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公开(公告)号：US20220257739A1
公开(公告)日：2022-08-18
申请号：US17728756
申请日：2022-04-25
发明人： Toni WEINSCHENK , Andrea MAHR , Jens FRITSCHE , Phillip MUELLER , Anita WIEBE , Sarah KUTSCHER
IPC分类号： A61K39/00 , A61K38/04 , C07K7/06 , C07K7/00 , C07K7/08 , A61K51/10 , A61K35/17 , C07K16/18 , C12N5/0783 , C12N15/115 , G01N33/68 , C07K14/435 , C07K14/725 , C07K14/74
摘要： A method of eliciting an immune response in a patient who has a cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize the cancer cells in the patient that aberrantly express a peptide consisting of the amino acid sequence of GVYDGEEHSV (SEQ ID NO: 303), in which the peptide is in a complex with an MHC molecule.
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公开(公告)号：US20220023403A1
公开(公告)日：2022-01-27
申请号：US17502170
申请日：2021-10-15
发明人： Toni WEINSCHENK , Andrea MAHR , Jens FRITSCHE , Phillip MUELLER , Anita WIEBE , Sarah KUTSCHER
IPC分类号： A61K39/00 , C07K7/08 , C12N15/115 , C12N5/0783 , C07K16/18 , C07K7/00 , A61K38/04 , G01N33/68 , C07K14/435 , C07K14/725 , C07K14/74 , A61K35/17 , C07K7/06
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules. In particular, the present invention relates to several novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses or as targets for the development of pharmaceutically/immunologically active compounds and cells.
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公开(公告)号：US20210252061A1
公开(公告)日：2021-08-19
申请号：US17229682
申请日：2021-04-13
发明人： Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： A61K35/17 , A61K39/00 , C07K14/47 , C07K14/74 , C07K16/28 , C07K16/30 , C12N5/0783 , A61K35/16 , A61K39/39
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20210085767A1
公开(公告)日：2021-03-25
申请号：US17076535
申请日：2020-10-21
发明人： Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： A61K39/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/74 , C07K16/28 , C12N15/115 , C12N5/0783 , A61K35/17 , A61K38/08
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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5.发明申请公开(公告)号：US20200323912A1
公开(公告)日：2020-10-15
申请号：US16911028
申请日：2020-06-24
发明人： Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： A61K35/17 , C12N5/0783 , A61K39/39
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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6.发明申请公开(公告)号：US20200054727A1
公开(公告)日：2020-02-20
申请号：US16669622
申请日：2019-10-31
发明人： Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： A61K39/00 , C07K16/28 , C07K14/74 , C12N15/115 , C12N5/0783 , C07K16/30 , C07K14/725 , C07K14/47 , C07K7/08 , C07K7/06
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20180251507A1
公开(公告)日：2018-09-06
申请号：US15982397
申请日：2018-05-17
发明人： Oliver SCHOOR , Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61K39/00 , C07K16/30 , C07K14/74 , C07K16/28 , C12N5/0783 , C07K14/725 , C12N15/113
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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8.发明申请公开(公告)号：US20180207253A1
公开(公告)日：2018-07-26
申请号：US15918788
申请日：2018-03-12
发明人： Toni WEINSCHENK , Andrea MAHR , Jens FRITSCHE , Phillip MUELLER , Anita WIEBE , Sara KUTSCHER
IPC分类号： A61K39/00 , G01N33/68 , C07K14/725 , A61K38/04 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435 , A61K35/17 , C12N15/115 , C12N5/0783 , C07K16/18 , C07K14/74 , A61K35/12
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/04 , A61K2035/124 , A61K2039/5154 , A61K2039/5158 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/7051 , C07K14/70539 , C07K16/18 , C07K2317/70 , C07K2319/40 , C12N5/0636 , C12N15/115 , C12N2310/16 , C12N2501/998 , G01N33/6803
摘要： A method of eliciting an immune response in a patient who has a cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize the cancer cells in the patient that aberrantly express a peptide consisting of the amino acid sequence of GVYDGEEHSV (SEQ ID NO: 303), in which the peptide is in a complex with an MHC molecule.
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公开(公告)号：US20170342125A1
公开(公告)日：2017-11-30
申请号：US15602746
申请日：2017-05-23
发明人： Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Oliver SCHOOR , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/74 , C07K7/06 , C07K7/08 , C07K14/725 , C12Q1/68 , C07K16/30 , C12N5/0783 , C12N15/115 , A61K39/00 , G01N33/50 , G01N33/574 , C07K16/28
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230212244A1
公开(公告)日：2023-07-06
申请号：US18063418
申请日：2022-12-08
发明人： Oliver SCHOOR , Andrea MAHR , Toni WEINSCHENK , Anita WIEBE , Jens FRITSCHE , Harpreet SINGH
IPC分类号： C07K14/47 , A61P35/00 , A61K39/00 , C07K14/74 , C07K16/28 , C12N5/0783 , C12N15/113 , C07K14/725 , C07K16/30
CPC分类号： C07K14/4748 , A61K39/0011 , A61K39/001154 , A61P35/00 , C07K14/7051 , C07K14/70539 , C07K16/2833 , C07K16/3046 , C07K16/3076 , C12N5/0636 , C12N15/1138 , A61K2039/5154 , A61K2039/5158 , C07K2317/34 , C12N2310/16 , C12N2501/50
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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