- 专利标题： Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
-
申请号： US14053725申请日： 2013-10-15
-
公开(公告)号： US09301974B2公开(公告)日： 2016-04-05
- 发明人: Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
- 申请人： Relypsa, Inc.
- 申请人地址： US CA Redwood City
- 专利权人： Relypsa, Inc.
- 当前专利权人： Relypsa, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Senniger Powers LLP
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K33/06 ; A61K9/50 ; A61K31/75 ; A61K31/785 ; A61K31/74 ; A61K9/16
摘要：
The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
公开/授权文献
信息查询
