公开(公告)号：US06417244B1

公开(公告)日：2002-07-09

申请号：US09687447

申请日：2000-10-13

Applicant: Stephen T. Wellinghoff ,  Hong Dixon ,  Henry R. Rawls ,  Barry K. Norling

Inventor： Stephen T. Wellinghoff ,  Hong Dixon ,  Henry R. Rawls ,  Barry K. Norling

IPC: C08J328

CPC classification number: C08F2/44 ,  A61K6/027 ,  A61K8/0204 ,  A61K8/29 ,  A61K8/365 ,  A61K2800/413 ,  A61Q17/04 ,  B01J13/02 ,  B82Y5/00 ,  B82Y30/00 ,  C01B13/32 ,  C01G23/003 ,  C01G35/00 ,  C01P2004/64 ,  A61K6/083 ,  C08L33/00

Abstract: Metal oxide and metal oxide-silica nanoparticles are disclosed wherein the surfaces thereof are complexed with a polymerizable, biocompatible, heterocyclic base. Polymerizable compositions are prepared by loading such nanoparticles into acrylate based monomer matrices, which compositions can then be photocured into X-ray opaque, transparent or translucent solids. Methods are disclosed for forming such complexed nanoparticles and compositions and for using such compositions as medical or dental restoratives.

Abstract translation: 公开了金属氧化物和金属氧化物 - 二氧化硅纳米颗粒，其中其表面与可聚合的生物相容的杂环碱基配合。 通过将这样的纳米颗粒装载到基于丙烯酸酯的单体基质中制备可聚合的组合物，然后将该组合物光固化成X射线不透明，透明或半透明的固体。 公开了形成这种络合的纳米颗粒和组合物以及使用这种组合物如医疗或牙科修复剂的方法。

公开(公告)号：US06410765B1

公开(公告)日：2002-06-25

申请号：US09690527

申请日：2000-10-17

Applicant: Stephen T. Wellinghoff ,  Hong Dixon ,  Henry R. Rawls ,  Barry K. Norling

Inventor： Stephen T. Wellinghoff ,  Hong Dixon ,  Henry R. Rawls ,  Barry K. Norling

IPC: C07F908

CPC classification number: A61K6/027 ,  A61K8/0241 ,  A61K8/29 ,  A61K8/365 ,  A61K2800/413 ,  A61K2800/612 ,  A61Q17/04 ,  B01J13/02 ,  B82Y5/00 ,  B82Y30/00 ,  C01B13/32 ,  C01G23/003 ,  C01G35/00 ,  C01P2004/64 ,  C08F2/44 ,  A61K6/083 ,  C08L33/00

Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.

Abstract translation: 公开了用膦酸酯的甲硅烷基酯和其与丙烯酸酯类单体的复合材料官能化的两性纳米尺寸金属氧化物颗粒，包括在环境温度下可光聚合的液晶单体。 还公开了通过使金属氧化物与膦酸酯的甲硅烷基酯在非水溶剂和惰性气氛的存在下反应而进行官能化的方法，以及制备复合物的方法，其中官能化颗粒与 丙烯酸酯基基体单体，包括在环境温度下可光聚合的液晶单体。 进一步公开了牙科修复方法，其中将复合材料应用于牙齿并进行光聚合。

公开(公告)号：US5752833A

公开(公告)日：1998-05-19

申请号：US634852

申请日：1996-04-19

Applicant: Masao Yamamoto

Inventor： Masao Yamamoto

IPC: A61C1/00 ,  A61C5/04

CPC classification number: A61K6/033 ,  A61C5/04 ,  A61K6/027 ,  A61K6/04 ,  A61K6/08 ,  A61C1/0046

Abstract: A method for effectively repairing damage to dental enamel. In a repairing process, employed is a repairing agent containing a filling component strong adherable to dental enamel when heated by laser beam irradiation.

