公开(公告)号：US09694067B2

公开(公告)日：2017-07-04

申请号：US15107074

申请日：2014-12-12

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Fang He ,  Hwei-Sing Jimmy Kwang ,  Prabakaran Mookkan

IPC: A61K39/145 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16171

Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.