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公开(公告)号：US20180235597A1
公开(公告)日：2018-08-23
申请号：US15957301
申请日：2018-04-19
发明人： Karen S. Troxel , Kevin T. Stone
CPC分类号： A61B17/0401 , A61B17/04 , A61B2017/0445 , A61L31/04 , A61L31/042 , A61L31/044 , A61L31/045 , A61L31/046 , A61L31/047 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/112 , A61L2300/214 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2430/02
摘要： A flexible anchor for coupling a suture to a bone is provided. The anchor is composed of non-woven electrospun fibers and has an elongate tubular body that extends from a first end to a second end. The anchor is configured to receive a suture that enters the anchor through a first aperture and exits the anchor through a second aperture. When free ends of the suture are pulled, the anchor transitions from a first configuration to a second anchoring configuration.
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公开(公告)号：US09974534B2
公开(公告)日：2018-05-22
申请号：US14675082
申请日：2015-03-31
发明人： Karen S. Troxel , Kevin T. Stone
CPC分类号： A61B17/0401 , A61B17/04 , A61B2017/0445 , A61L31/04 , A61L31/042 , A61L31/044 , A61L31/045 , A61L31/046 , A61L31/047 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/112 , A61L2300/214 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2430/02
摘要： A flexible anchor for coupling a suture to a bone is provided. The anchor is composed of non-woven electrospun fibers and has an elongate tubular body that extends from a first end to a second end. The anchor is configured to receive a suture that enters the anchor through a first aperture and exits the anchor through a second aperture. When free ends of the suture are pulled, the anchor transitions from a first configuration to a second anchoring configuration.
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公开(公告)号：US20180049744A1
公开(公告)日：2018-02-22
申请号：US15726662
申请日：2017-10-06
申请人： P Tech, LLC
发明人： Peter M. Bonutti
IPC分类号： A61B17/12 , A61L31/04 , A61L27/52 , A61L27/22 , A61K38/48 , A61K35/24 , A61K31/715 , A61K31/215
CPC分类号： A61B17/12 , A61B17/12136 , A61B17/1325 , A61B17/135 , A61B17/70 , A61B17/72 , A61B17/8847 , A61B18/14 , A61B2017/005 , A61B2017/00893 , A61B2017/12004 , A61B2018/00011 , A61B2018/00023 , A61B2018/0022 , A61F2/38 , A61F2/44 , A61K31/215 , A61K31/715 , A61K35/24 , A61K38/4833 , A61L27/222 , A61L27/52 , A61L31/045 , A61L31/145 , A61L2400/04
摘要： The present disclosure provides a method of positioning a medical device in a patient. The method includes coating a balloon with a substance, wherein the coating substance comprises at least one layer comprised at least partially of a medicinal agent and a polymer, inserting the deflated balloon into a cardiac system of the patient, placing the balloon in the proper location in the cardiac system of the patient, and inflating the balloon by injecting a sterile liquid from a syringe into the balloon. The method also includes positioning the substance proximate the tissue of the cardiac system of the patient, wherein the cardiovascular drug medicinal agent comprising the substance is drug eluting.
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公开(公告)号：US20180049743A1
公开(公告)日：2018-02-22
申请号：US15726599
申请日：2017-10-06
申请人： P Tech, LLC
发明人： Peter M. Bonutti
IPC分类号： A61B17/12 , A61L31/04 , A61L27/52 , A61L27/22 , A61K38/48 , A61K35/24 , A61K31/715 , A61K31/215
CPC分类号： A61B17/12 , A61B17/12136 , A61B17/1325 , A61B17/135 , A61B17/70 , A61B17/72 , A61B17/8847 , A61B18/14 , A61B2017/005 , A61B2017/00893 , A61B2017/12004 , A61B2018/00011 , A61B2018/00023 , A61B2018/0022 , A61F2/38 , A61F2/44 , A61K31/215 , A61K31/715 , A61K35/24 , A61K38/4833 , A61L27/222 , A61L27/52 , A61L31/045 , A61L31/145 , A61L2400/04
摘要： The present disclosure provides a system for injecting a drug eluting construct in a patient. The construct includes multiple cellular based microcaspules, wherein the multiple cellular based microcapsules create at least one of a plurality of layers or sections of microcapsules joined together to comprise an implant. There is a medicinal agent within the microcapsules. A syringe and needle inject the implant constructed of microcapsules into the patient at least one of during and after a surgical procedure. The medicinal agent controllably releases into the patient both immediately and at a delayed time.
