公开(公告)号：US5834015A

公开(公告)日：1998-11-10

申请号：US712020

申请日：1996-09-11

申请人： James M. Oleske ,  Thomas N. Denny ,  Anthony J. Scolpino ,  Eleonora Feketeova ,  Susan Gould-Fogerite ,  Raphael J. Mannino

发明人： James M. Oleske ,  Thomas N. Denny ,  Anthony J. Scolpino ,  Eleonora Feketeova ,  Susan Gould-Fogerite ,  Raphael J. Mannino

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/21 ,  A61P31/18 ,  A61P33/00 ,  A61P37/02

CPC分类号： A61K9/1271 ,  A61K2039/55555 ,  Y10S424/812 ,  Y10S436/829

摘要： A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.

公开(公告)号：US6165502A

公开(公告)日：2000-12-26

申请号：US188120

申请日：1998-11-09

申请人： James M. Oleske ,  Thomas N. Denny ,  Anthony J. Scolpino ,  Eleonora Feketeova ,  Susan Gould-Fogerite ,  Raphael J. Mannino

发明人： James M. Oleske ,  Thomas N. Denny ,  Anthony J. Scolpino ,  Eleonora Feketeova ,  Susan Gould-Fogerite ,  Raphael J. Mannino

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K38/00 ,  A61K39/00 ,  A61K39/002 ,  A61K39/21 ,  A61P31/18 ,  A61P33/00 ,  A61P37/02

CPC分类号： A61K9/1271 ,  A61K2039/55555 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y10S424/812 ,  Y10S436/829

摘要： A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.

摘要翻译： 可用于制备自体疫苗的蛋白质 - 脂质囊泡包括患者特异性抗原，佐剂或免疫调节剂和脂质载体。 此外，期望包括带负电的脂质成分。 自体疫苗可用于治疗慢性疾病的个体，包括慢性传染病和肿瘤。 可治疗的慢性感染性疾病包括由人体免疫缺陷病毒感染引起的疾病。