公开(公告)号：US20150268222A1

公开(公告)日：2015-09-24

申请号：US14437275

申请日：2013-11-15

Applicant: CORNING INCORPORATED

Inventor： Oberon Denaci Deichmann ,  Ye Fang ,  Ann MeeJin Ferrie ,  Haibei Hu ,  Qi Wu

IPC: G01N33/50 ,  G01N15/14 ,  G01N21/31

CPC classification number: G01N33/5014 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/3151 ,  G01N21/7743 ,  G01N33/502 ,  G01N33/5061 ,  G01N2015/0065 ,  G01N2015/144 ,  G01N2015/1454

Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.

Abstract translation: 一种无标记的谐振波导光栅生物传感器成像系统，用于在不存在和存在药物分子的情况下测量培养的心肌细胞的搏动模式和动态质量再分配（DMR）信号。 本公开还提供了一种使用成像仪系统分析心肌细胞的搏动模式和DMR信号以评估药物诱导的心脏毒性的方法。

公开(公告)号：US20150260689A1

公开(公告)日：2015-09-17

申请号：US14691721

申请日：2015-04-21

Applicant: Los Alamos National Security, LLC

Inventor： Gregory Kaduchak ,  Michael D. Ward

IPC: G01N29/14 ,  G01N33/483

CPC classification number: G01N29/14 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  G01N15/1404 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/4833 ,  G01N2001/4094 ,  G01N2015/1081 ,  G01N2015/1415 ,  G01N2015/142 ,  G01N2015/149

Abstract: The present invention is a method and apparatus for acoustically manipulating one or more particles.

Abstract translation: 本发明是用于声学地操纵一个或多个颗粒的方法和装置。

公开(公告)号：US09134301B2

公开(公告)日：2015-09-15

申请号：US13298847

申请日：2011-11-17

Applicant: Robert M. Archer ,  Frank Hsiung ,  Paul Patt

Inventor： Robert M. Archer ,  Frank Hsiung ,  Paul Patt

IPC: G01N33/50 ,  G01N15/06 ,  G01N15/14 ,  G01N15/02

CPC classification number: G01N33/5094 ,  G01N15/0606 ,  G01N15/1463 ,  G01N2015/0288 ,  G01N2015/149

Abstract: Adherent cells bearing characteristics that are detectable only in the adherent state can be sorted on the basis of these characteristics independently of their adherent state, by applying a transformable label to the entire population of cells, both those bearing the characteristics of interest and those not, in their adherent state and identifying the locations of the cells of interest on the adherent surface. The cells of interest, or all cells other than those of interest, are then selectively treated to transform the labels and achieve differentiation between the cells of interest and the remaining cells. All cells are then released from the adherent state and sorted in the same manner as non-adherent cells but on the basis of whether the labels are transformed or not transformed.

Abstract translation: 具有仅在粘附状态下可检测的特征的粘附细胞可以根据这些特征独立于其粘附状态进行分类，通过将可变形标记应用于整个细胞群体，具有感兴趣特征的那些， 在其粘附状态下并且识别感兴趣的细胞在贴壁表面上的位置。 然后选择性地处理感兴趣的细胞或所有不同于感兴趣的细胞的细胞，以转化标记并实现感兴趣的细胞和剩余的细胞之间的分化。 然后将所有细胞从粘附状态释放并以与非贴壁细胞相同的方式进行分选，但是基于标记是否被转化或未转化。

公开(公告)号：US20150241322A1

公开(公告)日：2015-08-27

申请号：US14635738

申请日：2015-03-02

Applicant: Monsanto Technology LLC

Inventor： Kevin L. Deppermann ,  Lee Yannakakis ,  Andrew M. Singleton ,  Angela R. Cargill ,  David W. Finley ,  Brian J. Forinash ,  Allen N. Ondes ,  Sam R. Eathington ,  Heather M. Forbes ,  Bruce J. Schnicker ,  Jason K. Bull

IPC: G01N1/28 ,  A01C1/02 ,  A01C1/00

CPC classification number: A01C1/025 ,  A01C1/00 ,  C12Q1/6895 ,  C12Q2600/13 ,  G01N1/04 ,  G01N1/28 ,  G01N1/286 ,  G01N15/1459 ,  G01N15/1463 ,  G01N24/08 ,  G01N2015/0019 ,  G01N2015/149 ,  G01N2015/1497

Abstract: An automated method for analyzing seeds generally includes collecting image data from individual seeds using a seed sampling system, determining at least one characteristic of each of the individual seeds based on the collected image data, and removing tissue from each of the individual seeds using the seed sampling system. The method also includes, prior to removing the tissue sample from each of the individual seeds, adjusting at least one operational parameter of the seed sampling system based on the at least one characteristic of the seed from which the tissue is to be removed to thereby allow for generally consistent removal of tissue from each of the individual seeds. In some aspects, the method further includes analyzing the tissue removed from the seeds for presence or absence of at least one characteristic, and selecting seeds based on presence or absence of the at least one characteristic.

