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    RAPID PROTEIN LABELING AND ANALYSIS
    4.
    发明申请
    RAPID PROTEIN LABELING AND ANALYSIS 审中-公开

    公开(公告)号：US20160054327A1

    公开(公告)日：2016-02-25

    申请号：US14688986

    申请日：2015-04-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Thomas Diller ,  Bethany Sutton ,  George Hanson ,  Timothy Updyke

    IPC: G01N33/58

    CPC classification number: G01N33/582 ,  B33Y80/00 ,  G01N33/6803 ,  G01N2550/00

    Abstract: The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein. Following the labeling step, the proteins within the mixture can be separated and analyzed. In a further embodiment, a tag binding fluorogenic reagent that can bind to a tag on a tagged protein is added to specifically label the protein of interest.

    Methods and Kits for Separation and Detection of Proteins in Biological Samples
    7.
    发明申请
    Methods and Kits for Separation and Detection of Proteins in Biological Samples 失效
    生物样品中蛋白质分离检测的方法和试剂盒

    公开(公告)号：US20110027802A1

    公开(公告)日：2011-02-03

    申请号：US12771351

    申请日：2010-04-30

    Applicant: Jennifer E. Van Eyk ,  Jeremy A.C. Simpson

    Inventor： Jennifer E. Van Eyk ,  Jeremy A.C. Simpson

    IPC: G01N33/566

    CPC classification number: G01N33/6803 ,  G01N33/52 ,  G01N33/6887 ,  G01N2333/4712 ,  G01N2550/00

    Abstract: Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells and in the early clinical diagnosis of myocardial damage by detection of myofilament proteins in serum of a subject.

    Abstract translation: 提供了用于分离生物样品中的蛋白质混合物的方法和试剂盒。 还提供了通过分离方法和试剂盒检测和分析生物样品中蛋白质的方法。 这些方法在评估对心脏和骨骼肌细胞的细胞的损伤以及通过检测受试者的血清中的肌丝蛋白质的早期心肌损伤的临床诊断中特别有用。

    SCREENING FOR NEUROTOXIC AMINO ACID ASSOCIATED WITH NEUROLOGICAL DISORDERS
    10.
    发明申请
    SCREENING FOR NEUROTOXIC AMINO ACID ASSOCIATED WITH NEUROLOGICAL DISORDERS 失效
    筛选与神经病变相关的神经毒性氨基酸

    公开(公告)号：US20070254315A1

    公开(公告)日：2007-11-01

    申请号：US11760668

    申请日：2007-06-08

    Applicant: Paul Cox ,  Sandra Banack ,  Susan Murch

    Inventor： Paul Cox ,  Sandra Banack ,  Susan Murch

    IPC: G01N33/566 ,  G01N33/567

    CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

    Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

    Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定获得的组织样品中的β-N-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者的神经障碍或预测受试者发展神经障碍的可能性的方法 从主题。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

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