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公开(公告)号：US12122994B2
公开(公告)日：2024-10-22
申请号：US18186257
申请日：2023-03-20
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Si Te Ngoh
CPC classification number: C12N1/14 , C12N1/145 , C12P17/06 , C12N2500/22 , C12N2500/24 , C12N2500/42 , C12R2001/645
Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42−; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.
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2.发明公开公开(公告)号：US20240344991A1
公开(公告)日：2024-10-17
申请号：US18685153
申请日：2022-08-19
Inventor： Pil Joong CHUNG , Sayuj KOYYAPPURATH , Nam-Hai CHUA , Rajani SAROJAM , Gajendra Pratap SINGH , Rajeev J. RAM
CPC classification number: G01N21/65 , G01N33/0098
Abstract: The present invention relates to the use of Raman spectroscopy for the real time detection and quantitation of innate immunity response in plants. More specifically, the present invention provides Raman spectroscopy as a tool for rapid, non-invasive, and early detection and quantitation of plant innate immune response.
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公开(公告)号：US20230243750A1
公开(公告)日：2023-08-03
申请号：US17999331
申请日：2021-05-20
Inventor： In-Cheol JANG , Benny Jian Rong SNG , Gajendra Pratap SINGH , Rajeev J. RAM
CPC classification number: G01N21/65 , G01N21/84 , G01N33/0098 , G01N2021/8466
Abstract: The present invention relates to the use of a Raman spectral signature for detection of plant metabolites, specifically carotenoids, in tissue of a plant leaf. Carotenoids are used as a biomarker for an early, real-time diagnosis of shade avoidance syndrome (SAS) in growing plants in a non-invasive or non-destructive way in order to detect the adverse effect of the SAS upon their health, and ultimately their yield. The early, real-time diagnosis of SAS provides a window period within which further adverse effects of SAS may be slowed or prevented without negatively affecting the yield of growing plants or leafy vegetables.
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公开(公告)号：US20210123066A1
公开(公告)日：2021-04-29
申请号：US16963133
申请日：2019-01-17
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： In-Cheol JANG , Jun-shi ZHENG , Mi Jung KIM
Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-indoleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS1 and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G1 in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.
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公开(公告)号：US10266837B2
公开(公告)日：2019-04-23
申请号：US15519595
申请日：2015-10-19
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： In-cheol Jang , Mi Jung Kim
Abstract: The present invention relates to the field of plant molecular biology. More particularly, the present invention relates to the isolation of nucleic acids encoding terpene synthases (TPSs), including a novel, multifunctional TPS identified herein as CoTPS2.
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Patent Agency Ranking
公开(公告)号：US20190062799A1
公开(公告)日：2019-02-28
申请号：US16079270
申请日：2017-02-23
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Rongji SUM , Muthukaruppan SWAMINATHAN , Ian CHEONG
Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
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7.发明申请公开(公告)号：US20150101373A1
公开(公告)日：2015-04-16
申请号：US14386673
申请日：2013-03-20
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Madhaiyan Munusamy , Lianghui Ji
CPC classification number: C05F11/08 , A01N63/00 , C05D9/02 , C12N1/20 , C12N9/0095 , C12N9/0097 , C12R1/01 , C12Y118/06001 , C12Y119/06001 , Y02P60/218
Abstract: The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
Abstract translation: 本发明涉及减少化肥使用和温室气体一氧化二氮排放的方法，以及通过应用含有固氮细菌的新型人工制剂，有效地定植非化学肥料的方法，提高农业中植物生长速率和种子生产力的方法， 豆类植物在地上部分和根系。 细菌接种物和方法特别适用于麻风树属，高粱属，棉子属，ae属，蓖麻属，Oryza和Manihot属的植物。
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8.发明申请METHOD FOR ISOLATING SMALL MOLECULES WITH IMPORTANT BIOLOGICAL ACTIVITY USING YEAST 审中-公开使用YEAST分离具有重要生物活性的小分子的方法公开(公告)号：US20130225515A1
公开(公告)日：2013-08-29
申请号：US13762925
申请日：2013-02-08
Applicant: Temasek Life Sciences Laboratory Limited
Inventor： Rajesh Narhari PATKAR , Naweed Isaak NAQVI
IPC: A61K31/7048
CPC classification number: A61K31/7048 , C07K1/16 , C07K14/37
Abstract: Methods of isolating biologically active molecules from an organism, for example from a fungus, are described. The methods involve isolating an active molecule which possesses a specific biological activity on, in or against wild-type yeast cells, but not on, in or against yeast cells that express a given ABC transporter from a given organism, including but not limited to Magnaporthe species such as Magnaporthe grisea. In preferred embodiments, the biological activity is antifungal activity. In most preferred embodiments, the antifungal activity is against a human pathogen, including but not limited to Candida albicans. The biologically active molecules can be formulated as pharmaceutical compositions and used to treat fungal infections in a subject, including a human subject.
Abstract translation: 描述了从生物体（例如真菌）分离生物活性分子的方法。 所述方法包括分离在野生型酵母细胞中或对抗野生型酵母细胞但不包括表达来自给定生物体的给定ABC转运蛋白的酵母细胞中或之上具有特定生物活性的活性分子，包括但不限于Magnaporthe 物种如Magnaporthe grisea。 在优选的实施方案中，生物活性是抗真菌活性。 在最优选的实施方案中，抗真菌活性是针对人类病原体，包括但不限于白色念珠菌。 生物活性分子可以配制成药物组合物并用于治疗受试者（包括人类受试者）中的真菌感染。
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9.发明授权公开(公告)号：US12228518B2
公开(公告)日：2025-02-18
申请号：US17999312
申请日：2021-05-20
Inventor： Bong Soo Park , Rajeev J. Ram , Chung Hao Huang , Gajendra Pratap Singh , Nam-Hai Chua
Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.
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公开(公告)号：US11667946B2
公开(公告)日：2023-06-06
申请号：US17077581
申请日：2020-10-22
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Rongji Sum , Muthukaruppan Swaminathan , Ian Cheong
Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
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