公开(公告)号：US20240302266A1

公开(公告)日：2024-09-12

申请号：US18548283

申请日：2022-03-04

Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.

Inventor： Thorsten GRAUNKE ,  Wladimir TSCHEKALINSKIJ ,  Stephan JUNGER ,  Jens-Uwe GARBAS

IPC: G01N21/25 ,  G01N21/17 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/3577

CPC classification number: G01N21/255 ,  G01N21/1702 ,  G01N21/3504 ,  G01N2021/1704 ,  G01N2021/3133 ,  G01N21/3577 ,  G01N2201/0675

Abstract: The invention relates to an assembly for a multispectral light emission, comprising at least one wide-band light source (1), a filter array (4) of multiple spectral filters, and an optical switch device (2) for controlling the passage of the light emitted from the light source (1) through the filter array (4). In one embodiment, the optical switch device (2) is made of an array of micromirrors (16) or micro-diaphragms and is designed and arranged such that the optical switch can guide light emitted from the light source (1) only through one or more arbitrarily specifiable spectral filters of the filter array (4) in a controlled manner. The invention also relates to a multispectral sensor comprising such an assembly for a multispectral light emission. The assembly allows a multispectral sensor to be provided inexpensively in a miniaturized design with a plurality of spectral channels.

公开(公告)号：US12072241B2

公开(公告)日：2024-08-27

申请号：US17180109

申请日：2021-02-19

Applicant: Texas Instruments Incorporated

Inventor： Philip Scott King

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/28 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/10 ,  G01J2003/2866 ,  G01N2201/0675

Abstract: In described examples, a spatial light modulator includes groups of pixels. Each group is arranged to transmit only a respective portion of a light spectrum. The respective portion has a respective dominant color. The respective portions of the light spectrum are distinct from one another, according to their respective dominant colors. Each group is controlled by a respective reset signal. The spatial light modulator is coupled to receive a selection from the integrated circuit and in response to the selection: cause a selected one of the groups to transmit its respective portion of the light spectrum; and cause an unselected one of the groups to block transmission of its respective portion of the light spectrum. A photodetector is coupled to: receive the respective portion of the light spectrum transmitted by the selected group; and output a signal indicating an intensity thereof.

公开(公告)号：US20240241057A1

公开(公告)日：2024-07-18

申请号：US18563631

申请日：2022-05-23

Applicant: NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Zhiwei HUANG ,  Li GONG ,  Shulang LIN

IPC: G01N21/65 ,  G01N21/47 ,  G02B21/33

CPC classification number: G01N21/65 ,  G01N21/4795 ,  G02B21/33 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/0697

Abstract: A stimulated Raman scattering tomography system includes means for generating a first input light beam, means for generating a second input light beam, an objective, a condenser and a detector. The first input light beam is phase-modulated while the second input light beam is amplitude-modulated. The objective is configured to direct the first and second input light beams onto a sample. The condenser is configured to collect an output light beam from the sample. The is detector configured to detect at least a portion of the output light beam corresponding to the first input light beam. The system further includes means for forming a depth-resolved image of the sample from the detected portion of the output light beam.

公开(公告)号：US20190128808A1

公开(公告)日：2019-05-02

申请号：US16226799

申请日：2018-12-20

Applicant: NxGen Partners IP, LLC

Inventor： SOLYMAN ASHRAFI

IPC: G01N21/59 ,  G01N33/483 ,  G01N21/3581 ,  G01N21/65 ,  G01N21/64 ,  G01N21/21 ,  G01N21/63 ,  G01N33/68 ,  G01N33/487 ,  A61B5/00

CPC classification number: G01N21/59 ,  A61B5/0075 ,  A61B2503/42 ,  G01N21/21 ,  G01N21/3581 ,  G01N21/636 ,  G01N21/6486 ,  G01N21/65 ,  G01N33/483 ,  G01N33/487 ,  G01N33/6896 ,  G01N2201/0675 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: An apparatus for detecting a material within a sample includes a light emitting unit for directing at least one light beam through the sample. A plurality of units receive the light beam that has passed through the sample and performs a spectroscopic analysis of the sample based on the received light beam. Each of the plurality of units analyze a different parameter with respect to the sample and provide a separate output signal with respect to the analysis. A processor detects the material with respect each of the provided separate output signals.

公开(公告)号：US10073076B2

公开(公告)日：2018-09-11

申请号：US15312054

申请日：2015-05-20

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Naoya Matsumoto ,  Koyo Watanabe ,  Hirotoshi Terada

IPC: G01B21/00 ,  G01N33/483 ,  G01B11/24 ,  G02B21/00 ,  G01N21/41 ,  G02B5/32 ,  G02B27/00 ,  G03H1/00 ,  G03H1/08 ,  G03H1/22 ,  G01N21/64 ,  G01N21/63

CPC classification number: G01N33/4833 ,  G01B11/24 ,  G01N21/41 ,  G01N21/636 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B5/32 ,  G02B21/00 ,  G02B21/16 ,  G02B27/0068 ,  G03H1/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0072

Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

公开(公告)号：US09874737B2

公开(公告)日：2018-01-23

申请号：US14890243

申请日：2014-05-07

Applicant: Forschungszentrum Mikroskopie (FZM), LuciaOptics gemeinnützige UG

Inventor： Gerrit Best ,  Christoph Cremer ,  Sabrina Rossberger ,  Stefan Dithmar

IPC: G02B21/36 ,  G01N21/64 ,  G02B21/00 ,  G02B21/16 ,  G02B27/58

CPC classification number: G02B21/367 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/361 ,  G02B27/58

Abstract: A fluorescence microscope for obtaining super-resolution images of a sample labeled with at least one fluorescent label by combining localization microscopy and structured illumination microscopy is provided. The fluorescence microscope includes one or more light sources, an illumination system having a structured illumination path for illuminating the sample with structured illumination light and a localization illumination path for illuminating the sample with localization illumination light.

