公开(公告)号：USRE50171E1

公开(公告)日：2024-10-15

申请号：US17682960

申请日：2022-02-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Byron Kieser

IPC: B01D59/44

CPC classification number: B01D59/44

Abstract: Improved systems, apparatus, methods, and programming useful for the automated analysis of complex compounds using mass spectrometers. Systems, apparatus, methods, and programming according to the invention provide for the automatic determination by a controller 54 of a mass spectrometer 14, 214 of an analysis operation to be implemented using the mass spectrometer, the analysis operation adapted specifically for analysis of one or more substances based contained within a compound based on identification of the compound and/or substances provided by a user of the spectrometer, and a database 66 or other library of information concerning suitable processes or process steps for analyzing substances.

公开(公告)号：US20180076013A1

公开(公告)日：2018-03-15

申请号：US15690617

申请日：2017-08-30

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Christopher BRODIE ,  Oliver KRACHT ,  Alexander HARTWIG ,  Michael KRUMMEN ,  Johannes SCHWIETERS

IPC: H01J49/04 ,  H01J49/42

CPC classification number: H01J49/0468 ,  B01D59/44 ,  G01N30/12 ,  G01N30/30 ,  G01N30/7206 ,  G01N31/12 ,  G01N2030/125 ,  G01N2030/3076 ,  H01J49/0422 ,  H01J49/426

Abstract: A sample preparation apparatus for an elemental analysis system comprising a sample combustion and/or reduction and/or pyrolysis arrangement for receiving a sample of material to be analysed, and producing therefrom a sample gas flow containing atoms, molecules and/or compounds; a gas chromatography (GC) column into which the sample gas flow is directed; a heater for heating at least a part of the GC column; and a controller for controlling the heater. The controller is configured to control the heater so as to increase the temperature of at least the part of the GC column whilst the sample gas flow in the GC column elutes.

公开(公告)号：US09793477B2

公开(公告)日：2017-10-17

申请号：US14137840

申请日：2013-12-20

Applicant: The Regents of the University of California

Inventor： Daojing Wang ,  Pan Mao ,  Hung-Ta Wang ,  Peidong Yang

IPC: H01L49/00 ,  B01D59/44 ,  G01N30/72 ,  B01D3/00 ,  H01J49/04 ,  H01J49/00 ,  H01J49/16 ,  B01L3/00

CPC classification number: H01L49/00 ,  B01D59/44 ,  B01L3/5027 ,  G01N30/72 ,  G01N30/7206 ,  H01J49/0018 ,  H01J49/04 ,  H01J49/167

Abstract: The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.

公开(公告)号：US09330892B2

公开(公告)日：2016-05-03

申请号：US14323275

申请日：2014-07-03

Applicant: Spectro Analytical Instruments GmbH

Inventor： Dirk Ardelt ,  Ulrich Heynen ,  Adi A. Scheidemann

IPC: H01J49/02 ,  H01J49/32 ,  B01D59/44

CPC classification number: H01J49/025 ,  B01D59/44 ,  H01J49/322

Abstract: An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an ICP mass spectrometer with an ICP ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a Mattauch-Herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet.

Abstract translation: 能够同时测量相关的和大的或全质谱范围的无机质谱仪可以包括合适的离子源（例如，具有ICP离子源的ICP质谱仪），离子转移区域，离子光学器件，用于将离子从 等离子体束，具有一组带电粒子束光学器件的Mattauch-Herzog型质谱仪，用于在入射狭缝之前调节离子束，以及基本上与地电位分离并与磁体的电位分离的固态多通道检测器 。

公开(公告)号：US09110016B2

公开(公告)日：2015-08-18

申请号：US13991295

申请日：2011-12-02

Applicant: Frédéric Chartier ,  Valérie Geersten ,  Laurent Vio ,  Gérard Crétier

Inventor： Frédéric Chartier ,  Valérie Geersten ,  Laurent Vio ,  Gérard Crétier

IPC: G01N27/447 ,  H01J49/10 ,  B01D59/42 ,  B01D59/44 ,  G01N30/88

CPC classification number: G01N27/44721 ,  B01D59/42 ,  B01D59/44 ,  G01N27/447 ,  G01N27/44717 ,  G01N27/44756 ,  G01N2030/8868 ,  H01J49/105

Abstract: A method for isotope measurement of charged species contained in a solution to be analyzed, particularly charged species having an isobaric interference, has the following consecutive steps: a) in the capillary of a capillary electrophoresis device, the solution to be analyzed is inserted contiguously between a terminating electrolyte and a leading electrolyte that, respectively, are placed after the inlet and before the outlet of the capillary and contain ions of the same charge but with mobility inferior and superior to those of said species; b) separating the species by using the capillary electrophoresis device according to the isotachophoresis mode; then c) in the continuity of the preceding step, performing an isotope measurement of the species detected in the form of a substantially constant amplitude signal by using an inductively coupled plasma mass spectrometer (ICPMS) connected by direct coupling with the capillary electrophoresis device.

