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    Electrophoresis standards, methods and kits
    62.
    发明授权
    Electrophoresis standards, methods and kits 有权
    电泳标准，方法和试剂盒

    公开(公告)号：US08945361B2

    公开(公告)日：2015-02-03

    申请号：US11524630

    申请日：2006-09-20

    Applicant: Erik Gentalen ,  Daniel J. Suich

    Inventor： Erik Gentalen ,  Daniel J. Suich

    IPC: G01N27/447 ,  C07K1/13 ,  C07K1/26 ,  C07K1/28 ,  C07K7/06 ,  C07K7/08

    CPC classification number: G01N27/44726 ,  C07K1/13 ,  C07K1/26 ,  C07K1/28 ,  C07K7/06 ,  C07K7/08 ,  G01N2550/00

    Abstract: Electrophoresis Compositions, methods and kits useful for, among other things, detecting, quantifying and/or characterizing analytes are provided. The compositions are useful as electrophoresis standards for determine the isoelectric point and molecular weight of an analyte. The electrophoresis standards generally comprise at least one label moiety and one or more reactive moieties that when activated attach the standard to a substrate.

    Abstract translation: 提供了用于检测，量化和/或表征分析物的组合物，方法和试剂盒。 该组合物可用作用于测定分析物的等电点和分子量的电泳标准品。 电泳标准品通常包含至少一个标记部分和一个或多个反应性部分，当活化时将标准物附着到基底上。

    Rapid protein labeling and analysis
    65.
    发明授权
    Rapid protein labeling and analysis 有权
    快速蛋白标记和分析

    公开(公告)号：US08609423B2

    公开(公告)日：2013-12-17

    申请号：US12122607

    申请日：2008-05-16

    Applicant: Thomas Diller ,  George Hanson ,  Bethany Sutton ,  Timothy Updyke

    Inventor： Thomas Diller ,  George Hanson ,  Bethany Sutton ,  Timothy Updyke

    IPC: G01N33/68 ,  G01N33/00

    CPC classification number: G01N33/582 ,  B33Y80/00 ,  G01N33/6803 ,  G01N2550/00

    Abstract: The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein. Following the labeling step, the proteins within the mixture can be separated and analyzed. In a further embodiment, a tag binding fluorogenic reagent that can bind to a tag on a tagged protein is added to specifically label the protein of interest.

    Abstract translation: 本发明提供用于在细胞裂解物或蛋白质混合物中标记，分离和分析蛋白质，特别是感兴趣的特定蛋白质的方法和组合物。 蛋白质用胺反应性或硫醇反应性荧光染料或胺反应性荧光试剂标记，其与位于蛋白质上的胺基团反应变为荧光。 在标记步骤之后，可以分离和分析混合物内的蛋白质。 在另一个实施方案中，加入可结合标记蛋白上的标签的标签结合荧光试剂以特异性标记所关注的蛋白质。

    Screening for neurotoxic amino acid associated with neurological disorders
    69.
    发明授权
    Screening for neurotoxic amino acid associated with neurological disorders 有权
    筛查与神经系统疾病相关的神经毒性氨基酸

    公开(公告)号：US07901895B2

    公开(公告)日：2011-03-08

    申请号：US11837899

    申请日：2007-08-13

    Applicant: Paul A Cox ,  Sandra Banack ,  Susan Murch

    Inventor： Paul A Cox ,  Sandra Banack ,  Susan Murch

    IPC: G01N33/48 ,  G01N33/02 ,  G01N33/18 ,  G01N33/53 ,  C12Q1/04

    CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

    Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定组织样品中的B-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者神经障碍或预测受试者发展神经障碍的可能性的方法 从主题获得。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

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