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公开(公告)号：US12122994B2
公开(公告)日：2024-10-22
申请号：US18186257
申请日：2023-03-20
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Si Te Ngoh
CPC classification number: C12N1/14 , C12N1/145 , C12P17/06 , C12N2500/22 , C12N2500/24 , C12N2500/42 , C12R2001/645
Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42−; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.
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2.发明申请公开(公告)号：US20150101373A1
公开(公告)日：2015-04-16
申请号：US14386673
申请日：2013-03-20
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Madhaiyan Munusamy , Lianghui Ji
CPC classification number: C05F11/08 , A01N63/00 , C05D9/02 , C12N1/20 , C12N9/0095 , C12N9/0097 , C12R1/01 , C12Y118/06001 , C12Y119/06001 , Y02P60/218
Abstract: The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
Abstract translation: 本发明涉及减少化肥使用和温室气体一氧化二氮排放的方法，以及通过应用含有固氮细菌的新型人工制剂，有效地定植非化学肥料的方法，提高农业中植物生长速率和种子生产力的方法， 豆类植物在地上部分和根系。 细菌接种物和方法特别适用于麻风树属，高粱属，棉子属，ae属，蓖麻属，Oryza和Manihot属的植物。
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公开(公告)号：US11254943B2
公开(公告)日：2022-02-22
申请号：US16070648
申请日：2017-02-02
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Yanbin Liu , Chong Mei John Koh , Sihui Amy Yap
Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
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公开(公告)号：US10570402B2
公开(公告)日：2020-02-25
申请号：US16190386
申请日：2018-11-14
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lin Cai , Longhua Sun , Lin Fu , Lianghui Ji
Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
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公开(公告)号：US10081821B2
公开(公告)日：2018-09-25
申请号：US15326077
申请日：2015-08-21
Applicant: Temasek Life Sciences Laboratory Limited
Inventor： Yanbin Liu , Chong Mei Koh , Lianghui Ji
IPC: C12N1/14 , C12N1/15 , C12N9/02 , C12P7/64 , C12N15/52 , C12N15/81 , C12N9/04 , C12N9/10 , C12N9/88 , C12N9/90 , C12N9/00
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.
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Patent Agency Ranking
公开(公告)号：US11639492B2
公开(公告)日：2023-05-02
申请号：US16712672
申请日：2019-12-12
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Si Te Ngoh
Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.
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公开(公告)号：US10308691B2
公开(公告)日：2019-06-04
申请号：US15535466
申请日：2015-12-14
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Yanbin Liu , Chong Mei Koh , Lianghui Ji
Abstract: The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.
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8.发明授权Nitrogen-fixing bacterial inoculant for improvement of crop productivity and reduction of nitrous oxide emission 有权氮固定细菌接种剂用于提高作物生产力和减少一氧化二氮排放公开(公告)号：US09580363B2
公开(公告)日：2017-02-28
申请号：US14386673
申请日：2013-03-20
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Madhaiyan Munusamy , Lianghui Ji
CPC classification number: C05F11/08 , A01N63/00 , C05D9/02 , C12N1/20 , C12N9/0095 , C12N9/0097 , C12R1/01 , C12Y118/06001 , C12Y119/06001 , Y02P60/218
Abstract: The present invention relates to methods of reducing chemical fertilizer usage and greenhouse gas nitrous oxide emission and to methods of improving plant growth rate and seed productivity in agriculture through the application of a novel artificially manufactured formula containing a nitrogen-fixing bacterium that efficiently colonizes non-legume plants in aerial parts and the root system. The bacteria inocula and methods are particularly suitable for plants in the genera Jatropha, Sorghum, Gossypium, Elaeis, Ricinus, Oryza and Manihot.
Abstract translation: 本发明涉及减少化肥使用和温室气体一氧化二氮排放的方法，以及通过应用含有固氮细菌的新型人工制剂，有效地定植非化学肥料的方法，提高农业中植物生长速率和种子生产力的方法， 豆类植物在地上部分和根系。 细菌接种物和方法特别适用于麻风树属，高粱属，棉子属，ae属，蓖麻属，Oryza和Manihot属的植物。
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公开(公告)号：US11034981B2
公开(公告)日：2021-06-15
申请号：US16484322
申请日：2018-01-29
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Lianghui Ji , Yanbin Liu , Chong Mei John Koh , Sihui Amy Yap , Si Te Ngoh
IPC: C12P7/04
Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.
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公开(公告)号：US10106802B2
公开(公告)日：2018-10-23
申请号：US14773836
申请日：2014-03-10
Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
Inventor： Hsin I. Cheng , Ni Peng , Lianghui Ji
Abstract: The present invention relates to the application of isolated promoters and synthetic constructs for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Rhodotourla, Sporobolomyces or Pseudozyma genus.
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