公开(公告)号：US20160287728A1

公开(公告)日：2016-10-06

申请号：US15153411

申请日：2016-05-12

申请人： STC.UNM

发明人： Jeffrey P. Norenberg

IPC分类号： A61K51/04

CPC分类号： A61K51/0453 ,  A61K31/4178 ,  A61K51/00 ,  A61K51/044 ,  A61K51/0497 ,  G01N33/569 ,  G01N2333/70525 ,  G01N2333/70553 ,  Y02A50/47 ,  Y02A50/481

摘要： The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.

摘要翻译： 本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。 本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。 该新型成像探针能够检测感染的细胞以及组织。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 这种新型探针也可用于监测患者对治疗这些疾病状态或病症治疗中使用的治疗性治疗和其他干预措施或疗法的反应。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。 还描述了药物组合物。

公开(公告)号：US09453253B2

公开(公告)日：2016-09-27

申请号：US14404134

申请日：2013-03-07

申请人： STC.UNM ,  THE JOHNS HOPKINS UNIVERSITY

发明人： Graham Timmins ,  Seong Choi ,  Zachary Sharp ,  Viorel Atudorei ,  Mamoudou Maiga ,  William Bishai

IPC分类号： G01N33/60 ,  C12Q1/04 ,  G01N33/569 ,  C12Q1/28

CPC分类号： C12Q1/04 ,  C12Q1/28 ,  C12Q2304/48 ,  G01N33/5695 ,  G01N33/60 ,  G01N2333/35

摘要： The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopically labeled isoniazid.

摘要翻译： 本发明涉及通过在施用同位素标记的异烟肼之后测量呼出的，同位素标记的氮气来诊断患者中细菌感染的存在或不存在，特别是结核病感染的方法。

公开(公告)号：US20160208238A1

公开(公告)日：2016-07-21

申请号：US14996048

申请日：2016-01-14

申请人： Sandia Corporation ,  STC.UNM

发明人： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC分类号： C12N11/14

CPC分类号： G01N1/2806 ,  C08K3/36 ,  C12N11/14 ,  G01N1/2853

摘要： The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

摘要翻译： 本发明涉及使用硅酸将生物材料（包括细胞结构）转化为无机材料以提供具有稳定结构和功能的生物复合材料（纳米材料）。 在本发明中，已经发现了稳定生物材料的结构和功能的手段，包括细胞，生物分子，肽，蛋白质（特别是酶），脂质，脂质囊泡，多糖，细胞骨架细丝，组织和器官与硅 酸，使得这些材料可以用作生物复合材料。 在许多情况下，这些材料保留其原始生物活性，并且可以在恶劣条件下使用，否则会破坏生物材料的完整性。 在某些情况下，这些生物材料可能长时间保持稳定，并在储存后重构，以将生物材料返回其原始形式。 此外，通过暴露整个细胞以形成CSCs，CSC可以起到提供独特的系统来研究否则不可用的酶或级联的酶。

公开(公告)号：US20160193161A1

公开(公告)日：2016-07-07

申请号：US14911943

申请日：2014-08-14

申请人： STC.UNM

发明人： Jeff Wade HILL

IPC分类号： A61K31/138 ,  A61K31/325 ,  A61K45/06 ,  A61K9/00

CPC分类号： A61K31/138 ,  A61K9/0019 ,  A61K31/27 ,  A61K31/325 ,  A61K45/06 ,  G01N33/5058 ,  A61K2300/00

摘要： Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

摘要翻译： 使用高通量筛选，在氧 - 葡萄糖剥夺（OGD）模型中，将isoxsuprine盐酸盐鉴定为有效的神经保护性化合物。 在短暂性局灶性缺血的动物中动脉闭塞（MCAO）模型中，与载体相比，isoxsuprine显着降低了梗死体积。 因此，本发明提供了治疗和药物组合物的方法，其可用于治疗和预防各种与缺血相关的损伤，包括中风。

公开(公告)号：US20150320681A1

公开(公告)日：2015-11-12

申请号：US14797487

申请日：2015-07-13

申请人： STC.UNM ,  SANDIA CORPORATION

发明人： C. Jeffrey Brinker ,  Carlee Erin Ashley ,  Xingmao Jiang ,  Juewen Liu ,  David S. Peabody ,  Walker Richard Wharton ,  Eric Carnes ,  Bryce Chackerian ,  Cheryl L. Willman

IPC分类号： A61K9/127 ,  A61K33/24 ,  A61K31/704 ,  A61K31/513 ,  A61K49/00 ,  A61K31/575

CPC分类号： A61K9/127 ,  A61K9/1277 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/513 ,  A61K31/575 ,  A61K31/704 ,  A61K33/24 ,  A61K49/005

