 ,  C12N5/00

    CPC classification number: C12P21/02

    Abstract: The present invention provides methods of metabolically biotinylating recombinant proteins. Cell lines and specific protein and nucleic acid constructs for use in the methods of the present invention are also provided herein.

    Abstract translation: 本发明提供代谢生物素化重组蛋白的方法。 本文还提供了用于本发明方法的细胞系和特异性蛋白质和核酸构建体。

    Antibody construct
    6.
    发明授权
    Antibody construct 失效
    抗体构建体

    公开(公告)号：US5837821A

    公开(公告)日：1998-11-17

    申请号：US256156

    申请日：1994-06-24

    Applicant: Anna M. Wu

    Inventor： Anna M. Wu

    IPC: C07K16/00 ,  C07K16/30 ,  C07K16/46 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  C12N15/10

    CPC classification number: C07K16/468 ,  C07K16/00 ,  C07K16/3007 ,  Y10S530/866 ,  Y10S530/867

    Abstract: An antigen binding protein construct or "minibody" which includes the VL and VH domains of a native antibody fused to the hinge region and CH3 domain of the immunoglobulin molecule is described. Minibodies are small versions of whole antibodies which encode in a single chain the essential elements of a whole antibody. Minibodies are expressed by host cells transformed with minibody genes.

    Abstract translation: PCT No.PCT / US92 / 09347 Sec。 371日期：1994年6月24日 102（e）日期1994年6月24日PCT提交1992年11月4日PCT公布。 第WO94 / 09817号公报 日期1994年5月11日描述了包含与免疫球蛋白分子的铰链区和CH3结构域融合的天然抗体的VL和VH结构域的抗原结合蛋白构建体或“微型体”。 小抗体是在单链中编码整个抗体的基本元件的全部抗体的小版本。 小细胞被用小体细胞基因转化的宿主细胞表达。

    Luciferases and methods for making and using the same
    8.
    发明授权
    Luciferases and methods for making and using the same 有权
    萤光素酶及其制备和使用方法

    公开(公告)号：US08378086B2

    公开(公告)日：2013-02-19

    申请号：US13562881

    申请日：2012-07-31

    Applicant: Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    Inventor： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC: C07H21/04 ,  C12N5/00

    CPC classification number: C12Q1/66

    Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    Luciferases and methods for making and using the same
    9.
    发明授权
    Luciferases and methods for making and using the same 有权

    公开(公告)号：US08258277B2

    公开(公告)日：2012-09-04

    申请号：US13426790

    申请日：2012-03-22

    Applicant: Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    Inventor： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC: C07H21/04 ,  C12N5/00

    CPC classification number: C12Q1/66

    Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

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