公开(公告)号：US09694067B2

公开(公告)日：2017-07-04

申请号：US15107074

申请日：2014-12-12

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Fang He ,  Hwei-Sing Jimmy Kwang ,  Prabakaran Mookkan

IPC: A61K39/145 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16171

Abstract: The present invention relates to a monovalent H5N1 vaccine. More specifically, the present invention relates to the development of a monovalent H5 vaccine strain using hemagglutinin (HA) engineering to elicit cross-clade protection. The present invention also relates to an epitope-chimeric H5 and to a reverse genetics (RG) influenza virus expressing the epitope-chimeric H5.

公开(公告)号：US09637537B2

公开(公告)日：2017-05-02

申请号：US14442626

申请日：2013-08-23

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Hwei-Sing Jimmy Kwang ,  Fang He ,  Rajesh Kumar Subaschandrabose

IPC: C07K16/10 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/1018 ,  A61K2039/505 ,  A61K2039/544 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11

Abstract: The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H7 influenza using murine mAb 11B9, mAb 62 or fragments thereof. The present invention further relates to methods and kits for determining, identifying and/or quantifying (a) influenza A hemagglutinin in a sample or vaccine or (b) an antibody against influenza A hemagglutinin.

公开(公告)号：US09115188B2

公开(公告)日：2015-08-25

申请号：US13897725

申请日：2013-05-20

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED ,  NATIONAL INSTITUTE OF HEALTH RESEARCH AND DEVELOPMENT (NIHRD)-MINISTRY OF Health of the Republic of Indonesia

Inventor： Hong Liang Qian ,  Fang He ,  Siti Fadilah Supari ,  Hwei-Sing Kwang

IPC: A61K39/42 ,  C12Q1/70 ,  C07K16/10 ,  G01N33/53 ,  G01N33/569

CPC classification number: C07K16/1018 ,  A61K39/42 ,  C07K2317/24 ,  C07K2317/76 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11

Abstract: Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus H5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.

Abstract translation: 提供了特异于禽流感病毒H5亚型血凝素糖蛋白构象表位的单克隆抗体和相关结合蛋白。 该抗体可用于标本中H5亚型AIV的检测和治疗。