公开(公告)号：US07901895B2

公开(公告)日：2011-03-08

申请号：US11837899

申请日：2007-08-13

Applicant: Paul A Cox ,  Sandra Banack ,  Susan Murch

Inventor： Paul A Cox ,  Sandra Banack ,  Susan Murch

IPC: G01N33/48 ,  G01N33/02 ,  G01N33/18 ,  G01N33/53 ,  C12Q1/04

CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定组织样品中的B-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者神经障碍或预测受试者发展神经障碍的可能性的方法 从主题获得。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

公开(公告)号：US07670783B2

公开(公告)日：2010-03-02

申请号：US11760668

申请日：2007-06-08

Applicant: Paul A Cox ,  Sandra Banack ,  Susan Murch

Inventor： Paul A Cox ,  Sandra Banack ,  Susan Murch

IPC: G01N33/48 ,  G01N33/50

CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定组织样品中的B-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者神经障碍或预测受试者发展神经障碍的可能性的方法 从主题获得。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

公开(公告)号：US06512976B1

公开(公告)日：2003-01-28

申请号：US09844912

申请日：2001-04-27

Applicant: Anthony E. Sabatino ,  Leroy G. Romero ,  Michael D. Pyne ,  Steven D. Martinez ,  Paul A. Cox

Inventor： Anthony E. Sabatino ,  Leroy G. Romero ,  Michael D. Pyne ,  Steven D. Martinez ,  Paul A. Cox

IPC: G01C2126

CPC classification number: G01S13/86 ,  G01C21/005 ,  G01S5/0252

Abstract: A method and system for terrain aided navigation which provide more precise and more accurate position, velocity, altitude, and attitude for an air vehicle. The present method is a continuous, active, all-weather, day/night, self-contained vehicle system used for terminal and en route navigation. The present method utilizes on-vehicle sensing elements which require no external stimulation, eliminating dependence on external ground and space-based navigation aides. The present method also provides a drift-free solution. The present method is more difficult to detect (sense) and more difficult to disrupt.

Abstract translation: 一种用于地形辅助导航的方法和系统，为航空器提供更精确，更准确的位置，速度，高度和姿态。 目前的方法是一种连续，主动，全天候的昼/夜，独立车辆系统，用于航路和航路导航。 本方法利用不需要外部刺激的车载感测元件，消除对外部地面和基于天基的导航辅助设备的依赖。 本方法还提供了无漂移解决方案。 目前的方法更难以检测（感觉），更难以破坏。

公开(公告)号：US20110183424A1

公开(公告)日：2011-07-28

申请号：US13015288

申请日：2011-01-27

Applicant: Paul A. Cox ,  Sandra A. Banack ,  Susan J. Murch

Inventor： Paul A. Cox ,  Sandra A. Banack ,  Susan J. Murch

IPC: G01N33/48

CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定组织样品中的B-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者神经障碍或预测受试者发展神经障碍的可能性的方法 从主题获得。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

公开(公告)号：US07728727B2

公开(公告)日：2010-06-01

申请号：US11381808

申请日：2006-05-05

Applicant: Paul A Cox

Inventor： Paul A Cox

IPC: G08B13/14

CPC classification number: G06Q10/087 ,  G06Q10/08 ,  G06Q50/30

Abstract: A method of dynamically keeping inventory of items in a vehicle in transit is provided. The method includes detecting an event during transit and conducting interrogations of inventory based on the detected event. The method can compare these inventories to determine disposition of inventory items by location.

Abstract translation: 提供了一种在运输中动态保持车辆中物品库存的方法。 该方法包括在传输期间检测事件并且基于检测到的事件进行库存的询问。 该方法可以比较这些库存，以确定库存物品的位置。

公开(公告)号：US07256002B2

公开(公告)日：2007-08-14

申请号：US10731411

申请日：2003-12-08

Applicant: Paul A Cox ,  Sandra A Banack ,  Susan Murch

Inventor： Paul A Cox ,  Sandra A Banack ,  Susan Murch

IPC: G01N33/50

CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定获得的组织样品中的β-N-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者的神经障碍或预测受试者发展神经障碍的可能性的方法 从主题。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

公开(公告)号：US5599839A

公开(公告)日：1997-02-04

申请号：US424558

申请日：1995-04-17

Applicant: Michael R. Boyd ,  Paul A. Cox ,  Gordon M. Cragg ,  Peter M. Blumberg ,  Nancy A. Sharkey ,  Junichi Ishitoya ,  James B. McMahon ,  John A. Beutler ,  Owen S. Weislow ,  John H. Cardellina, II ,  Krik R. Gustafson

Inventor： Michael R. Boyd ,  Paul A. Cox ,  Gordon M. Cragg ,  Peter M. Blumberg ,  Nancy A. Sharkey ,  Junichi Ishitoya ,  James B. McMahon ,  John A. Beutler ,  Owen S. Weislow ,  John H. Cardellina, II ,  Krik R. Gustafson

IPC: A61K31/22 ,  A61K36/18 ,  A61P31/12

CPC classification number: A61K31/22

Abstract: The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.

Abstract translation: 本发明涉及抗病毒组合物和治疗病毒感染患者的方法。 本发明的抗病毒组合物包含前列腺素，佛波酯衍生物和药学上可接受的载体。 具有抗病毒活性的本发明组合物不具有显着的肿瘤促进活性，并且不具有阻止其用于抗病毒治疗的其它实质性不利的毒理学性质。