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公开(公告)号：US09821045B2
公开(公告)日：2017-11-21
申请号：US15135216
申请日：2016-04-21
IPC分类号： A61K39/00 , A61K38/19 , A61K39/395 , A61K45/00 , A61K31/7088 , A61K45/06 , A61K39/39 , A61K31/4745 , A61K31/708
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/708 , A61K31/7088 , A61K38/193 , A61K39/39 , A61K45/06 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/6093
摘要： The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
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公开(公告)号：US20170182138A1
公开(公告)日：2017-06-29
申请号：US15345131
申请日：2016-11-07
发明人： Jaeyun Kim , David J. Mooney , Weiwei Aileen Li , Praveen Arany , Or Gadish
CPC分类号： A61K39/0011 , A61K38/193 , A61K41/0052 , A61K45/06 , A61K2039/5152 , A61K2039/5154 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/70 , B82Y5/00
摘要： The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
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公开(公告)号：US20160354520A1
公开(公告)日：2016-12-08
申请号：US15172549
申请日：2016-06-03
发明人： Jeong-Yun Sun , Xuanhe Zhao , Widusha R.K. Illeperuma , Kyu H. Oh , Joost J. Vlassak , Zhigang Suo , Jianyu Li , David J. Mooney
CPC分类号： A61L27/52 , A61L27/16 , A61L27/20 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/60 , C08J3/075 , C08J3/246 , C08J2333/26 , C08J2405/04 , C08L5/04 , C08L33/26 , C08L71/02 , C08L2201/54 , C08L2203/02 , C08L2205/04
摘要： The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
摘要翻译： 本发明的特征在于包含包含第一网络和第二网络的自愈互穿网络水凝胶的组合物。 第一网络包括共价交联，第二网络包括离子或物理交联。 例如，第一网络包括聚丙烯酰胺聚合物，第二网络包括藻酸盐聚合物。
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公开(公告)号：US09446107B2
公开(公告)日：2016-09-20
申请号：US14750423
申请日：2015-06-25
发明人： David J. Mooney , Omar Abdel-Rahman Ali , Eduardo Alexandre Barros E Silva , Hyun Joon Kong , Elliot Earl Hill, Jr. , Tanyarut Boontheekul
IPC分类号： A61K39/00 , A61L27/56 , A61L27/18 , A61K38/19 , A61L27/58 , A61L27/54 , A61L27/36 , A61L27/38
CPC分类号： A61K39/0011 , A61K9/0024 , A61K9/1647 , A61K38/1866 , A61K38/193 , A61K38/39 , A61K39/21 , A61K39/39 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55583 , A61K2039/6093 , A61L27/18 , A61L27/20 , A61L27/3633 , A61L27/38 , A61L27/3826 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/232 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/438 , A61L2300/604 , A61L2300/606 , A61L2400/18 , A61L2430/30 , A61L2430/34 , B33Y80/00 , C12N7/00 , C12N15/117 , C12N2310/17 , C12N2320/32 , C12N2740/16034 , Y02A50/411
摘要： A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
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公开(公告)号：US20160220668A1
公开(公告)日：2016-08-04
申请号：US15135294
申请日：2016-04-21
CPC分类号： A61K39/0011 , A61K31/4745 , A61K31/708 , A61K31/7088 , A61K38/193 , A61K39/39 , A61K45/06 , A61K2039/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/6093
摘要： The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
摘要翻译： 本发明包括用于在聚合物支架内产生感染模拟环境以刺激抗原特异性树突细胞活化的组合物，方法和装置。 本发明的装置用于为受试者提供针对感染和癌症的保护性免疫。
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公开(公告)号：US09381235B2
公开(公告)日：2016-07-05
申请号：US14185494
申请日：2014-02-20
IPC分类号： A61K39/00 , A61K39/35 , A61K39/39 , A61K39/102
CPC分类号： A61K39/0008 , A61K39/0011 , A61K39/102 , A61K39/35 , A61K39/39 , A61K2039/5158 , A61K2039/55522 , A61K2039/55561 , A61K2039/577 , A61K2039/70
摘要： Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
摘要翻译： 生物材料系统，例如凝胶支架，用于体内募集免疫细胞并促进其向非炎症表型的活化，从而导致炎症的抑制。 组合物和方法可用于降低自身免疫，慢性炎症，过敏和牙周病的严重性。
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公开(公告)号：US20160058903A1
公开(公告)日：2016-03-03
申请号：US14783559
申请日：2014-04-11
发明人： Cathal J. Kearney , Uyanga Tsedev , David J. Mooney , Aristidis Veves , Thomas Michael Braschler , Sidi A. Bencherif
CPC分类号： A61L15/28 , A61K38/046 , A61L15/425 , A61L15/44 , A61L2300/412 , C08L5/04
摘要： The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
摘要翻译： 本发明提供了与常规藻酸盐敷料相关的缺点的解决方案。 本发明的特征在于改进的藻酸盐敷料或绷带以及导致预加载药物的藻酸盐片材的制造方法，可以以冻干状态储存，并且在给药时可以使用。
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公开(公告)号：US20150359928A1
公开(公告)日：2015-12-17
申请号：US14738294
申请日：2015-06-12
发明人： Luo Gu , Ovijit Chaudhuri , Nathaniel D. Huebsch , David J. Mooney , Max Carlton Darnell , Simon Young
CPC分类号： A61L27/20 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2400/12 , A61L2430/02 , C12N5/0654 , C12N2506/1346 , C12N2513/00 , C12N2533/74 , C08L5/04
摘要： Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
摘要翻译： 提供了可用于调节细胞行为和增强组织再生（例如骨再生）的快速松弛水凝胶。
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公开(公告)号：US20150065685A1
公开(公告)日：2015-03-05
申请号：US14389136
申请日：2013-03-12
发明人： Praveen R. Arany , David J. Mooney
CPC分类号： A61K41/0042 , A61K38/00 , A61K38/1841 , A61K47/643 , A61K47/6929
摘要： The invention provides compositions and methods for laser actuated drug delivery. Compositions comprise serum albumin based particles conjugated with therapeutic agents which cab become bioavailable upon actuation of the particles by light, e.g. low power laser.
摘要翻译： 本发明提供了用于激光致动药物递送的组合物和方法。 组合物包含与治疗剂缀合的血清白蛋白基颗粒，驾驶室在通过光引发颗粒时变得具有生物利用度。 低功率激光
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