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公开(公告)号：US08642073B2
公开(公告)日：2014-02-04
申请号：US11653434
申请日：2007-01-11
申请人： Raphael J. Mannino , Susan Gould-Fogerite , Sara L. Krause-Elsmore , David Delmarre , Ruying Lu
发明人： Raphael J. Mannino , Susan Gould-Fogerite , Sara L. Krause-Elsmore , David Delmarre , Ruying Lu
IPC分类号： A61K9/127
CPC分类号： A61K9/1277 , A61K9/1274 , A61K31/00 , A61K31/135 , A61K31/167 , A61K31/395 , A61K31/60 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , G01N33/5091
摘要： Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
摘要翻译： 公开了用于制备耳蜗和耳蜗组合物的新方法，其包括在溶剂存在下将货物部分引入脂质体。 还公开了包括聚集抑制剂和任选的货物部分的耳蜗和耳蜗组合物。 另外，公开了包括质子化货物部分，二价金属阳离子和负电荷脂质的无水耳蜗。 还公开了使用本发明的耳蜗组合物的方法，包括施用方法。
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2.发明申请Integrative protein-DNA cochleate formulations and methods for transforming cells 审中-公开整合型蛋白质-DNA耳蜗制剂和转化细胞的方法公开(公告)号：US20050129661A1
公开(公告)日：2005-06-16
申请号：US11042598
申请日：2005-01-24
IPC分类号： A61K9/127 , A61K48/00 , C07K14/015 , C12N15/864 , C12N15/88 , C12N15/90 , C12N15/861
CPC分类号： C12N15/86 , A61K9/127 , A61K9/1274 , A61K48/00 , A61K48/0025 , C07K14/005 , C12N15/88 , C12N15/907 , C12N2750/14122 , C12N2750/14143
摘要： An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.
摘要翻译： 将整合的DNA载体和对DNA具有亲和力的一种或多种病毒蛋白质包装在耳蜗沉淀物中。 整合DNA载体含有一个或多个优选位于蛋白质的DNA底物之间的治疗性核苷酸序列。 在与靶细胞的脂质双层接触时，耳蜗载体结构将一种或多种治疗性核苷酸序列和一种或多种蛋白质递送至靶细胞的内部。 进入细胞后，蛋白促进了治疗性核苷酸序列整合到宿主细胞的基因组中。
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公开(公告)号：US20050013855A1
公开(公告)日：2005-01-20
申请号：US10822235
申请日：2004-04-09
申请人： Susan Gould-Fogerite , Raphael Mannino , Patrick Ahl , Gaofeng Shang , Zi Chen , Sara Krause-Elsmore
发明人： Susan Gould-Fogerite , Raphael Mannino , Patrick Ahl , Gaofeng Shang , Zi Chen , Sara Krause-Elsmore
IPC分类号： A61K9/00 , A61K9/127 , A61K31/7048 , A61K38/00 , A61K47/48 , C12N15/11 , C12N15/113 , A61K48/00 , C07H21/02
CPC分类号： A61K9/127 , A61K9/1274 , A61K31/7048 , A61K31/7088 , A61K38/00 , A61K47/6919 , C07H21/02 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/3233 , C12N2310/53 , C12N2320/32 , C12Y102/01012
摘要： Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
摘要翻译： 本文公开了新的siRNA-耳蜗和吗啉代 - 耳蜗组合物。 还公开了制备和使用siRNA-耳蜗和吗啉代 - 耳蜗组合物的方法。
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公开(公告)号：US20080242625A1
公开(公告)日：2008-10-02
申请号：US11578187
申请日：2005-04-11
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02
CPC分类号： A61K9/127 , A61K9/1274 , A61K31/7048 , A61K31/7088 , A61K38/00 , A61K47/6919 , C07H21/02 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/3233 , C12N2310/53 , C12N2320/32 , C12Y102/01012
摘要： The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein.