Abstract translation: 在待分析溶液中所含的带电物质的同位素测量方法，特别是具有等压干扰的带电物质的方法具有以下连续步骤：a）在毛细管电泳装置的毛细管中，待分析溶液相邻插入 末端电解质和前导电解质，其分别放置在毛细管的入口之后并且在毛细管的出口之前并且含有相同电荷的离子，但其迁移率低于和优于所述物质的离子; b）根据等电泳方式使用毛细管电泳装置分离物种; 然后c）在前述步骤的连续性中，通过使用通过与毛细管电泳装置直接耦合连接的电感耦合等离子体质谱仪（ICPMS），以基本上恒定幅度信号的形式检测的物种进行同位素测量。

公开(公告)号：US09053919B2

公开(公告)日：2015-06-09

申请号：US11639373

申请日：2006-12-13

Applicant: Stephen A. Lammert ,  Samuel E. Tolley ,  Jeffrey L. Jones ,  Randall W. Waite ,  Edgar D. Lee ,  Milton L. Lee

Inventor： Stephen A. Lammert ,  Samuel E. Tolley ,  Jeffrey L. Jones ,  Randall W. Waite ,  Edgar D. Lee ,  Milton L. Lee

IPC: H01J49/36 ,  H01J49/04 ,  H01J49/42 ,  H01J49/00 ,  B01D59/44

CPC classification number: H01J49/424 ,  B01D59/44 ,  H01J49/0013 ,  H01J49/422 ,  H01J49/4225 ,  H01J49/423

Abstract: A scaled down version of a toroidal radio frequency (RF) ion trap mass analyzer operating with RF trapping voltages on the order of 1 kVp-p yet despite the reduced dimensions, retains roughly the same ion trapping volume as conventional 3D quadrupole ion traps, wherein the curved geometry enables construction of a compact mass analyzer and easy interface with conventional electron multipliers.

Abstract translation: 尽管尺寸减小，虽然尺寸减小，仍然使用大约1 kVp-p的RF捕获电压操作的环形射频（RF）离子阱质量分析仪的缩小版本保持与常规3D四极离子阱大致相同的离子捕获体积，其中 弯曲几何使得能够构建紧凑的质量分析器并且与传统的电子倍增器容易接合。

公开(公告)号：US08822917B2

公开(公告)日：2014-09-02

申请号：US14147928

申请日：2014-01-06

Applicant: Riken ,  Shimadzu Corporation

Inventor： Koji Ueda ,  Atsuhiko Toyama

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0027 ,  B01D59/44 ,  G01N33/6848 ,  G01N33/6854 ,  G01N2400/00 ,  G01N2440/38 ,  H01J49/00 ,  Y10T436/173076 ,  Y10T436/24

Abstract: In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile.

公开(公告)号：US08809773B2

公开(公告)日：2014-08-19

申请号：US11886890

申请日：2006-03-22

Applicant: Mark E. Bier

Inventor： Mark E. Bier

IPC: H01J49/00 ,  B01D59/44 ,  G01N1/00 ,  G01N1/28

CPC classification number: B01D59/44 ,  G01N1/00 ,  G01N1/22 ,  G01N1/28 ,  G01N35/1095

Abstract: The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.

Abstract translation: 所公开的方法和装置在大气压力下将膜界面直接耦合到质谱仪。 膜可以是毛细管或片状，并且允许将液体或气体样品引入膜的一侧，同时膜的另一侧用可容易地用于大气压电离源的溶液洗涤。 挥发性分子渗透通过合适的膜，例如聚二甲基硅氧烷（PDMS），混合到合适的溶剂中并被电离。 由于管理摘要的规则，本摘要不应用于解释索赔。

公开(公告)号：US08653448B1

公开(公告)日：2014-02-18

申请号：US13943130

申请日：2013-07-16

Applicant: Riken ,  Shimadzu Corporation

Inventor： Koji Ueda ,  Atsuhiko Toyama

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0027 ,  B01D59/44 ,  G01N33/6848 ,  G01N33/6854 ,  G01N2400/00 ,  G01N2440/38 ,  H01J49/00 ,  Y10T436/173076 ,  Y10T436/24

Abstract: In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile.

Abstract translation: 为了提供能够确定具有高检测灵敏度的聚糖结构的分析方法，本发明的方法包括以下步骤：以各种CID能量进行三重四极杆质谱; 产生能量分辨曲线，其包括表示（i）CID能量的值和（ii）特定类型的产物离子的测量量之间的关系的收益率曲线; 准备参考分布图，以及通过将能量分辨分布与参考分布进行比较来识别测试材料的聚糖结构。

公开(公告)号：US08497471B2

公开(公告)日：2013-07-30

申请号：US13232861

申请日：2011-09-14

Applicant: William F. Haddon ,  Nigel J. Clarke

Inventor： William F. Haddon ,  Nigel J. Clarke

IPC: B01D59/44

CPC classification number: B01D59/44 ,  G01N30/7233 ,  G01N33/6848 ,  G01N2030/387 ,  G01N2030/8831

Abstract: Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample.

Abstract translation: 描述了用于测量样品中甲基化TPMT酶产物的量的方法。 更具体地，描述了用于在测试样品中利用质谱技术检测和定量6-MMP或同位素标记的6-MMP的质谱法，并且使用这些方法来测定样品中存在的TPMT酶的活性。