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公开(公告)号：US20120295326A1
公开(公告)日：2012-11-22
申请号：US13562881
申请日：2012-07-31
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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公开(公告)号：US08173791B2
公开(公告)日：2012-05-08
申请号：US13070665
申请日：2011-03-24
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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公开(公告)号：US08378086B2
公开(公告)日：2013-02-19
申请号：US13562881
申请日：2012-07-31
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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公开(公告)号：US08258277B2
公开(公告)日：2012-09-04
申请号：US13426790
申请日：2012-03-22
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
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公开(公告)号：US20090136998A1
公开(公告)日：2009-05-28
申请号：US11995586
申请日：2006-09-06
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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Patent Agency Ranking
公开(公告)号：US20120178141A1
公开(公告)日：2012-07-12
申请号：US13426790
申请日：2012-03-22
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
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公开(公告)号：US20110229955A1
公开(公告)日：2011-09-22
申请号：US13070665
申请日：2011-03-24
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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公开(公告)号：US07939649B2
公开(公告)日：2011-05-10
申请号：US11995586
申请日：2006-09-06
Applicant: Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
Inventor： Sanjiv S. Gambhir , Andreas M. Loening , Anna M. Wu
CPC classification number: C12Q1/66
Abstract: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
Abstract translation: 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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公开(公告)号：US08318906B2
公开(公告)日：2012-11-27
申请号：US12682032
申请日：2008-10-08
Applicant: Jonathan Braun , Lynn K. Gordon , Kaori Shimizaki , Madhuri Wadegra-Dhawan , Kathy A. Kelly , Anna M. Wu
Inventor： Jonathan Braun , Lynn K. Gordon , Kaori Shimizaki , Madhuri Wadegra-Dhawan , Kathy A. Kelly , Anna M. Wu
IPC: C07K16/00 , C12P21/08 , A61K39/395 , G01N33/566
CPC classification number: C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
Abstract translation: 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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公开(公告)号：US08088908B2
公开(公告)日：2012-01-03
申请号：US11432304
申请日：2006-05-10
Applicant: Mark A. Sherman , Anna M. Wu , Robert E. Reiter
Inventor： Mark A. Sherman , Anna M. Wu , Robert E. Reiter
IPC: C07H21/04
CPC classification number: C07K16/3069 , A61K2039/505 , C07K2317/24 , C07K2317/565
Abstract: Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA.
Abstract translation: 前列腺干细胞抗原（PSCA）在大多数前列腺癌患者中表达，使其成为癌症免疫治疗的理想靶标。 鼠单克隆抗体1G8以纳摩尔亲和力结合PSCA，但其作为治疗剂的功效受到HAMA反应的产生的限制。 本发明公开了大部分小鼠来源的表位已被除去的人源化1G8抗体。 这些人源化抗体以高亲和力和特异性结合PSCA，并已显示可以减少人膀胱肿瘤的裸鼠模型。 这些特征使得本发明的人源化抗体用于治疗和检测表达PSCA的肿瘤的吸引剂。
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