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公开(公告)号：US11980662B2
公开(公告)日：2024-05-14
申请号：US17675297
申请日：2022-02-18
申请人： FluGen, Inc.
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/575 , C12N2760/16134 , C12N2760/16143 , C12N2760/16152
摘要： Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
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公开(公告)号：US20180245052A1
公开(公告)日：2018-08-30
申请号：US15566202
申请日：2016-11-03
IPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , A61K35/76 , A61K39/145 , A61P31/16
CPC分类号： C12N7/00 , A61K35/76 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/876 , A61P31/16 , C07K14/005 , C12N15/86 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16171
摘要： The present invention relates to the field of medicine and virology. An attenuated influenza A virus, an influenza virus vector based thereon, and a pharmaceutical composition comprising thereof are provided, which can be used for the prevention and/or treatment of an infectious disease. In addition, the present invention relates to an attenuated influenza A virus, an influenza virus vector based thereon, and a pharmaceutical composition comprising thereof, which can be used for the treatment of oncological diseases.
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公开(公告)号：US20180043007A1
公开(公告)日：2018-02-15
申请号：US15681613
申请日：2017-08-21
申请人： FluGen, Inc.
IPC分类号： A61K39/145 , C12N7/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/575 , C12N7/00 , C12N2760/16134 , C12N2760/16143 , C12N2760/16152
摘要： Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
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公开(公告)号：US20170368165A1
公开(公告)日：2017-12-28
申请号：US15538133
申请日：2015-12-30
发明人： SANG-MOO KANG , YU-NA LEE , MIN-CHUL KIM
IPC分类号： A61K39/145 , C07K14/005 , A61K39/295 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/295 , A61K2039/55505 , C07K14/005 , C07K2319/00 , C12N2760/16134 , C12N2760/16143 , C12N2760/18534
摘要： Disclosed are recombinant chimeric influenza virus vaccines and live attenuated influenza virus (LAIV) vaccines expressing foreign (RSV) neutralizing epitopes or conserved M2e epitopes that are capable of providing broader cross-protection against influenza virus and/or protecting against respiratory syncytial virus (RSV) without vaccine-enhanced RSV disease (ERD).
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公开(公告)号：US20170321192A1
公开(公告)日：2017-11-09
申请号：US15480800
申请日：2017-04-06
发明人： Benjamin R. tenOever
CPC分类号： C12N7/00 , C12N15/111 , C12N15/86 , C12N2330/51 , C12N2760/16143 , C12N2770/36143
摘要： Described herein are modified RNA virus gene segments and nucleic acids encoding modified RNA virus gene segments. Also described herein are recombinant RNA viruses comprising modified RNA virus gene segments and the use of such recombinant RNA viruses for the prevention and treatment of disease.
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公开(公告)号：US09694067B2
公开(公告)日：2017-07-04
申请号：US15107074
申请日：2014-12-12
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16171
摘要： The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.
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公开(公告)号：US20170106077A1
公开(公告)日：2017-04-20
申请号：US15125763
申请日：2015-03-13
申请人： FLUGEN, INC.
IPC分类号： A61K39/145 , C12N7/00 , A61K39/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/575 , C12N7/00 , C12N2760/16134 , C12N2760/16143 , C12N2760/16152
摘要： Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. The mutant viruses disclosed herein including a mutant M2 sequence are also useful to deliver antigens to a subject, e.g., to induce an immune response to the antigen. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
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公开(公告)号：US20170067029A1
公开(公告)日：2017-03-09
申请号：US15203581
申请日：2016-07-06
发明人： Yoshihiro Kawaoka , Gabriele Neumann , Jihui Ping
IPC分类号： C12N7/00 , C07K14/005 , C12N15/86
CPC分类号： C12N7/00 , A61K39/145 , C07K14/005 , C12N15/86 , C12N2760/16111 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16151
摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
摘要翻译： 本发明提供了可用于制备高滴度流感病毒的组合物，例如在不存在辅助病毒的情况下，其包括来自流感病毒疫苗株或分离物的内部基因，例如在人类中是安全的，例如， 不会导致显着的疾病，这会导致培养细胞增殖，如MDCK细胞，或卵中。
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公开(公告)号：US20160368949A1
公开(公告)日：2016-12-22
申请号：US14887115
申请日：2015-10-19
申请人： The Government of the United States of America as Represented by the Secretary of the Department of
发明人： Hana Golding , Surender Khurana
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/55566 , A61K2039/575 , C07K2319/21 , C12N7/00 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16152 , G01N33/559 , G01N33/56983 , G01N2333/11
摘要： The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.
摘要翻译： 本发明包括当在细菌中表达时能够适当折叠的流感血凝素蛋白片段。
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公开(公告)号：US09238825B2
公开(公告)日：2016-01-19
申请号：US14038704
申请日：2013-09-26
申请人： MEDIMMUNE, LLC
发明人： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04 , C12N15/86 , C07K14/005 , C12N7/00 , C12N15/85
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
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