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    RNA Interferases and Methods of Use Thereof
    2.
    发明申请
    RNA Interferases and Methods of Use Thereof 审中-公开
    RNA干扰物及其使用方法

    公开(公告)号：US20140234258A1

    公开(公告)日：2014-08-21

    申请号：US14226990

    申请日：2014-03-27

    申请人： University of Medicine and Dentistry of New Jersey

    发明人： Masayori Inouye ,  Junjie Zhang ,  Yong Long Zhang

    IPC分类号： C12N9/22

    CPC分类号： C12N9/22 ,  A61K38/465 ,  C12N15/70 ,  C12P19/34 ,  C12Q1/42 ,  C12Q1/44 ,  G01N2333/922 ,  G01N2800/26

    摘要： The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also encompasses screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. Also provided is a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers, and instruction materials.

    摘要翻译： 本发明涉及在本文中称为表达内切核糖核酸酶活性的mRNA干扰酶的新型家族的发现。 因此，本发明人的新发现提出了可以使用mRNA干扰酶核酸和氨基酸序列及其组合物的新用途。 本发明还包括鉴定能够调节mRNA干扰酶活性的化合物/试剂的筛选方法以及使用这些化合物/试剂的方法。 还提供了包含mRNA干扰酶核酸和/或氨基酸序列，mRNA干扰酶活性相容缓冲液和说明材料的试剂盒。

    Compositions and Methods for the Treatment and Prevention of Infections Caused by Staphylococcus aureus Bacteria
    4.
    发明申请
    Compositions and Methods for the Treatment and Prevention of Infections Caused by Staphylococcus aureus Bacteria 失效
    用于治疗和预防由金黄色葡萄球菌引起的感染的组合物和方法

    公开(公告)号：US20140170131A1

    公开(公告)日：2014-06-19

    申请号：US13609714

    申请日：2012-09-11

    申请人： Jeffrey B. Kaplan

    发明人： Jeffrey B. Kaplan

    IPC分类号： A01N63/00 ,  A01N33/02

    CPC分类号： A01N63/00 ,  A01N33/02 ,  A61K31/14 ,  A61K38/465 ,  A61K45/06 ,  C12Y301/21001 ,  A61K2300/00

    摘要： The present invention relates to antimicrobial deoxyribonuclease-based compositions that inhibit growth and proliferation of Staphylococcus aureus bacteria. The present invention also relates to methods of administering the compositions in the treatment and prevention of S. aureus infections. The present invention also relates to methods of administering the compositions in the eradication of S. aureus nasal carriage, in order to prevent the transmission of S. aureus bacteria

    摘要翻译： 本发明涉及抑制金黄色葡萄球菌生长和增殖的抗微生物脱氧核糖核酸酶基组合物。 本发明还涉及给组合物治疗和预防金黄色葡萄球菌感染的方法。 本发明还涉及将组合物施用于根除金黄色葡萄球菌鼻塞的方法，以防止金黄色葡萄球菌的传播

    CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE
    5.
    发明申请
    CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE 有权
    CITROBACTER FREUNDII抗菌剂及其使用

    公开(公告)号：US20140073560A1

    公开(公告)日：2014-03-13

    申请号：US14079458

    申请日：2013-11-13

    申请人： Robert Michael Queen Shanks ,  Daniel E. Kadouri

    发明人： Robert Michael Queen Shanks ,  Daniel E. Kadouri

    IPC分类号： C07K14/24

    CPC分类号： C07K14/24 ,  A01N37/46 ,  A61K38/00

    摘要： Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter freundii colicin A polypeptide, wherein the polypeptide has an antibacterial activity against the planktonic bacteria or the biofilm. Methods are also provided herein for treating a subject that has a bacterial infection, for example caused by a biofilm. The methods can be used to treat a biofilm on a living or non-living surface. Also provided herein are Citrobacter freundii colicin A polypeptides that have an antibacterial activity against planktonic bacteria or surface attached bacteria, and nucleic acid sequences encoding the polypeptides. Medical devices comprising a surface having an antimicrobial effective amount of a Citrobacter freundii colicin A polypeptide, or a nucleic acid molecule encoding the polypeptide, are also disclosed.

    摘要翻译： 本文提供了用于处理浮游细菌或生物膜的方法。 所述方法包括使浮游细菌或生物膜与有效量的分离的弗氏柠檬酸杆菌大肠菌素A多肽接触，其中所述多肽对浮游细菌或生物膜具有抗菌活性。 本文还提供了治疗患有细菌感染（例如由生物膜引起）的受试者的方法。 该方法可用于处理活体或非生物表面上的生物膜。 本文还提供了对浮游细菌或表面附着的细菌具有抗菌活性的弗氏柠檬酸杆菌大肠杆菌素A多肽和编码多肽的核酸序列。 还公开了包含具有抗微生物有效量的弗氏柠檬酸杆菌大肠菌素B多肽的表面或编码该多肽的核酸分子的医疗装置。

    IMPLANTABLE DEVICES COATED WITH INSULIN-MIMETIC AGENT COMPOSITES AND METHODS THEREOF
    6.
    发明申请
    IMPLANTABLE DEVICES COATED WITH INSULIN-MIMETIC AGENT COMPOSITES AND METHODS THEREOF 有权
    用胰岛素 - 药物复合材料包覆的可植入装置及其方法

    公开(公告)号：US20140044768A1

    公开(公告)日：2014-02-13

    申请号：US13992927

    申请日：2011-12-09

    申请人： Sheldon S. Lin ,  David N. Paglia ,  Eric Breitbart ,  Joseph Benevenia

    发明人： Sheldon S. Lin ,  David N. Paglia ,  Eric Breitbart ,  Joseph Benevenia

    IPC分类号： A61L31/08

    CPC分类号： A61L31/08 ,  A61K9/0024 ,  A61K9/0092 ,  A61K31/28 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/40 ,  A61L2420/04 ,  A61L2430/02

    摘要： The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.

    摘要翻译： 本发明公开了基于钒的胰岛素模拟剂复合涂层，将这些涂层应用于可植入装置，以及使用可植入装置来加速骨愈合。 本发明还包括制造涂覆有基于钒的胰岛素模拟剂复合涂层的可植入装置和如此制造的可植入装置的方法。 可植入装置具有广泛的应用，包括但不限于治疗骨折，骨创伤，关节固定术和其他骨缺损状况，以及在军事和体育活动中引起的骨损伤。