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    COMPOSITION AND METHOD FOR ARRESTING BLOOD FLOW AND FOR FORMING A PERSISTENT MICROBIAL BARRIER
    86.
    发明申请
    COMPOSITION AND METHOD FOR ARRESTING BLOOD FLOW AND FOR FORMING A PERSISTENT MICROBIAL BARRIER 审中-公开
    用于制备血液流动和形成一个不间断微生物障碍物的组合物和方法

    公开(公告)号：US20140120052A1

    公开(公告)日：2014-05-01

    申请号：US14147143

    申请日：2014-01-03

    申请人： BIOLIFE, LLC

    发明人： JOHN HEN ,  JOHN ALFRED THOMPSON ,  TALMADGE KELLY KEENE ,  MARK TRAVI

    IPC分类号： A61K31/795

    CPC分类号： A61K31/795 ,  B01J39/05 ,  B01J39/20

    摘要： A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa.

    摘要翻译： 用于促进出血性伤口部位愈合的组合物和方法。 该组合物优选包括基本上无水的阳离子交换树脂形式，其当在血液上施用时，提供对伤口中的浮游微生物和生物膜的抗微生物剂。 当应用足够量时，树脂还能够通过与存在于​​血液和其它体液中的阳离子进行脱水和离子交换来提供对浮游微生物和生物膜的持续和持续的抗微生物。 当树脂的浓度至少为26mg / ml时，提供MRSA，MRSE和绿脓假单胞菌生物活性降低> 3log。

    Thiol-containing compounds for the removal of elements from tissues and formulations therefor
    89.
    发明授权
    Thiol-containing compounds for the removal of elements from tissues and formulations therefor 有权
    用于从组织中除去元素的硫醇化合物及其制剂

    公开(公告)号：US08575218B2

    公开(公告)日：2013-11-05

    申请号：US13041798

    申请日：2011-03-07

    申请人： Boyd E. Haley ,  David A. Atwood ,  Niladri Gupta

    发明人： Boyd E. Haley ,  David A. Atwood ,  Niladri Gupta

    IPC分类号： A01N37/12 ,  A01N37/10 ,  A01N43/00

    CPC分类号： A61K31/198 ,  A61K31/216 ,  A61K31/695 ,  A61K31/795 ,  B01D53/64 ,  B01D2253/106 ,  B01D2253/25 ,  B01D2257/602 ,  B01D2258/0283 ,  B01D2258/0291 ,  C07F7/1804

    摘要： Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.

    摘要翻译： 公开了用于改善重金属毒性和/或氧化应激的方法和药物制剂，其包括施用根据本公开的药学有效量的配体。 配体具有以下通式：其中R1包括苯，吡啶，吡啶-4-酮，萘，蒽，菲或烷基，R2包括氢，烷基，芳基，羧基，羧酸酯，有机基团或生物基团 R 3包括烷基，芳基，羧基，羧酸酯，有机基团或生物基团，X包括氢，锂，钠，钾，铷，铯，ium，烷基，芳基，羧基，羧酸酯，硫代磷酸酯，N 乙酰半胱氨酸，巯基乙酸，巯基丙酸，硫代水杨酸，有机基团或生物基团，n独立地等于1-10，m = 1-6，Y包括氢，聚合物，二氧化硅或二氧化硅负载的底物，Z包括氢，烷基， 芳基，羧基，羧酸酯，羟基，NH 2，HSO 3，卤素，羰基，有机基团，生物基团，聚合物，二氧化硅或二氧化硅负载的基质。