公开(公告)号：US20230212643A1

公开(公告)日：2023-07-06

申请号：US17612000

申请日：2020-05-18

申请人： RENSSELAER POLYTECHNIC INSTITUTE

发明人： Xing WANG ,  Seok-Joon KWON ,  Jonathan Seth DORDICK ,  Robert John LINHARDT ,  Paul S. KWON

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C12N15/115

CPC分类号： C12Q1/68 ,  C12Q1/701 ,  C12N15/115 ,  C12N2310/16 ,  C12Q2600/16

摘要： The oligonucleotide nanostructures enable pattern-recognized targeting of diseases, particularly useful as high-specificity detectors and inhibitors of viruses and toxins, such as for Dengue virus particles. The nanostructures include an oligonucleotide scaffold with a plurality of binders arranged in a pattern conforming to a plurality of surface epitopes of a target disease. Binding of the scaffolds to these surface epitopes has been shown to have inhibitory effects against the target disease. The scaffolds can also include functional domains that activate upon target binding. Assembly of the scaffolds can be achieved via annealing of separate oligonucleotide segments of predetermined length and sequence, which also advantageously define locations of binding domains in the resulting structure. This approach provides precise control over the spacing and orientation of epitope binding sites in the scaffold.

公开(公告)号：US20230203114A1

公开(公告)日：2023-06-29

申请号：US18063430

申请日：2022-12-08

申请人： Immatics Biotechnologies GmbH

发明人： Oliver SCHOOR ,  Andrea MAHR ,  Toni WEINSCHENK ,  Anita WIEBE ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： C07K14/47 ,  A61P35/00 ,  A61K39/00 ,  C07K14/74 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/113 ,  C07K14/725 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61P35/00 ,  A61K39/001154 ,  A61K39/0011 ,  C07K14/70539 ,  C07K16/2833 ,  C12N5/0636 ,  C12N15/1138 ,  C07K14/7051 ,  C07K16/3046 ,  C07K16/3076 ,  C07K2317/34 ,  C12N2501/50 ,  C12N2310/16 ,  A61K2039/5154 ,  A61K2039/5158

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11685769B2

公开(公告)日：2023-06-27

申请号：US17366837

申请日：2021-07-02

申请人： Immatics Biotechnologies GmbH

发明人： Colette Song ,  Franziska Hoffgaard ,  Daniel Johannes Kowalewski ,  Oliver Schoor ,  Jens Fritsche ,  Toni Weinschenk ,  Harpreet Singh

IPC分类号： C07K14/47 ,  A61P35/02 ,  A61P35/00 ,  A61K39/00 ,  A61K35/17 ,  A61K45/06 ,  C07K14/725 ,  C07K14/74 ,  C07K16/28 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/115

CPC分类号： C07K14/4748 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/001186 ,  A61K39/001193 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/2833 ,  C07K16/30 ,  C07K16/303 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C12N5/0636 ,  C12N15/115 ,  C07K2319/00 ,  C12N2310/16

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11679147B2

公开(公告)日：2023-06-20

申请号：US17853344

申请日：2022-06-29

申请人： Immatics Biotechnologies GmbH

发明人： Toni Weinschenk ,  Andrea Mahr ,  Jens Fritsche ,  Phillip Mueller ,  Anita Wiebe ,  Sarah Kutscher

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61K38/04 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/725 ,  C07K14/74 ,  C07K16/18 ,  C12N5/0783 ,  C12N15/115 ,  G01N33/68 ,  A61K51/10 ,  A61K35/12

CPC分类号： A61K39/00111 ,  A61K35/17 ,  A61K38/04 ,  A61K39/0011 ,  A61K51/1057 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/18 ,  C12N5/0636 ,  C12N15/115 ,  G01N33/6803 ,  A61K2035/124 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K2317/70 ,  C07K2319/40 ,  C12N2310/16 ,  C12N2501/998

摘要： A method of eliciting an immune response in a patient who has a cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize the cancer cells in the patient that aberrantly express a peptide consisting of the amino acid sequence of GVLPGLVGV (SEQ ID NO: 56), in which the peptide is in a complex with an MHC molecule.