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公开(公告)号：US09687501B2
公开(公告)日：2017-06-27
申请号：US13894396
申请日：2013-05-14
申请人： Xin Ji , Cheng Xing , Xueshen Shi , Jianping Chen
发明人： Xin Ji , Cheng Xing , Xueshen Shi , Jianping Chen
IPC分类号： A61K31/718 , A61L24/00 , A61L26/00 , A61K9/14 , C08L3/18 , C08L3/04 , C08L89/06 , C08B31/12 , C08B31/08 , C08B31/02 , C08B33/04 , C08B31/10 , C08B31/16 , C08B35/02 , C08B33/06 , C08B35/06 , C08B35/04 , C08B33/02 , C08B31/04 , C08B30/20 , C08B31/00 , C08B30/00 , A61K31/738 , A61L24/08 , A61K45/06 , A61K9/19 , C08B31/06 , A61K9/00
CPC分类号： A61L31/042 , A61K9/0014 , A61K9/14 , A61K9/19 , A61K31/718 , A61K31/738 , A61K45/06 , A61L24/0015 , A61L24/0036 , A61L24/0073 , A61L24/08 , A61L24/104 , A61L26/0023 , A61L26/0085 , A61L31/045 , A61L31/125 , A61L2300/406 , A61L2400/04 , A61L2430/34 , C08B30/00 , C08B30/20 , C08B31/00 , C08B31/003 , C08B31/02 , C08B31/04 , C08B31/08 , C08B31/10 , C08B31/12 , C08B31/16 , C08B33/02 , C08B33/04 , C08B33/06 , C08B35/02 , C08B35/04 , C08B35/06 , C08L3/04 , C08L3/18 , C08L89/06 , Y10T428/2982
摘要： A modified starch material is arranged for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
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公开(公告)号：US20160287242A1
公开(公告)日：2016-10-06
申请号：US14675082
申请日：2015-03-31
发明人： Karen S. TROXEL , Kevin T. Stone
CPC分类号： A61B17/0401 , A61B17/04 , A61B2017/0445 , A61L31/04 , A61L31/042 , A61L31/044 , A61L31/045 , A61L31/046 , A61L31/047 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/112 , A61L2300/214 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2430/02
摘要： A flexible anchor for coupling a suture to a bone is provided. The anchor is composed of non-woven electrospun fibers and has an elongate tubular body that extends from a first end to a second end. The anchor is configured to receive a suture that enters the anchor through a first aperture and exits the anchor through a second aperture. When free ends of the suture are pulled, the anchor transitions from a first configuration to a second anchoring configuration
摘要翻译： 提供了一种用于将缝合线耦合到骨骼的柔性锚固件。 锚固体由无纺电纺纤维组成，并具有从第一端延伸到第二端的细长管状体。 锚固件被构造成接收通过第一孔进入锚固件的缝合线，并通过第二孔离开锚固件。 当缝合线的自由端被拉动时，锚从第一构型转变到第二锚定构型
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57.发明申请Methods And Compositions For Medical Articles Produced From Proteinaceous Compounds 审中-公开用于蛋白质化合物生产的医疗用品的方法和组成公开(公告)号：US20150359926A1
公开(公告)日：2015-12-17
申请号：US14307129
申请日：2014-06-17
申请人： Curtis E. Jones , John P. Kennedy
发明人： Curtis E. Jones , John P. Kennedy
CPC分类号： C12N9/6424 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/425 , A61L15/44 , A61L24/0015 , A61L24/0036 , A61L24/043 , A61L24/104 , A61L24/108 , A61L31/041 , A61L31/045 , A61L31/047 , A61L31/146 , A61L31/16 , A61L2300/404 , A61L2400/04 , C08L89/06
摘要： The invention disclosed herein provides compositions and methods for biocompatible biomaterials with improved control of microorganisms, improved biocompatibility, lower toxicity, and reduce vCJD transmission potential. These combined benefits cascade to provide improved efficacy, improved patient compliance and improved performance, while limiting clinical complications in treatment.
