公开(公告)号：US3539494A

公开(公告)日：1970-11-10

申请号：US3539494D

申请日：1967-08-02

申请人： PRETORIUS VICTOR ,  HAHN HANS HELMUT

发明人： PRETORIUS VICTOR ,  HAHN HANS HELMUT

IPC分类号： G01N30/02 ,  B01D11/02 ,  B01D11/04 ,  B01D15/00 ,  B01D15/08 ,  B01D53/18 ,  G01N27/416 ,  G01N27/447 ,  G01N27/49 ,  G01N30/06 ,  G01N30/14 ,  G01N30/18 ,  G01N30/22 ,  G01N30/34 ,  G01N30/38 ,  G01N30/50 ,  G01N30/56 ,  G01N30/62 ,  G01N30/64 ,  G01N30/84 ,  B01K5/00

CPC分类号： B01D69/10 ,  B01D11/02 ,  B01D11/04 ,  B01D15/3885 ,  B01D53/18 ,  G01N27/447 ,  G01N30/06 ,  G01N30/14 ,  G01N30/34 ,  G01N30/38 ,  G01N30/50 ,  G01N30/56 ,  G01N30/64 ,  G01N30/84 ,  G01N2030/387 ,  G01N2030/626 ,  G01N2030/645 ,  G01N30/02 ,  G01N2030/0035 ,  B01D15/361

公开(公告)号：US11796519B2

公开(公告)日：2023-10-24

申请号：US17432595

申请日：2020-02-27

申请人： SANOFI

发明人： Pierre Guibal

IPC分类号： G01N30/72 ,  G01N30/62

CPC分类号： G01N30/7233 ,  G01N2030/626

摘要： The present application concerns a process for quantifying polysorbates in a sample by implementing a LC-MS analysis with an internal standard, and the process for monitoring degradation of polysorbates in such sample.

公开(公告)号：US20180372696A1

公开(公告)日：2018-12-27

申请号：US15780829

申请日：2015-12-04

申请人： SHIMADZU CORPORATION

发明人： Kazuma MAEDA

IPC分类号： G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC分类号： G01N30/724 ,  G01N27/62 ,  G01N30/72 ,  G01N30/7273 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/107 ,  H01J49/165

摘要： A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

公开(公告)号：US20180140970A1

公开(公告)日：2018-05-24

申请号：US15728390

申请日：2017-10-09

申请人： PERKINELMER HEALTH SCIENCES, INC.

发明人： Nathan L. Porter ,  Anthony D. Rands ,  Randal W. Waite ,  Kenneth D. Nemelka ,  Chad A. Grant

IPC分类号： B01D15/12 ,  B01D59/44 ,  G01N30/30 ,  G01N15/08 ,  G01F1/72 ,  G01N30/96 ,  G01N1/40

CPC分类号： B01D15/12 ,  B01D59/44 ,  G01F1/72 ,  G01N1/2214 ,  G01N1/24 ,  G01N1/40 ,  G01N15/0826 ,  G01N30/30 ,  G01N30/96 ,  G01N2001/2297 ,  G01N2030/025 ,  G01N2030/128 ,  G01N2030/626

摘要： Certain configurations of devices and systems which are configured to draw a selected volume of an air sample into a trap are described. In some examples, the devices and systems comprise a pump and a mass flow sensor to draw a selected volume of the air sample through a trap even where variable restriction occurs.

公开(公告)号：US09804609B2

公开(公告)日：2017-10-31

申请号：US14380641

申请日：2012-02-22

申请人： Xiao-Sheng Guan ,  Robert C. Henderson

发明人： Xiao-Sheng Guan ,  Robert C. Henderson

IPC分类号： G05D7/06 ,  G01N30/32 ,  G01F25/00

CPC分类号： G05D7/0635 ,  G01F25/0007 ,  G01N30/32 ,  G01N2030/626

摘要： An MFC includes: a proportional valve; a mass flow sensor; a first flow line connecting from an outlet of the proportional valve through the mass flow sensor to an exit line; a second flow line joining the first flow line at a first junction located upstream of the mass flow sensor and at a second junction located downstream of the mass flow sensor; a switching valve placed such that the switching valve can regulate a flow of a gas through the first flow line or the second flow line; and a control device connected to provide a feedback control loop for regulating the proportional valve based on signals measured by the mass flow sensor, wherein the control device includes a program for keeping a rate of a flow exiting the exit line substantially constant when the flow is through the second flow line.

