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1.发明授权Evaluation circuit for an optoelectronic detector and method for recording fluorescence events 有权用于光电子检测器的评估电路和用于记录荧光事件的方法公开(公告)号：US09377405B2
公开(公告)日：2016-06-28
申请号：US14348261
申请日：2012-09-20
Applicant: Carl Zeiss Microscopy GmbH
Inventor： Gunter Möhler , Dietmar Schmidt , Oliver Holub , Robert Hauschild
CPC classification number: G01N21/64 , G01J1/44 , G01J3/2889 , G01J3/44 , G01N21/6408 , G01N21/6458 , G02B21/0076 , G02B21/0084
Abstract: An improved evaluation circuit which allows high sensitivity in an economical manner. For this purpose, a shift register having at least one data input, a clock input, a plurality of register stages and at least one data output is provided, wherein the output of the analog-to-digital converter is connected to the data input of the shift register. With a shift register, fluorescent light and scattered light can be temporally distinguished in an economical manner.
Abstract translation: 改进的评估电路，以经济的方式允许高灵敏度。 为此，提供具有至少一个数据输入，时钟输入，多个寄存器级和至少一个数据输出的移位寄存器，其中模数转换器的输出连接到 移位寄存器。 通过移位寄存器，可以以经济的方式在时间上区分荧光灯和散射光。
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公开(公告)号：US20160011113A1
公开(公告)日：2016-01-14
申请号：US14795491
申请日：2015-07-09
Applicant: Carl Zeiss Microscopy GmbH
Inventor： Martin Müller , Nico Presser , Gunter Möhler
IPC: G01N21/64
CPC classification number: G01N21/6408 , G01N21/6458 , G01N2201/06113 , G01N2201/067 , G01N2201/0675 , G02B21/0032 , G02B21/0076 , G02B21/008
Abstract: Method for the operation of a laser scanning microscope. The microscope includes an illumination beam path in which at least one illumination light source is arranged, a detection beam path in which at least one photomultiplier (PMT) is incorporated as detector, and a control unit for controlling fluorescence experiments. A sample is alternately illuminated at high intensity via the control unit, and the fluorescence decay behavior of sample points and/or sample regions is subsequently detected. The PMT is switched on and off depending on the illumination mode by the control unit via a switch directly in the high-voltage supply of the PMT.
Abstract translation: 激光扫描显微镜操作方法。 显微镜包括其中布置有至少一个照明光源的照明光束路径，其中结合有至少一个光电倍增管（PMT）作为检测器的检测光束路径，以及用于控制荧光实验的控制单元。 通过控制单元以高强度交替照射样品，随后检测样品点和/或样品区域的荧光衰减行为。 PMT根据控制单元的照明模式通过直接在PMT的高压电源中的开关来接通和关断。
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公开(公告)号：US09671341B2
公开(公告)日：2017-06-06
申请号：US14795491
申请日：2015-07-09
Applicant: Carl Zeiss Microscopy GmbH
Inventor： Martin Müller , Nico Presser , Gunter Möhler
CPC classification number: G01N21/6408 , G01N21/6458 , G01N2201/06113 , G01N2201/067 , G01N2201/0675 , G02B21/0032 , G02B21/0076 , G02B21/008
Abstract: Method for the operation of a laser scanning microscope. The microscope includes an illumination beam path in which at least one illumination light source is arranged, a detection beam path in which at least one photomultiplier (PMT) is incorporated as detector, and a control unit for controlling fluorescence experiments. A sample is alternately illuminated at high intensity via the control unit, and the fluorescence decay behavior of sample points and/or sample regions is subsequently detected. The PMT is switched on and off depending on the illumination mode by the control unit via a switch directly in the high-voltage supply of the PMT.
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4.发明申请Evaluation Circuit for an Optoelectronic Detector and Method for Recording Fluorescence Events 有权用于光电检测器的评估电路和用于记录荧光事件的方法公开(公告)号：US20140231675A1
公开(公告)日：2014-08-21
申请号：US14348261
申请日：2012-09-20
Applicant: Carl Zeiss Microscopy GmbH
Inventor： Gunter Möhler , Dietmar Schmidt , Oliver Holub , Robert Hauschild
IPC: G01N21/64
CPC classification number: G01N21/64 , G01J1/44 , G01J3/2889 , G01J3/44 , G01N21/6408 , G01N21/6458 , G02B21/0076 , G02B21/0084
Abstract: An improved evaluation circuit which allows high sensitivity in an economical manner. For this purpose, a shift register having at least one data input, a clock input, a plurality of register stages and at least one data output is provided, wherein the output of the analog-to-digital converter is connected to the data input of the shift register. With a shift register, fluorescent light and scattered light can be temporally distinguished in an economical manner.
Abstract translation: 改进的评估电路，以经济的方式允许高灵敏度。 为此，提供具有至少一个数据输入，时钟输入，多个寄存器级和至少一个数据输出的移位寄存器，其中模数转换器的输出连接到 移位寄存器。 通过移位寄存器，可以以经济的方式在时间上区分荧光灯和散射光。
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