公开(公告)号：US20250043619A1

公开(公告)日：2025-02-06

申请号：US18714048

申请日：2022-11-29

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Benjamin HATTON ,  Raphael KAY ,  John Alstan JAKUBIEC

IPC: E06B3/67 ,  E06B9/24

Abstract: A device for regulating light passing through the device comprises a multi-layered stack. The stack comprises a first layer and a second layer. The first layer and the second layer allow the light to pass through the first layer and the second layer. A first fluid channel is defined between the first layer and the second layer. The first fluid channel allows the light to pass through the first fluid channel. A first fluid is operably received into the first fluid channel and operably withdrawn from the first fluid channel.

公开(公告)号：US20250032606A1

公开(公告)日：2025-01-30

申请号：US18709405

申请日：2022-11-14

Applicant: David S. CAMPO ,  Richard URBANOWICZ ,  Mounir ABOUHAIDAR ,  UNIVERSITY HEALTH NETWORK ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  UNIVERSITY OF LIVERPOOL ,  CENTERS FOR DISEASE CONTROL AND PREVENTION ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

Inventor： David S. CAMPO ,  Richard A. URBANOWICZ ,  Mounir G. ABOUHAIDAR ,  Alexander I. MOSA ,  Jordan J. FELD

IPC: A61K39/29 ,  A61K39/00 ,  A61K39/385 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  G16B15/30 ,  G16B40/30

Abstract: There is described herein polyvalent HCV vaccines, preferably comprising SEQ ID Nos. 1-5. There is also described herein methods of designing polyvalent vaccines.

公开(公告)号：US20250019844A1

公开(公告)日：2025-01-16

申请号：US18901648

申请日：2024-09-30

Applicant: TOTALENERGIES ONETECH ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Jianan Erick HUANG ,  Fengwang LI ,  Adnan OZDEN ,  David SINTON ,  Edward SARGENT

IPC: C25B11/081 ,  C25B3/26 ,  C25B13/08 ,  C25B15/031

Abstract: The present disclosure relates to an electrode for CO2 electroreduction in an acidic electrolyte comprising cation species, the electrode comprising: a substrate, a metal-based catalyst material, and a cation-augmenting material; wherein the cation-augmenting material comprises an acidic group exchanging protons with the cation species of the acidic electrolyte so as to increase a concentration of the cation species at a surface of the electrode.

公开(公告)号：US20240415014A1

公开(公告)日：2024-12-12

申请号：US18671224

申请日：2024-05-22

Applicant: The Governing Council of the University of Toronto

Inventor： Alán Aspuru-Guzik ,  AkshatKumar Nigam ,  Robert Pollice ,  Pascal Thomas Friederich ,  Benjamin Bangjie Ding

IPC: H10K85/60 ,  C07D487/04 ,  C07D519/00 ,  C09K11/06 ,  H01S5/36

Abstract: The present application relates to compounds (e.g. Formulae III, V, VII, IX, and XII) having a negative singlet-triplet gap and a positive oscillator strength. The present application also relates to use of the compounds of the present application in photocatalysis and in OLEDs as emitters and/or dopants.

公开(公告)号：US20240389588A1

公开(公告)日：2024-11-28

申请号：US18665989

申请日：2024-05-16

Applicant: The Governing Council of the University of Toronto

Inventor： Peter John Roy ,  Sean Harrington ,  Andrew Burns ,  Jacob Edward Pyche ,  Genna M. Luciani ,  Jessica Knox ,  Mark Lautens ,  Ken Loon Choo

IPC: A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  A01P5/00 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61P33/10

Abstract: The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (III) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection.

公开(公告)号：US20240351032A1

公开(公告)日：2024-10-24

申请号：US18708902

申请日：2022-11-10

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Sebastian VON DER ECKEN ,  Aaron R. WHEELER ,  Michael Dean CHAMBERLAIN ,  Alexandros SKLAVOUNOS

IPC: B01L3/00 ,  B81B1/00

CPC classification number: B01L3/502715 ,  B01L3/502784 ,  B01L2300/041 ,  B01L2300/0645 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/0415 ,  B81B1/00

Abstract: A microfluidics device comprises a cover mounted to an addressing structure. The cover has a working surface on one side, and a plurality of electrodes on its other side. The electrodes may be used for manipulation of fluid droplets on the working surface. The electrodes are connected to a voltage source by way of the addressing structure to selectively apply voltage to individual ones of the plurality of electrodes.