公开(公告)号：US20230172979A1

公开(公告)日：2023-06-08

申请号：US17504497

申请日：2020-04-16

申请人： The Methodist Hospital

发明人： Youli ZU

IPC分类号： A61K35/17 ,  C12N15/115 ,  C12N5/00 ,  C12N5/0783 ,  A61P35/02

CPC分类号： A61K35/17 ,  C12N15/115 ,  C12N5/0006 ,  C12N5/0646 ,  A61P35/02 ,  C12N2310/16 ,  C12N2310/3515

摘要： Disclosed are methods and compositions for diagnosis, imaging, and treating one or more mammalian diseases, including, for example, treatment, prophylaxis, and/or amelioration of one or more symptoms of a human cancer. Disclosed are compositions and methods for the treatment and amelioration of one or more symptoms of a disease, and in exemplary embodiments, for use as an immunotherapeutic.

公开(公告)号：US11667941B2

公开(公告)日：2023-06-06

申请号：US16961465

申请日：2019-01-14

申请人： CAMENA BIOSCIENCE LIMITED

发明人： Derek L. Stemple ,  Andrew G. Fraser ,  Sylwia Mankowska ,  Neil Bell

IPC分类号： C12P19/34 ,  C12N15/115

CPC分类号： C12P19/34 ,  C12N15/115 ,  C12N2310/16

摘要： Disclosed are compositions and methods for template-free nucleic acid synthesis.

公开(公告)号：US11655280B2

公开(公告)日：2023-05-23

申请号：US17738453

申请日：2022-05-06

申请人： Immatics Biotechnologies GmbH

发明人： Heiko Schuster ,  Daniel Johannes Kowalewski ,  Oliver Schoor ,  Jens Fritsche ,  Toni Weinschenk ,  Harpreet Singh ,  Gisela Schimmack ,  Michael Roemer

IPC分类号： C07K14/725 ,  C12N5/0783 ,  A61P35/00 ,  C07K16/28 ,  C07K14/74 ,  A61K35/17 ,  A61K39/00 ,  A61K38/00 ,  G01N33/574 ,  A61K9/19 ,  G16B25/10 ,  C12N15/115

CPC分类号： C07K14/7051 ,  A61K9/19 ,  A61K35/17 ,  A61K39/001111 ,  A61P35/00 ,  C07K14/70539 ,  C07K16/2809 ,  C07K16/2833 ,  C12N5/0638 ,  C12N15/115 ,  G01N33/57492 ,  G16B25/10 ,  A61K38/00 ,  C07K2319/00 ,  C12N2310/16

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20190249245A1

公开(公告)日：2019-08-15

申请号：US16262777

申请日：2019-01-30

申请人： Base Pair Biotechnologies, Inc.

发明人： George W. Jackson ,  Robert Batchelor ,  Rafal Drabek ,  Caitlin Bruns

IPC分类号： C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q1/6848 ,  C40B30/04

CPC分类号： C12Q1/6874 ,  C12N15/1048 ,  C12N15/115 ,  C12N2310/16 ,  C12N2330/31 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

摘要： The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as lipoarabinomannan (LAM).

公开(公告)号：US20190233824A1

公开(公告)日：2019-08-01

申请号：US16330813

申请日：2017-09-06

申请人： THE METHODIST HOSPITAL SYSTEM

发明人： Santhana Gowri THANGAVELU DEVARAJ ,  Swaminathan P. IYER

IPC分类号： C12N15/115 ,  A61P35/02 ,  A61K9/50 ,  C07K16/18 ,  A61K47/54 ,  A61K47/69

CPC分类号： C12N15/115 ,  A61K9/50 ,  A61K47/549 ,  A61K47/6925 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  C07K16/18 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2310/3517

摘要： The present disclosure relates to PD1-specific aptamers and methods of treating cancer.

公开(公告)号：US20190203271A1

公开(公告)日：2019-07-04

申请号：US16303647

申请日：2017-05-24

申请人： Atila Biosystems, Inc.

发明人： Youxiang WANG ,  Xin CHEN ,  Rong WANG ,  Zhijie YANG ,  Yu ZHAO

IPC分类号： C12Q1/6818 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6806

CPC分类号： C12Q1/6818 ,  C12N2310/16 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6846 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2525/205 ,  C12Q2525/301 ,  C12Q2531/119 ,  C12Q2537/143 ,  C12Q2561/109 ,  C12Q2565/1015

摘要： The present disclosure provides compositions, methods and kits for Omega amplification technologies. In addition, the present disclosure provides compositions, methods and kits for universal FQ probe and for G-quadruplex detection methods for use in isothermal amplification technologies.