公开(公告)号：US12215370B2

公开(公告)日：2025-02-04

申请号：US16956431

申请日：2018-12-21

Applicant: The Governing Council of the University of Toronto

Inventor： Keith Pardee ,  Evan Amalfitano ,  Margot Karlikow

IPC: C12P19/02 ,  C12P19/14 ,  C12Q1/54

Abstract: Described are methods for generating a reporter molecule in response to a target analyte in a cell-free system. A synthetic biological circuit is used to modify the level of the reporter molecule in response to the presence of the target analyte. The reporter molecule may be glucose or another molecule readily detected using a device such as glucose monitor or other portable sensor. Also provided are kits comprising a cell-free system with a synthetic biological circuit that generates or consumes a reporter molecule in response to a target analyte.

公开(公告)号：US20250013155A1

公开(公告)日：2025-01-09

申请号：US18744433

申请日：2024-06-14

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Oleg CHEBOTAREV ,  Alisa UGODNIKOV ,  Craig SIMMONS

IPC: G03F7/20 ,  G01N33/487 ,  G03F7/16

Abstract: Methods and devices for microfluidic porous membrane electrical cell-substrate impedance sensing (ECIS) are provided. Efficient methods of fabricating ECIS membrane electrodes as well as ECIS membrane electrodes having lower electrode resistance values, which allow for higher sensitivity measurements.

公开(公告)号：US20240424140A1

公开(公告)日：2024-12-26

申请号：US18642049

申请日：2024-04-22

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Maryam FAIZ ,  Justine BAJOHR ,  Mershad SADRIA ,  Gary BADER

IPC: A61K48/00 ,  A61K38/17 ,  C12N15/86

Abstract: The present application provides methods for production of induced oligodendrocyte lineage cells (IOLCs) from donor astrocytes comprising contact the donor astrocytes with a polynucleotide comprising a nucleic acid encoding a single transcription factor (TF), wherein the single TF is Olig2, Sox10, or Nkx6.2. Also provided are pharmaceutical compositions for performing the method and associated uses thereof.

公开(公告)号：US12135325B2

公开(公告)日：2024-11-05

申请号：US17024913

申请日：2020-09-18

Applicant: The Governing Council of the University of Toronto ,  University Health Network

Inventor： Mark Nitz ,  Landon J. Edgar ,  Bradly G. Wouters ,  David Hedley ,  Lisa M. Willis ,  Matthew A. Lumba ,  Hanuel Park ,  Ravi N. Vellanki

IPC: C07D345/00 ,  C07D421/06 ,  C07H15/04 ,  G01N33/569 ,  G01N33/58

Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.

公开(公告)号：US20240343744A1

公开(公告)日：2024-10-17

申请号：US18757341

申请日：2024-06-27

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Andrei K. YUDIN ,  Aleksandra HOLOWNIA

IPC: C07F5/02 ,  C07F5/04

CPC classification number: C07F5/025 ,  C07F5/04

Abstract: There is provide herein a compound of Formula (3):






wherein R1, R2, R3, R4, R5, R6, and R7 are each independently H or an organic group.

公开(公告)号：US20240327549A1

公开(公告)日：2024-10-03

申请号：US18575268

申请日：2022-07-08

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  STANDARD BIOTOOLS CANADA INC.

Inventor： Mitchell A. Winnik ,  Edmond Chi Ngae Wong ,  Yefeng Zhang ,  Daniel Majonis ,  Peng Liu

IPC: C08F8/42 ,  C08F20/38

CPC classification number: C08F8/42 ,  C08F20/38

Abstract: The present disclosure relates to compounds of Formula I, element tags comprising soft metals, and methods and kits therefore for performing mass cytometry.