Abstract translation: 用于分析种子的自动化方法通常包括使用种子采样系统从个体种子收集图像数据，基于收集的图像数据确定每个个体的至少一个特征，以及使用种子从每个个体种子中移除组织 抽样系统 该方法还包括在从每个个体种子去除组织样本之前，基于要从其中去除组织的种子的至少一个特征来调整种子采样系统的至少一个操作参数，从而允许 用于从每个单独种子中大体一致地去除组织。 在一些方面，所述方法还包括分析从种子中去除的组织存在或不存在至少一种特征，以及基于存在或不存在至少一种特征来选择种子。

公开(公告)号：US20150204785A1

公开(公告)日：2015-07-23

申请号：US14423771

申请日：2013-08-29

Applicant: The University of Tokyo

Inventor： Soo Hyeon Kim ,  Hiroyuki Noji ,  Ryota Iino ,  Jun Ohta ,  Takashi Tokuda ,  Kiyotaka Sasagawa ,  Toshihiko Noda

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/502769 ,  B01L3/50853 ,  B01L2200/0673 ,  B01L2300/041 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2400/0481 ,  G01N15/1463 ,  G01N21/6454 ,  G01N2015/1006 ,  G01N2021/6439 ,  Y10T436/143333

Abstract: There are provided a detector and a detection method capable of detecting a biological sample with high sensitivity. A detector is provided with a microchamber array including a plurality of storage sections to be filled with a hydrophilic solvent containing a biological sample; and an image sensor in which picture elements are disposed corresponding to the storage sections, wherein the microchamber array includes a flow channel in communication with openings of the storage sections; a hydrophobic solvent supply unit arranged in continuity with the flow channel; and a through-hole which allows the hydrophilic solvent to enter and exit the flow channel, and the hydrophobic solvent supply unit flows a hydrophobic solvent into the flow channel by an externally-applied force.

Abstract translation: 提供了能够以高灵敏度检测生物样品的检测器和检测方法。 检测器设置有微室阵列，其包括多个存储部分，以填充含有生物样品的亲水溶剂; 以及图像传感器，其中对应于所述存储部分设置有图像元素，其中所述微室阵列包括与所述存储部分的开口连通的流动通道; 疏水性溶剂供应单元，与所述流动通道连续布置; 以及允许亲水性溶剂进入流出通道的通孔，并且疏水性溶剂供给单元通过外部施加的力将疏水性溶剂流入流路。

公开(公告)号：US20150177041A1

公开(公告)日：2015-06-25

申请号：US14557626

申请日：2014-12-02

Applicant: Honda Motor Co., Ltd.

Inventor： Yuichi FUKUCHI ,  Masato NAKAJIMA

IPC: G01F1/704 ,  G01N15/14

CPC classification number: G01F1/704 ,  G01F1/7086 ,  G01N15/1436 ,  G01N15/1463 ,  G01N2015/0046 ,  G01N2015/0053 ,  G01N2015/1075 ,  G01P3/36

Abstract: A particle photographing device 2 includes: an illumination optical system 13 that illuminates particles with sheet-like illumination light based on laser light from an end of an optical fiber 7; an imaging portion 6 that images the illuminated particles; and a regulation portion 14 that changes the distance between the end of the optical fiber 7 and the illumination optical system 13.

Abstract translation: 粒子拍摄装置2包括：照明光学系统13，其利用来自光纤7的端部的基于激光的片状照明光照射粒子; 成像部分6，其对被照射的颗粒进行成像; 以及改变光纤7的端部与照明光学系统13之间的距离的调节部分14。

公开(公告)号：US20150160175A1

公开(公告)日：2015-06-11

申请号：US14620534

申请日：2015-02-12

Applicant: Xtralis Technologies Ltd.

Inventor： Ron KNOX ,  Karl BOETTGER ,  Kemal AJAY

IPC: G01N33/00 ,  G01N21/17 ,  G08B17/12

CPC classification number: G01N21/49 ,  G01N15/1463 ,  G01N21/17 ,  G01N21/532 ,  G01N33/0031 ,  G01N2021/1765 ,  G01N2201/06113 ,  G01S7/4873 ,  G01S7/4876 ,  G01S17/026 ,  G01S17/87 ,  G01S17/95 ,  G08B17/103 ,  G08B17/107 ,  G08B17/117 ,  G08B17/125 ,  G08B25/10 ,  G08B29/043 ,  G08B29/185 ,  G08B29/24 ,  Y02A90/19

Abstract: The invention provides use of one or more emitted beams of radiation (16), for example, laser beam(s), in combination with an image capturing means (14), for example, one or more video cameras and/or optical elements to detect particles (30), for example, smoke particles, located in an open space (12).