公开(公告)号：US09733461B2

公开(公告)日：2017-08-15

申请号：US14580133

申请日：2014-12-22

Applicant: OLYMPUS CORPORATION

Inventor： Yasunari Matsukawa

IPC: H04N9/47 ,  H04N7/18 ,  G02B21/00 ,  G02B21/16 ,  G01N21/64

CPC classification number: G02B21/0032 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B21/0076 ,  G02B21/16

Abstract: To avoid unstable light radiation during switching of a phase modulation amount and stimulate desired stimulation points simultaneously, provided is a photo-stimulator which includes an AOM switching on/off of radiation of stimulation light to a specimen S; an LCOS-SLM being capable of modulating a phase of stimulation light once radiation to the specimen S has been turned on by the AOM; and a controller controlling the LCOS-SLM to switch a phase modulation amount of stimulation light and controlling the AOM to switch on/off of radiation of stimulation light, wherein the controller causes the AOM to turn off radiation of stimulation light before the LCOS-SLM starts switching a phase modulation amount, and causes the AOM to turn on radiation of stimulation light after the LCOS-SLM completes switching a phase modulation amount.

公开(公告)号：US09719927B2

公开(公告)日：2017-08-01

申请号：US15311311

申请日：2015-05-08

Applicant: TOHOKU UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Akihide Hibara ,  Manabu Tokeshi ,  Osamu Wakao

IPC: G01N21/64 ,  G02F1/13 ,  G01N33/542

CPC classification number: G01N21/6445 ,  G01J3/0224 ,  G01J4/00 ,  G01N21/64 ,  G01N21/6456 ,  G01N33/542 ,  G01N2201/0675 ,  G01N2201/0683 ,  G02F1/13

Abstract: An excitation light source emits excitation light to a target sample. An image sensor includes pixels arranged one-dimensionally or two-dimensionally, and receives measurement light from the sample according to the excitation light. A polarization selector arranged between the sample and image sensor includes pixels arranged one-dimensionally or two-dimensionally. Each pixel receives a corresponding portion of the measurement light, selects light having a polarization direction that corresponds to a driving signal applied to the pixels, and supplies this light to the image sensor. A measurement control unit supplies the cyclic driving signal having a first period T1, and acquires data I1, I2, I3, and I4 from each pixel of the image sensor for each exposure time segment T2=T1/4 obtained by dividing the first period T1 by 4.

公开(公告)号：US20160202178A1

公开(公告)日：2016-07-14

申请号：US14594956

申请日：2015-01-12

Applicant: Verily Life Sciences LLC

Inventor： Victor Marcel Acosta ,  Adam Backer ,  John D. Perreault ,  Daniele Paolo Piponi

IPC: G01N21/25 ,  G01J3/02 ,  G02B21/36

CPC classification number: G02B21/0064 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/18 ,  G01J3/502 ,  G01J2003/1278 ,  G01J2003/468 ,  G01N21/255 ,  G01N21/27 ,  G01N2201/06113 ,  G01N2201/0675 ,  G02B5/1828 ,  G02B6/2931 ,  G02B21/06 ,  G02B21/361 ,  G02B26/0808 ,  G02F1/133553 ,  G02F1/23 ,  G02F1/292 ,  G06T7/11 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30004 ,  H04N5/2256 ,  H04N5/332

Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.

公开(公告)号：US20160011113A1

公开(公告)日：2016-01-14

申请号：US14795491

申请日：2015-07-09

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Martin Müller ,  Nico Presser ,  Gunter Möhler

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008

Abstract: Method for the operation of a laser scanning microscope. The microscope includes an illumination beam path in which at least one illumination light source is arranged, a detection beam path in which at least one photomultiplier (PMT) is incorporated as detector, and a control unit for controlling fluorescence experiments. A sample is alternately illuminated at high intensity via the control unit, and the fluorescence decay behavior of sample points and/or sample regions is subsequently detected. The PMT is switched on and off depending on the illumination mode by the control unit via a switch directly in the high-voltage supply of the PMT.

Abstract translation: 激光扫描显微镜操作方法。 显微镜包括其中布置有至少一个照明光源的照明光束路径，其中结合有至少一个光电倍增管（PMT）作为检测器的检测光束路径，以及用于控制荧光实验的控制单元。 通过控制单元以高强度交替照射样品，随后检测样品点和/或样品区域的荧光衰减行为。 PMT根据控制单元的照明模式通过直接在PMT的高压电源中的开关来接通和关断。