Abstract translation: 一种有效修复牙釉质损伤的方法。 在修复过程中，采用激光束照射加热时含有能够粘附于牙釉质的填充成分的修复剂。

公开(公告)号：US5236495A

公开(公告)日：1993-08-17

申请号：US747978

申请日：1991-08-21

Applicant: Tsuneo Manabe ,  Hirosi Usui ,  Yasuko Osaki

Inventor： Tsuneo Manabe ,  Hirosi Usui ,  Yasuko Osaki

IPC: C03B9/48 ,  C03B19/02 ,  C03B32/02 ,  C03C10/00 ,  C03C10/02

CPC classification number: C03B9/48 ,  A61K6/0005 ,  A61K6/0094 ,  A61K6/025 ,  A61K6/0255 ,  A61K6/027 ,  A61K6/0273 ,  A61K6/0612 ,  A61K6/0625 ,  A61K6/0643 ,  C03B19/02 ,  C03B32/02 ,  C03C10/00

Abstract: A calcium phosphate type glass-ceramic which comprises from 64 to 72% by weight of phosphorus oxide in terms of P.sub.2 O.sub.5, from 13 to 20% by weight of calcium oxide in terms of CaO, from 6 to 13% by weight of strontium oxide in terms of SrO, and from 3 to 15% by weight in total of at least one member selected from the group consisting of aluminum oxide, cerium oxide and lanthanum oxide respectively in terms of Al.sub.2 O.sub.3, Ce.sub.2 O.sub.3 and La.sub.2 O.sub.3, a molar ratio of (CaO+SrO)/P.sub.2 O.sub.5 being 0.78-0.86.

公开(公告)号：US5082808A

公开(公告)日：1992-01-21

申请号：US593299

申请日：1990-10-04

Applicant: Tohru Nonami ,  Nobuo Yasui

Inventor： Tohru Nonami ,  Nobuo Yasui

IPC: A61C8/00 ,  A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61K6/027 ,  A61L27/12 ,  A61L27/42 ,  C04B35/447 ,  C04B35/80

CPC classification number: A61L27/12 ,  A61C8/0012 ,  A61F2/28 ,  A61K6/0044 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/0215 ,  A61K6/024 ,  A61K6/027 ,  A61K6/033 ,  A61L27/425 ,  C04B35/447 ,  C04B35/803 ,  A61F2002/30968 ,  A61F2310/00293

Abstract: A ceramic material for use as artificial bone and dental root is provided which takes the form of a composite sintered body comprising crystalline calcium phosphate grains as a matrix and inorganic whiskers dispersed therein. An intermediate layer containing elements in either one or both of the whiskers and the grains intervenes between the whiskers and the grains. The material has physical toughness and strength as well as biomedical affinity. The material is prepared by mixing calcium phosphate and a whisker-forming material or whiskers and sintering the mixture at a temperature of 800.degree. to 1600.degree. C., followed by slow cooling to allow formation of the intermediate layer.

Abstract translation: 提供了用作人造骨和牙根的陶瓷材料，其采用包含结晶磷酸钙颗粒作为基质和分散在其中的无机晶须的复合烧结体的形式。 包含晶须和晶粒之一或两者中的元素的中间层介于晶须和晶粒之间。 该材料具有物理韧性和强度以及生物医学亲和力。 该材料通过混合磷酸钙和晶须形成材料或晶须并在800℃至1600℃的温度下烧结混合物制备，然后缓慢冷却以形成中间层。

公开(公告)号：US4917702A

公开(公告)日：1990-04-17

申请号：US153885

申请日：1988-02-09

Applicant: Hans Scheicher ,  Eberhard Wendler

Inventor： Hans Scheicher ,  Eberhard Wendler

IPC: A61K6/00 ,  A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/36 ,  A61K6/033 ,  A61L24/00 ,  A61L26/00 ,  A61L27/00 ,  A61L27/12 ,  A61L27/32