摘要： Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

公开(公告)号：US09173692B1

公开(公告)日：2015-11-03

申请号：US13918949

申请日：2013-06-15

申请人： STC.UNM

发明人： Paul E. Kaloostian

IPC分类号： A61B17/86 ,  A61B17/00 ,  A61B17/68

CPC分类号： A61B17/864 ,  A61B17/68 ,  A61B17/7002 ,  A61B17/702 ,  A61B17/7035 ,  A61B17/7037 ,  A61B17/7098 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/8615 ,  A61B17/8625 ,  A61B17/866 ,  A61B17/8685 ,  A61B17/8841 ,  A61B2017/00933 ,  A61B2017/00964 ,  A61F2/44 ,  A61F2002/2835 ,  A61F2002/30405 ,  A61F2002/3055 ,  A61F2002/30601 ,  A61F2002/30784 ,  A61F2002/30787 ,  A61F2310/00023 ,  A61F2310/00359 ,  A61F2310/00958 ,  A61F2310/0097

摘要： Composite orthopedic devices that facilitate spine stabilization, such as: bone screws, rods, plates, interbodies, and corpectomy cages are disclosed. They are designed to provide both strength and load carrying capabilities, while increasing bio-integration of the devices with the surrounding bone tissue. They are constructed of composite layers of allograft and/or autograft bone and a structural material, such as titanium alloy or carbon/graphite fiber composite. Cannulations within the device are loaded with a mixture of stem cells, particles of allograft and/or autograft bone, and bone growth factors, such as BMP-2. The cannulations are connected to the surface of the device via multiple fenestrations that provide pathways to supply the bone/stem cell mixture to the surface, allowing living bone tissue to grow and insure bio-integration. The devices can also have radiofrequency (RF) stimulation implantation within the structure of the implanted device, capable of responding to external RF stimulation of enhanced bone growth.

摘要翻译： 公开了促进脊柱稳定的复合矫形装置，例如：骨螺钉，杆，板，中间体和椎骨切除术笼。 它们旨在提供强度和负载能力，同时增加设备与周围骨组织的生物整合。 它们由同种异体移植物和/或自体骨的复合层和诸如钛合金或碳/石墨纤维复合材料的结构材料构成。 装置内的装置装载有干细胞，同种异体移植物和/或自体骨的颗粒和骨生长因子如BMP-2的混合物。 插管通过多个窗口连接到装置的表面，这些开窗提供将骨/干细胞混合物提供给表面的途径，允许活骨组织生长并确保生物整合。 该装置还可以在植入装置的结构内具有射频（RF）刺激植入，能够响应增强的骨生长的外部RF刺激。

公开(公告)号：US09142400B1

公开(公告)日：2015-09-22

申请号：US13944808

申请日：2013-07-17

申请人： STC.UNM

发明人： Steven R. J. Brueck ,  Stephen D. Hersee ,  Seung-Chang Lee ,  Daniel Feezell

IPC分类号： H01L29/06 ,  H01L21/02 ,  H01L27/12

CPC分类号： H01L21/02107 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/02532 ,  H01L21/02538 ,  H01L21/02639 ,  H01L27/1211 ,  H01L29/045 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/66469 ,  H01L29/66795 ,  H01L29/775 ,  H01L29/7783 ,  H01L29/785

摘要： A method for making a heteroepitaxial layer. The method comprises providing a semiconductor substrate. A seed area delineated with a selective growth mask is formed on the semiconductor substrate. The seed area comprises a first material and has a linear surface dimension of less than 100 nm. A heteroepitaxial layer is grown on the seed area, the heteroepitaxial layer comprising a second material that is different from the first material. Devices made by the method are also disclosed.

摘要翻译： 一种制造异质外延层的方法。 该方法包括提供半导体衬底。 在半导体衬底上形成用选择性生长掩模描绘的种子区域。 种子区域包括第一材料并且具有小于100nm的线性表面尺寸。 在种子区域上生长异质外延层，异质外延层包含不同于第一材料的第二材料。 还公开了通过该方法制造的器件。

公开(公告)号：US09132120B1

公开(公告)日：2015-09-15

申请号：US13783785

申请日：2013-03-04

申请人： STC.UNM ,  University of Maryland, Baltimore

发明人： Alan Edward Tomkinson ,  Feyruz Rassool

IPC分类号： A61K31/4184 ,  C40B40/06 ,  A61K31/165

CPC分类号： A61K31/4184 ,  A61K31/00 ,  A61K31/165 ,  A61K45/06 ,  C12Q1/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57434 ,  G06F19/00 ,  G06F19/20 ,  G06F19/3456 ,  Y02A90/26 ,  A61K2300/00

