公开(公告)号：US12122994B2

公开(公告)日：2024-10-22

申请号：US18186257

申请日：2023-03-20

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Lianghui Ji ,  Si Te Ngoh

IPC: C12N1/14 ,  C12P17/06 ,  C12R1/645

CPC classification number: C12N1/14 ,  C12N1/145 ,  C12P17/06 ,  C12N2500/22 ,  C12N2500/24 ,  C12N2500/42 ,  C12R2001/645

Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42−; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.

公开(公告)号：US11034981B2

公开(公告)日：2021-06-15

申请号：US16484322

申请日：2018-01-29

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Lianghui Ji ,  Yanbin Liu ,  Chong Mei John Koh ,  Sihui Amy Yap ,  Si Te Ngoh

IPC: C12P7/04

Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.

公开(公告)号：US11639492B2

公开(公告)日：2023-05-02

申请号：US16712672

申请日：2019-12-12

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Lianghui Ji ,  Si Te Ngoh

IPC: C12N1/14 ,  C12P17/06 ,  C12R1/645

Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.