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    Hydroporphyrins for photoacoustic imaging
    53.
    发明授权
    Hydroporphyrins for photoacoustic imaging 有权

    公开(公告)号：US12042548B2

    公开(公告)日：2024-07-23

    申请号：US16483394

    申请日：2018-02-02

    Applicant: NIRvana Sciences Inc.

    Inventor： James Bruce Pitner ,  Rajalekha Manjakuppam Rajamahendiran ,  Russell D. Thomas

    IPC: A61K49/22

    CPC classification number: A61K49/221 ,  A61K49/227

    Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a bacteriochlorin, a metallobacteriochlorin, a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed bacteriochlorins, metallobacteriochlorins, and/or derivatives thereof simultaneously.

    Method and apparatus for ultrasonic delivery of drugs and contrast agents
    56.
    发明授权
    Method and apparatus for ultrasonic delivery of drugs and contrast agents 有权

    公开(公告)号：US11850096B1

    公开(公告)日：2023-12-26

    申请号：US13037996

    申请日：2011-03-01

    Applicant: Cetin Cetinkaya

    Inventor： Cetin Cetinkaya

    IPC: A61B8/08 ,  A61K49/22 ,  A61K38/17 ,  A61K47/69 ,  A61N7/00

    CPC classification number: A61B8/481 ,  A61B8/52 ,  A61B8/5223 ,  A61B8/5292 ,  A61K38/177 ,  A61K38/178 ,  A61K47/6925 ,  A61K49/22 ,  A61K49/221 ,  A61K49/222 ,  A61K49/223 ,  A61K49/227 ,  A61N2007/0004 ,  A61N2007/0039

    Abstract: A method, device and system for ultrasonic delivery and attachment of ligand-receptor based drugs and/or drug carriers and/or image enhancing contrast agents utilizing catch and slip bond mechanisms in a targeted part(s) of the human or animal (patient) body or organs or tissue is described and disclosed. The system includes an acoustic power source coupled to an acoustic transducer with the acoustic transducer placed upon a patient's delivery zone. The acoustic transducer transmits an acoustic field to the target drug delivery and/or imaging zone. A detection probe and/or a probe of an imaging system are placed over or within said delivery zone and the probe is coupled to a sensing/imaging system. A control computer that controls power and wave shape of the acoustic signal generated into the acoustic filed by the acoustic power source and receives data from the sensing/imaging system. This system utilizes catch and slip bonds for the delivery of drugs and/or drug carriers and/or image enhancing contrast agents. Placing an acoustic transducer over a delivery zone having ligand-receptor based drugs and/or drug carriers and/or image enhancing contrast agents. The method includes coupling an acoustic power source to said acoustic power source and installing a probe within or over said delivery zone. The probe is coupled to a sensing/imaging system. A control computer is used to control a power and a wave shape of the acoustic field generated by said acoustic transducer. The method uses a catch and slip bonds within said acoustic field to deliver ligand-receptor based drugs and/or drug carriers and/or image enhancing contrast.

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