摘要： In one embodiment, the invention provides a method of treating a subject suffering from a breast cancer tumor which is non-responsive or intrinsically resistant to anti-estrogen therapy comprising administering a therapeutically effective amount of an inhibitor of alternative (ALT) non-homologous end joining (NHEJ) factor to the subject.In another embodiment the invention provides a method of treating a subject who suffers from a pancreatic cancer which is non-responsive to chemotherapy and/or radiation comprising co-administering a therapeutically effective amount of PARP1 inhibitor and a DNA ligase IIIα inhibitor to the subject. Related diagnostic methods, nucleic acid arrays, devices and kits are also provided.

摘要翻译： 在一个实施方案中，本发明提供了治疗患有对抗雌激素疗法无反应或本质上抗性的乳腺癌肿瘤的受试者的方法，其包括施用治疗有效量的替代（ALT）非同源末端的抑制剂 加入（NHEJ）因素。 在另一个实施方案中，本发明提供了治疗患有对化学疗法和/或放射线无反应的胰腺癌的受试者的方法，包括向受试者共同施用治疗有效量的PARP1抑制剂和DNA连接酶IIIα抑制剂。 还提供了相关的诊断方法，核酸阵列，装置和试剂盒。

公开(公告)号：US20150250808A1

公开(公告)日：2015-09-10

申请号：US14434931

申请日：2013-10-15

申请人： Vojo P. DERETIC ,  Eliseo F. CASTILLO ,  STC.UNM

发明人： Vojo P. Deretic ,  Eliseo F. Castillo

IPC分类号： A61K31/704 ,  A61K31/4184 ,  A61K31/473 ,  A61K31/495 ,  A61K31/4365 ,  A61K31/472 ,  A61K31/4535 ,  A61K31/65 ,  A61K31/4453 ,  A61K31/5415 ,  A61K31/277 ,  A61K31/38 ,  A61K31/475 ,  A61K31/57 ,  A61K38/17 ,  C07K16/28 ,  A61K31/381 ,  A61K31/436 ,  A61K31/506 ,  C07K16/24 ,  G01N33/68 ,  G01N33/569 ,  A61K45/06

CPC分类号： A61K31/704 ,  A61K9/0073 ,  A61K31/00 ,  A61K31/277 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4453 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/475 ,  A61K31/495 ,  A61K31/506 ,  A61K31/5415 ,  A61K31/57 ,  A61K31/65 ,  A61K31/713 ,  A61K38/00 ,  A61K38/177 ,  A61K38/1793 ,  A61K45/06 ,  C07K16/245 ,  C07K16/28 ,  C07K2317/76 ,  G01N33/5055 ,  G01N33/5695 ,  G01N33/6842 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2333/4719 ,  G01N2333/4724 ,  G01N2333/54 ,  G01N2333/545 ,  G01N2333/90212 ,  G01N2500/02 ,  G01N2500/20

摘要： In one embodiment, the invention provides a method of treating a subject suffering from a Mycobacterium infection by administering to the subject a therapeutically-effective amount of a degradative autophagy agonist or a secretory autophagy antagonist. In another embodiment, the invention provides a method of treating a subject suffering from one or more diseases selected from the group consisting of a Mycobacterium infection, an inflammatory disorder, an immune disorder, a cancer and a neurodegenerative disorder by administering to the subject a therapeutically-effective amount of a TBK-1 antagonist (e.g. BX795 or amlexanox). Related pharmaceutical compositions, diagnostic and screening assays and kits are also provided.

摘要翻译： 在一个实施方案中，本发明提供了通过向受试者施用治疗有效量的降解性自噬激动剂或分泌型自噬拮抗剂来治疗患有分枝杆菌感染的受试者的方法。 在另一个实施方案中，本发明提供了一种治疗患有一种或多种疾病的受试者的治疗方法，所述疾病选自由分枝杆菌感染，炎症性疾病，免疫病症，癌症和神经变性疾病组成的组， - 有效量的TBK-1拮抗剂（如BX795或amlexanox）。 还提供了相关的药物组合物，诊断和筛选测定和试剂盒。

公开(公告)号：US20150239952A1

公开(公告)日：2015-08-27

申请号：US14629791

申请日：2015-02-24

申请人： STC.UNM

发明人： Yubin Miao ,  Haixun Guo

IPC分类号： C07K14/68 ,  A61K51/08

CPC分类号： C07K14/68 ,  A61K38/00 ,  A61K45/06 ,  A61K51/08 ,  A61K51/086 ,  A61K51/088 ,  C07K7/54

摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.