CPC classification number: A61L27/12 ,  A61K6/0008 ,  A61K6/0073 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/027 ,  A61K6/0668 ,  A61L27/32 ,  A61F2/2803 ,  A61F2/30767 ,  A61F2/36 ,  A61F2/3662 ,  A61F2002/2853 ,  A61F2002/30677 ,  A61F2310/00293 ,  A61F2310/00796 ,  A61L2430/02

Abstract: This invention sets forth an agent for filling bone and tooth defects, for building up bone, for bone-contact layers and for the replacement of bones and the roots of teeth, which contains calcium phosphate apatite having carbonate and alkali portions, all ions being definedly integrated in the crystal lattice; use is optionally made together with additives and/or diluents both tolerated by the body. Furthermore, it sets forth the use of this apatite for filling bone and tooth defects, for building up bone, for bone-contact layers, as a replacement for bones and the roots of teeth and as an implant article consisting completely or partially of this apatite or consisting of a material known for implant articles and being coated completely or partially with a layer of this apatite.

Abstract translation: 本发明提出了一种用于填充骨骼和牙齿缺陷的物质，用于建立骨骼，用于骨接触层以及用于替换含有具有碳酸盐和碱性部分的磷酸钙磷灰石的骨骼和牙根，所有离子被定义为 集成在晶格中; 任选地与身体所容许的添加剂和/或稀释剂一起使用。 此外，它阐述了这种磷灰石用于填充骨和牙齿缺陷，用于建立骨骼，用于骨接触层，作为骨骼和牙根的替代物以及作为完全或部分由该磷灰石组成的植入物制品的用途 或由已知用于植入物品的材料组成，并且完全或部分地涂覆有该磷灰石层。

公开(公告)号：US4454258A

公开(公告)日：1984-06-12

申请号：US340689

申请日：1982-01-20

Applicant: Haruyuki Kawahara ,  Teruo Makita ,  Shozo Kudo ,  Takashi Funakoshi

Inventor： Haruyuki Kawahara ,  Teruo Makita ,  Shozo Kudo ,  Takashi Funakoshi

IPC: A61K6/027 ,  A61K6/08 ,  A61K6/083 ,  A61L24/00 ,  A61L27/16 ,  A61L27/44 ,  C08K3/28

CPC classification number: A61L27/446 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/0091 ,  A61K6/027 ,  A61K6/033 ,  A61L24/0089 ,  A61L27/16 ,  A61L27/44 ,  A61L2430/12

Abstract: Resin-forming material suitable for medical or dental use comprising tetramethylolmethane tri- or tetracrylate or tetramethylolmethane tri- or tetramethacrylate; and implant material suitable for medical or dental use comprising nitride of at least one member of metal selected from the group consisting of Group IVB, Group VB and Group VIB in the periodic table of elements and boron, aluminum and silicon and having Mohs' scale of hardness of at least 7.

公开(公告)号：US20180303587A1

公开(公告)日：2018-10-25

申请号：US15770220

申请日：2016-10-25

Applicant: Tokuyama Dental Corporation

Inventor： Junichiro YAMAGAWA ,  Tomonao SHIMIZU ,  Yuko NAGASAWA

IPC: A61C13/00 ,  A61C13/08 ,  A61C13/09 ,  C08K3/36 ,  C08K3/22 ,  A61K6/04 ,  A61K6/06 ,  A61K6/087 ,  C08J5/00 ,  B29C45/00

CPC classification number: A61C13/0022 ,  A61C13/0004 ,  A61C13/081 ,  A61C13/087 ,  A61C13/09 ,  A61K6/027 ,  A61K6/046 ,  A61K6/0612 ,  A61K6/087 ,  B29C45/0001 ,  B29C45/0055 ,  B29K2101/12 ,  B29K2105/16 ,  B29L2031/7532 ,  C08J5/00 ,  C08J2371/10 ,  C08K3/00 ,  C08K3/22 ,  C08K3/36 ,  C08K2003/2241 ,  C08L101/00