公开(公告)号：US20240262919A1

公开(公告)日：2024-08-08

申请号：US17254248

申请日：2019-06-19

Applicant: ShanghaiTech University ,  The Governing Council of the University of Toronto

Inventor： Sachedv S. Sidhu ,  Donghui Wu ,  Guohua James Pan ,  Shusu Liu ,  Shane Miersch ,  Haiming Huang

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92

Abstract: Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

公开(公告)号：US12054562B2

公开(公告)日：2024-08-06

申请号：US17205311

申请日：2021-03-18

Applicant: The Governing Council of the University of Toronto

Inventor： Gang Lei ,  Beverley Anne Orser

IPC: C07K7/08 ,  A61K9/00 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61P25/00 ,  C07K7/06 ,  C07K14/005 ,  C07K14/47 ,  C07K16/18 ,  C07K14/705

CPC classification number: C07K7/08 ,  A61K9/0019 ,  A61K38/08 ,  A61K38/10 ,  A61P25/00 ,  C07K7/06 ,  C07K14/005 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/10

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of α5 subunit of α5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to α5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

公开(公告)号：US20240254642A1

公开(公告)日：2024-08-01

申请号：US18564001

申请日：2022-05-25

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Xue WANG ,  Edward SARGENT

IPC: C25B11/097 ,  C07C29/48 ,  C25B3/07 ,  C25B3/25 ,  C25B3/26 ,  C25B11/032

CPC classification number: C25B11/097 ,  C07C29/48 ,  C25B3/07 ,  C25B3/25 ,  C25B3/26 ,  C25B11/032

Abstract: The present disclosure relates to the manufacturing and use of co-doped multi-metallic electrocatalysts for electroreduction of CO or CO2 to produce n-propanol. The co-doped multi-metallic electrocatalyst includes Cu as well as Ag and a secondary dopant, such as Ruthenium (Ru), Rhodium (Rh), Iridium (Ir), Palladium (Pd), Gold (Au) or Platinum (Pt). The co-doped multi-metallic electrocatalyst can be manufactured using a two-stage method where Cu nanoparticles are first doped with Ru and then doped with Ag. The co-doped multi-metallic electrocatalysts facilitate adsorption of CO, C1-C1 coupling, C1-C2 coupling and certain kinetics for the production of propanol by electroreduction with good selectivity at high current densities.

公开(公告)号：US11992685B2

公开(公告)日：2024-05-28

申请号：US17161086

申请日：2021-01-28

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Hossein Kassiri Bidhendi ,  Nima Soltani ,  Roman Genov

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/145 ,  A61B5/318 ,  A61B5/369 ,  A61B5/398 ,  A61N1/04 ,  A61N1/05 ,  A61N1/375 ,  A61N1/378 ,  G06N20/00

CPC classification number: A61N1/36135 ,  A61B5/0031 ,  A61B5/0042 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/318 ,  A61B5/369 ,  A61B5/398 ,  A61B5/4094 ,  A61B5/686 ,  A61B5/7225 ,  A61B5/7275 ,  A61B5/7282 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36 ,  A61N1/36031 ,  A61N1/36034 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/3756 ,  G06N20/00 ,  A61N1/37514 ,  A61N1/3787

Abstract: There is provided a neurostimulator and method for delivering to a subject a stimulation in response to a predicted or detected condition. The neurostimulator including: a power circuit for providing electrical power to the neurostimulator; a recording array having a plurality of electrodes for recording a plurality of neurophysiological signals corresponding to a plurality of sites of the subject; a signal processor configured to: determine a phase synchrony among the neurophysiological signals; and associate selected phase synchrony calculations with the prediction or detection of a neurological or neurophysiological condition; and one or more stimulators for delivering to the subject a stimulation in response to the predicted or detected condition.