公开(公告)号：US20240281693A1

公开(公告)日：2024-08-22

申请号：US18034444

申请日：2021-10-19

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Artur Izmaylov ,  Abhinav Anand ,  Jakob Kottmann ,  Alan Aspuru-Guzik ,  Robert Lang ,  Tzu-ching Yen

IPC: G06N10/60 ,  G06F17/14 ,  G06N10/20 ,  G06N10/40

CPC classification number: G06N10/60 ,  G06F17/14 ,  G06N10/20 ,  G06N10/40

Abstract: A computer-implemented method and system for implementing a n-fold fermionic excitation generator using linear combination of directly differentiable operators on a quantum computer. Computer-readable data is generated and stored which when executed on the quantum computer, causes a quantum circuit of the quantum computer to execute repeatedly to perform a sequence of operations that implements the unitary (I) generated by a fermionic n-fold excitation operator G. The Gradient with respect to the angle Θ of arbitrary expectation values involving the unitary operation can, in the general case, be evaluated by four expectation values obtained from replacing the corresponding unitary with fermionic shift operations (II). Fermionic shift operations can be constructed through the original unitary and unitary operations generated by the nullspace projector P0 of the fermionic excitation generator. Other operators and generators are disclosed.

公开(公告)号：US20240271294A1

公开(公告)日：2024-08-15

申请号：US18567238

申请日：2022-06-10

Applicant: TOTALENERGIES ONETECH ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： David SINTON ,  Edward SARGENT ,  Ke XIE ,  Rui Kai MIAO

IPC: C25B3/03 ,  C25B3/26 ,  C25B9/21 ,  C25B11/032 ,  C25B13/08 ,  C25B15/027 ,  C25B15/031

CPC classification number: C25B3/03 ,  C25B3/26 ,  C25B9/21 ,  C25B11/032 ,  C25B13/08 ,  C25B15/027 ,  C25B15/031

Abstract: An electroreduction system for converting carbon oxides selected from CO, CO2 or any mixture thereof into multicarbon (C2+) products. the system comprising a cathodic compartment having a reactant inlet and comprising a cathode, the cathode comprising a catalyst layer that is contactable with a catholyte solution; an anodic compartment having a product outlet to release the C2+ products, the anodic compartment comprising an anode and being configured to accommodate a flowing anolyte solution; and a bipolar membrane being positioned between the cathodic compartment and the anodic compartment, the bipolar membrane comprising an interfacial layer defined between a cation-exchange layer and a anion-exchange layer, wherein the cathodic compartment is configured to accommodate a stationary catholyte layer between the catalyst layer of the cathode and the CEL, the stationary catholyte layer comprising the catholyte solution.

公开(公告)号：US20240235810A1

公开(公告)日：2024-07-11

申请号：US18388687

申请日：2023-11-10

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Shaveer Bajpeyi ,  Glenn Gulak

IPC: H04L9/00 ,  H04L9/06

CPC classification number: H04L9/008 ,  H04L9/0618

Abstract: Cryptographic processor chips, systems and associated methods are disclosed. In one embodiment, a cryptographic processor is disclosed. The cryptographic processor includes a first cryptographic processing module to perform a first logic operation. The first cryptographic processing module includes first input circuitry to receive ciphertext input symbols. A first pipeline stage performs a first operation on the ciphertext input symbols and generates a first stage output. On-chip memory temporarily stores the first stage output and feeds the first stage output to a second pipeline stage in a pipelined manner. The second pipeline stage is configured to perform a second operation on the first stage output in a pipelined manner with respect to the first pipeline stage.

公开(公告)号：US20240220829A1

公开(公告)日：2024-07-04

申请号：US18087897

申请日：2022-12-23

Applicant: Huawei Technologies Canada Co., Ltd. ,  The Governing Council of the University of Toronto

Inventor： Chenghao Hu ,  Baochun Li ,  Zhixiang Chi ,  Yuanhao Yu ,  Yang Wang ,  Jin Tang

IPC: G06N5/04

CPC classification number: G06N5/04

Abstract: Methods and modules for accelerating inference computations in transformer models using edge devices includes partitioning inputs for each layer and synchronizing between transformer layers. A method includes receiving a transformer input, partitioning the transformer input into two or more first-stage divisions, processing each first-stage division into a processed first-stage division, and combining the processed first-stage divisions into a first output. A module includes a computing device for partitioning a transformer input into two or more divisions, transmitting each of the divisions, and receiving processed divisions, as well as two or more transformer processing units, each for receiving a division from the computing device, processing the division into a processed division, and sending the processed division to the computing device.