公开(公告)号：US07422625B2

公开(公告)日：2008-09-09

申请号：US11852655

申请日：2007-09-10

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a unit flow per unit pressure based on a ratio of the flow rate and the differential pressure. In certain embodiments, the flow rate at the outlet is established by controlling the flow rate of the gas. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 所公开的系统和方法包括提供具有入口和出口的容器，用于使载气通过该容器; 确定出口处的已知流速的入口和出口之间的压差; 并且基于流量和压差的比率确定单位压力的单位流量。 在某些实施例中，通过控制气体的流量来建立出口处的流量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于在输出处的气体压力与环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US20080014652A1

公开(公告)日：2008-01-17

申请号：US11718896

申请日：2005-06-03

申请人： Antonio Caprai

发明人： Antonio Caprai

IPC分类号： G01N30/02 ,  B01J19/00

CPC分类号： G01N30/32 ,  G01N30/16 ,  G01N30/466 ,  G01N30/66 ,  G01N2030/025 ,  G01N2030/322 ,  G01N2030/625 ,  G01N2030/626

摘要： Apparatus for analysing a gas sample comprising a variable volume chamber (8) in fluodynamic connection through a line (21-22) with a sample holding container (30), in which the gas sample is contained, and through a line (11-19) with a plurality of gaschromatographic instruments, for example two (51, 52). These instruments carry out the quantitative and qualitative analysis of the gas sample according to known techniques. Preliminarily, by vacuum pumps (60), the line (11-23) and the variable volume chamber (8) are vacuumed. Then valves (41, 43, 45) are closed in order to exclude the portions of line set between valves (41, 43) and six-way valves (75, 76) respectively, and a delivery duct (23) of the pump (65), which is the general pumping means of the line. Since the variable volume chamber (8) is under vacuum when it is connected to the sample holding container (30), it attracts a certain quantity of gas sample inside. The pressure of the chamber (8), and then of the sample holding container (30), are monitored instantly by a pressure sensor (25), for example an analogic reader (35). Once chosen the column (51, 52) that can be used for carrying out the qualitative and quantitative analysis of the gas sample, the corresponding valve (41, 43) is open. Then, starting from a known volume and pressure, the gas sample is compressed, or expanded, changing the volume of the chamber (8), in order to bring the pressure of the gas same within a predetermined range of values for which the response of the detector (70, 71) is linear.

摘要翻译： 一种用于分析气体样品的装置，包括通过具有样品保持容器（30）的管线（21-22）的流体动力学连接的可变容积室（8），其中容纳有气体样品，并且通过管线（11-19） ）与多个气相色谱仪器，例如两个（51,52）。 这些仪器根据已知技术对气体样品进行定量和定性分析。 最初，通过真空泵（60），线（11-23）和可变容积室（8）被抽真空。 然后关闭阀门（41,43,45），以分别排除阀门（41,43）和六通阀（75,76）之间的管路部分和泵的输送管道（23） 65），这是线路的一般泵送装置。 由于可变容积室（8）在与样品保持容器（30）连接时处于真空状态，因此吸入一定量的气体样品。 通过压力传感器（25），例如模拟读取器（35）立即监测腔室（8）的压力和样品保持容器（30）的压力。 一旦选择了可用于对气体样品进行定性和定量分析的色谱柱（51,52），相应的阀门（41,43）就被打开。 然后，从已知的体积和压力开始，气体样品被压缩或膨胀以改变腔室（8）的体积，以便使气体的压力相同于预定范围的值， 检测器（70,71）是线性的。

公开(公告)号：US07267709B2

公开(公告)日：2007-09-11

申请号：US11559760

申请日：2006-11-14

申请人： Andrew Tipler ,  Neil T. Plant

发明人： Andrew Tipler ,  Neil T. Plant

IPC分类号： B01D53/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。

公开(公告)号：US20060263901A1

公开(公告)日：2006-11-23

申请号：US11403527

申请日：2006-04-13

申请人： Andrew Tipler ,  Christopher Mazza ,  David Scott

发明人： Andrew Tipler ,  Christopher Mazza ,  David Scott

IPC分类号： G01N1/00

CPC分类号： G01N30/12 ,  G01N1/2226 ,  G01N1/405 ,  G01N30/24 ,  G01N2001/2229 ,  G01N2030/025 ,  G01N2030/121 ,  G01N2030/202 ,  G01N2030/626 ,  Y10T436/117497 ,  Y10T436/17 ,  Y10T436/25 ,  Y10T436/25875

摘要： A method for introducing standard gas into a sample vessel is generally disclosed comprising providing a vessel containing a sample gas and a receptacle with a vessel port, such as sampling needle, pressurizing the vessel with a carrier gas, and introducing a volume of standard gas into the flow path of the carrier gas being used to pressurize the vessel when the vessel port of the receptacle is located within the vessel. In some embodiments, a rotary valve is loaded with the standard gas, and the valve is brought into fluid communication with the flow path of the carrier gas when the vessel port is within the vessel.

摘要翻译： 通常公开了将标准气体引入样品容器的方法，该方法包括提供容纳样品气体的容器和具有容器端口的容器，例如采样针，用载气对容器加压，并将一定体积的标准气体引入 当容器的容器端口位于容器内时，载气的流动路径用于对容器加压。 在一些实施例中，旋转阀装载有标准气体，并且当容器端口在容器内时阀与载气的流动路径流体连通。

公开(公告)号：US07111494B2

公开(公告)日：2006-09-26

申请号：US11072829

申请日：2005-03-04

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/02

CPC分类号： G01N30/89 ,  G01N15/0826 ,  G01N30/32 ,  G01N30/60 ,  G01N2030/324 ,  G01N2030/524 ,  G01N2030/626 ,  G01N2030/525

摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.

摘要翻译： 公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。 在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定 使用基于输出温度和环境温度的比率的因子的环境温度。