摘要翻译： 本发明涉及包含核苷酸的耳蜗组合物。 核苷酸通常可以通过接头连接到耳蜗组分或亲脂性尾部。 另外或替代地，核苷酸可以与转染剂相关联。 本发明还包括制备和使用本文提供的组合物的方法。
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公开(公告)号：US20050013854A1
公开(公告)日：2005-01-20
申请号：US10822230
申请日：2004-04-09
IPC分类号： A61K9/127 , A61K31/00 , A61K31/7048 , A61K31/70 , C12N15/88
CPC分类号： A61K9/1277 , A61K9/1274 , A61K31/00 , A61K31/135 , A61K31/167 , A61K31/395 , A61K31/60 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , G01N33/5091
摘要： Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
摘要翻译： 公开了用于制备耳蜗和耳蜗组合物的新方法，其包括在溶剂存在下将货物部分引入脂质体。 还公开了包括聚集抑制剂和任选的货物部分的耳蜗和耳蜗组合物。 另外，公开了包括质子化货物部分，二价金属阳离子和负电荷脂质的无水耳蜗。 还公开了使用本发明的耳蜗组合物的方法，包括施用方法。
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公开(公告)号：US06340591B1
公开(公告)日：2002-01-22
申请号：US09210578
申请日：1998-12-14
IPC分类号： C12N1563
CPC分类号： C12N15/86 , A61K9/127 , A61K9/1274 , A61K48/00 , A61K48/0025 , C07K14/005 , C12N15/88 , C12N15/907 , C12N2750/14122 , C12N2750/14143
摘要： An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.
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公开(公告)号：US6165502A
公开(公告)日：2000-12-26
申请号：US188120
申请日：1998-11-09
申请人： James M. Oleske , Thomas N. Denny , Anthony J. Scolpino , Eleonora Feketeova , Susan Gould-Fogerite , Raphael J. Mannino
发明人： James M. Oleske , Thomas N. Denny , Anthony J. Scolpino , Eleonora Feketeova , Susan Gould-Fogerite , Raphael J. Mannino
IPC分类号： A61K9/00 , A61K9/127 , A61K38/00 , A61K39/00 , A61K39/002 , A61K39/21 , A61P31/18 , A61P33/00 , A61P37/02
CPC分类号： A61K9/1271 , A61K2039/55555 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y10S424/812 , Y10S436/829
摘要： A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.
摘要翻译： 可用于制备自体疫苗的蛋白质 - 脂质囊泡包括患者特异性抗原，佐剂或免疫调节剂和脂质载体。 此外，期望包括带负电的脂质成分。 自体疫苗可用于治疗慢性疾病的个体，包括慢性传染病和肿瘤。 可治疗的慢性感染性疾病包括由人体免疫缺陷病毒感染引起的疾病。
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公开(公告)号：US20120178793A1
公开(公告)日：2012-07-12
申请号：US13424282
申请日：2012-03-19
CPC分类号： A61K9/1274 , A61K31/7088 , A61K47/6919 , C07H21/02 , C07H21/04
摘要： The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may he associated with a transfection agent. The present invention also includes methods for making and using, the compositions provided herein.
摘要翻译： 本发明涉及包含核苷酸的耳蜗组合物。 核苷酸通常可以通过接头连接到耳蜗组分或亲脂性尾部。 另外或替代地，核苷酸可以与转染剂相关联。 本发明还包括制备和使用本文提供的组合物的方法。
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公开(公告)号：US20080009457A1
公开(公告)日：2008-01-10
申请号：US11653093
申请日：2007-01-11
申请人： Susan Gould-Fogerite , Raphael Mannino , Patrick Ahl , Gaofeng Shang , Zi Chen , Sara Krause-Elsmore
发明人： Susan Gould-Fogerite , Raphael Mannino , Patrick Ahl , Gaofeng Shang , Zi Chen , Sara Krause-Elsmore
IPC分类号： A61K31/7052 , A61P17/00 , A61P19/00 , A61P25/00 , A61P3/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P7/00 , A61P9/00 , C12N5/00
CPC分类号： A61K9/127 , A61K9/1274 , A61K31/7048 , A61K31/7088 , A61K38/00 , A61K47/6919 , C07H21/02 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/3233 , C12N2310/53 , C12N2320/32 , C12Y102/01012
摘要： Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
摘要翻译： 本文公开了新的siRNA-耳蜗和吗啉代 - 耳蜗组合物。 还公开了制备和使用siRNA-耳蜗和吗啉代 - 耳蜗组合物的方法。
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公开(公告)号：US20070237814A1
公开(公告)日：2007-10-11
申请号：US11653434
申请日：2007-01-11
IPC分类号： A61K9/127
CPC分类号： A61K9/1277 , A61K9/1274 , A61K31/00 , A61K31/135 , A61K31/167 , A61K31/395 , A61K31/60 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , G01N33/5091
摘要： Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
摘要翻译： 公开了用于制备耳蜗和耳蜗组合物的新方法，其包括在溶剂存在下将货物部分引入脂质体。 还公开了包括聚集抑制剂和任选的货物部分的耳蜗和耳蜗组合物。 另外，公开了包括质子化货物部分，二价金属阳离子和负电荷脂质的无水耳蜗。 还公开了使用本发明的耳蜗组合物的方法，包括施用方法。
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