Abstract: A resin block that can be favorably used for obtaining dental prosthetics through the milling work, containing very little voids, having excellent property for being cut, exhibiting excellent appearance and mechanical strength, and without permitting the formation of defective products. The resin block contains a thermoplastic resin having a fluidizing temperature in a range of 310 to 500° C. and inorganic particles in an amount of 30 to 150 parts by mass per 100 parts by mass of said thermoplastic resin. The inorganic particles are at least one kind of inorganic oxide particles selected from the group consisting of silica particles, silica composite particles of silica and other metal oxides, titania particles, and titania composite particles of titania and other metal oxides. The resin block has a thick portion of a thickness of at least not less than 5 mm, and does not contain any void whose length is not less than 1.0 mm.

公开(公告)号：US09993394B2

公开(公告)日：2018-06-12

申请号：US15119053

申请日：2015-02-17

Applicant: KURARAY NORITAKE DENTAL INC.

Inventor： Hirotaka Kita ,  Michiya Kawana ,  Eiichi Terakawa

IPC: A61K6/08 ,  A61K6/02 ,  A61K6/083 ,  A61K6/027 ,  A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0005 ,  A61K6/0008 ,  A61K6/0052 ,  A61K6/027 ,  C08L33/10

Abstract: Provided is a dental restorative composition that has good handling properties when in the form of a paste having yet to be cured and that has light diffusion ability and transparency when in the form of a cured product. The dental restorative composition includes a polymerizable monomer, a polymerization initiator, an inorganic filler (C) having an average particle diameter of 0.1 to 1 μm, an organic-inorganic composite filler (D) having an average particle diameter of 1 μm or more and less than 10 μm, and an organic-inorganic composite filler (E) having an average particle diameter of 10 to 50 μm. An absolute value of a difference between a refractive index (Cd) of the inorganic filler (C) and a refractive index (Ad) of a polymer of the polymerizable monomer is 0.01 or less, an absolute value of a difference between the refractive index (Ad) and one of a refractive index (Dd) of the organic-inorganic composite filler (D) and a refractive index (Ed) of the organic-inorganic composite filler (E) is 0.01 or less, and an absolute value of a difference between the refractive index (Ad) and the other of the refractive index (Dd) and the refractive index (Ed) is 0.03 or more.

公开(公告)号：US09855196B2

公开(公告)日：2018-01-02

申请号：US14648536

申请日：2013-11-26

Applicant: KURARAY NORITAKE DENTAL INC.

Inventor： Takehiro Kameya ,  Hiroshige Ishino ,  Akiko Tsuji

IPC: A61K6/08 ,  A61K6/083 ,  A61C19/02 ,  A61K6/027 ,  A61K6/00 ,  A61C5/50

CPC classification number: A61K6/083 ,  A61C5/50 ,  A61C19/02 ,  A61K6/0005 ,  A61K6/0008 ,  A61K6/0017 ,  A61K6/0073 ,  A61K6/027 ,  A61K6/0276 ,  C08L33/10

Abstract: The present invention provides a dental curable composition suitable as a flowable composite resin. The dental curable composition, when in the form of a cured product, has excellent mechanical strength, polishability, and gloss retention, and, when in the form of a paste, has consistency appropriate for discharge through a needle attached to the tip of a syringe and exhibits good formability and handling properties after discharge through the needle. The present invention is a dental curable composition including: a polymerizable monomer (A); irregularly-shaped inorganic particles (B) having an average particle diameter of 0.1 to 0.3 μm and surface-treated with a silane coupling agent having a particular structure; and inorganic ultrafine particles (C) having an average particle diameter of 5 to 50 nm and surface-treated with a silane coupling agent having a particular structure, the dental curable composition containing 92.5 to 98 weight % of the irregularly-shaped inorganic particles (B) and 2 to 7.5 weight % of the inorganic ultrafine particles (C) relative to the amount of total inorganic particles and having a consistency of 25 to 55.