Abstract translation: 本发明提供了与图像捕获装置（14），例如一个或多个摄像机和/或光学元件结合使用一个或多个发射的辐射束（16），例如激光束， 检测位于开放空间（12）中的颗粒（30），例如烟雾颗粒。

公开(公告)号：US20150147772A1

公开(公告)日：2015-05-28

申请号：US14607766

申请日：2015-01-28

Applicant: Yoshiko YOSHIHARA ,  Tomoharu KIYUNA

Inventor： Yoshiko YOSHIHARA ,  Tomoharu KIYUNA

IPC: G06K9/00 ,  G01N33/50

CPC classification number: G06K9/00134 ,  A61B2576/00 ,  G01N15/1463 ,  G01N21/251 ,  G01N33/5091 ,  G01N33/574 ,  G01N2015/1006 ,  G01N2015/1465 ,  G06F19/00 ,  G06K9/00127 ,  G06K9/0014 ,  G06K2209/05 ,  G06T7/0012 ,  G06T2207/10008 ,  G06T2207/10024 ,  G06T2207/20021 ,  G06T2207/20104 ,  G06T2207/30024 ,  G06T2207/30242

Abstract: The present invention provides an information processing apparatus capable of selecting a region of cancer cells in any tissue sample image and easily and accurately counting the number of the cancer cells. The information processing apparatus is an information processing apparatus 100 including: an acquisition unit 110 for acquiring image data obtained by reading a tissue sample image 150 obtained by putting a mark 151 specifying a selected area 152 on an image obtained by immunostaining and then imaging a biological tissue; and a counting unit 120 for counting the number of cancer cells in the selected area 152 specified by the mark 151 based on the image data of the tissue sample image 150 acquired by the acquisition unit 110, wherein a diagnosis based on the tissue sample image 150 is supported.

Abstract translation: 本发明提供一种信息处理装置，其能够选择任何组织样本图像中的癌细胞的区域，并且容易且准确地计数癌细胞的数量。 该信息处理设备是一种信息处理设备100，包括：获取单元110，用于获取通过读取组织样本图像获得的图像数据，该组织样本图像150通过将指定选择区域152的标记151放置在通过免疫染色获得的图像上，然后对生物 组织; 以及计数单元120，用于基于由获取单元110获取的组织样本图像150的图像数据，对由标记151指定的所选区域152中的癌细胞数进行计数，其中基于组织样本图像150 被支持。

公开(公告)号：US20150118706A1

公开(公告)日：2015-04-30

申请号：US14524211

申请日：2014-10-27

Applicant: SYSMEX CORPORATION

Inventor： Shota TATEYAMA ,  Masanori KAWANO ,  Masatsugu OZASA

IPC: C12Q1/04 ,  G01N15/14 ,  G01N33/493

CPC classification number: C12Q1/04 ,  G01N15/14 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/493 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1493 ,  G01N2015/1497

Abstract: Disclosed is a urine sample analyzer for analyzing particles contained in a urine sample and outputting analytical results. The analyzer includes a flow cell that accepts a measurement specimen, the measurement specimen comprising a urine sample mixed with a reagent, a light irradiation unit positioned to irradiate the flowing measurement specimen with light, a light detector that detects light from individual particles in the flowing measurement specimen, and a data processor that receives signal from the light detector, processes the signal to obtain parameter information corresponding to a length of a cell cluster, and classifies fungi in the measurement specimen into groups by using the parameter information.

Abstract translation: 公开了一种用于分析尿样中包含的颗粒并输出分析结果的尿样分析仪。 所述分析装置包括容纳测定试样的流通池，所述测定试样具有与试剂混合的尿液样本，定位成用光照射所述流动的测定试样的光照射单元，检测来自流动中的各个粒子的光的光检测器 测量样本和从光检测器接收信号的数据处理器，处理信号以获得与细胞簇的长度相对应的参数信息，并且通过使用参数信息将测量样本中的真菌分类成组。

公开(公告)号：US20150108367A1

公开(公告)日：2015-04-23

申请号：US14579442

申请日：2014-12-22

Applicant: Singulex, Inc.

Inventor： Richard Livingston

IPC: G01N21/64 ,  G01N21/01 ,  G01N15/14

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。