摘要翻译： 本文公开的本发明提供了具有改进的微生物控制，改善的生物相容性，较低毒性和降低vCJD传播潜能的生物相容性生物材料的组合物和方法。 这些联合益处级联以提供改善的功效，改善患者依从性和改善的性能，同时限制治疗中的临床并发症。
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58.发明授权公开(公告)号：US09017398B2
公开(公告)日：2015-04-28
申请号：US13177865
申请日：2011-07-07
申请人： Bjoern Klocke , Claus Harder , Alexander Borck
发明人： Bjoern Klocke , Claus Harder , Alexander Borck
CPC分类号： A61L31/16 , A61L31/022 , A61L31/045 , A61L31/10 , A61L31/148 , A61L2420/08
摘要： A drug-eluting stent, comprising a base body that is made of an implant material, the base body being partially or entirely covered on the abluminal side with an active ingredient-releasing coating that comprises or is made of a polymer and an active ingredient having an antiproliferative effect, characterized in that the stent's luminal surface and the abluminal surface carrying the active ingredient-releasing coating are covered by a biocorrodible protective layer in a form-fitting manner.
摘要翻译： 一种药物洗脱支架，其包括由植入物材料制成的基体，所述基体部分地或完全地覆盖在所述外侧面上，所述活性成分释放涂层包含聚合物或由聚合物制成的活性成分和活性成分，所述活性成分具有 抗增殖作用，其特征在于支架的腔表面和携带有效成分释放的涂层的囊膜表面以形状配合的方式被生物防腐保护层覆盖。
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公开(公告)号：US08603511B2
公开(公告)日：2013-12-10
申请号：US13744949
申请日：2013-01-18
CPC分类号： A61K9/06 , A61K38/4833 , A61K47/42 , A61L24/0015 , A61L24/0031 , A61L24/102 , A61L27/222 , A61L27/52 , A61L27/54 , A61L31/045 , A61L31/145 , A61L31/16 , A61L2300/254 , A61L2300/418 , A61L2400/06 , A61L2430/02 , A61L2430/34
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US08575132B2
公开(公告)日：2013-11-05
申请号：US13740033
申请日：2013-01-11
申请人： Xin Ji
发明人： Xin Ji , Cheng Xing , Xueshen Shi
IPC分类号： A61K31/718 , A61F13/02 , A61F13/53
CPC分类号： A61L31/042 , A61K9/0014 , A61K9/14 , A61K9/19 , A61K31/718 , A61K31/738 , A61K45/06 , A61L24/0015 , A61L24/0036 , A61L24/0073 , A61L24/08 , A61L24/104 , A61L26/0023 , A61L26/0085 , A61L31/045 , A61L31/125 , A61L2300/406 , A61L2400/04 , A61L2430/34 , C08B30/00 , C08B30/20 , C08B31/00 , C08B31/003 , C08B31/02 , C08B31/04 , C08B31/08 , C08B31/10 , C08B31/12 , C08B31/16 , C08B33/02 , C08B33/04 , C08B33/06 , C08B35/02 , C08B35/04 , C08B35/06 , C08L3/04 , C08L3/18 , C08L89/06 , Y10T428/2982
摘要： A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
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