摘要:
The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.
摘要:
The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a polypeptide having an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino-acid residue at position 175 to the amino-acid residue at position 191 in SEQ ID NO:1.
摘要翻译:本发明涉及多肽及其用于减少CD95-沉默的细胞运动性的用途。 具体地说,本发明涉及一种多肽,其氨基酸序列与氨基酸序列具有至少70%的同一性,其氨基酸序列范围从SEQ ID NO中的第175位的氨基酸残基至第191位的氨基酸残基 :1。
摘要:
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
摘要:
The disclosure relates to a device including a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.
摘要:
An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
摘要:
A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.
摘要:
A method for simulating a deep-brain stimulation in a computer-assisted platform that includes providing to a neurosurgeon, through a man-machine interface, visual information of a pre-operative situation, including a representation of a brain. The method also includes monitoring inputs of said neurosurgeon on the man-machine interface, until a trajectory is determined between an entry point and a target for the placement of an electrode. The method further includes comparing said trajectory to a set of previously-established trajectories for the pre-operative situation, so as to determine an overall measurement representative of a quality of the trajectory compared to the previously-established trajectories.
摘要:
A process for preparing a polyaminoborane comprising reacting at least one monomer with an aminoborane, wherein the at least one monomer is selected from the group consisting of ammonia, a primary amine and a substituted or unsubstituted hydrazine; and wherein the aminoborane comprises a borane substituted by a secondary amino group; polyaminoboranes obtainable by said process; use of said polyaminoboranes for the preparation of a ceramic precursor or a ceramic, the production of boron nitride, or the storage and/or production of dihydrogen; ceramic precursors, ceramics, hydrogen cells or energy materials comprising said polyaminoboranes.
摘要:
The invention relates to a device (LIGHT) for lighting a graphic and/or textual content present on any medium and in particular on a paper medium. The lighting device (LIGHT) is configured to periodically activate and deactivate said lighting beam in successive cycles carried out at a preset frequency Fd. Each cycle has a duration T and comprises a period of activation of the light beam of duration T1 followed by a period of deactivation of the light beam of duration T2 or vice versa. The frequency Fd is comprised in an interval of values ranging from 60 to 90 Hz and the duration T1 of the periods of activation of the light beam is comprised in an interval of values ranging from 15 to 30% of the duration T of the cycles.
摘要:
A system for estimating physical parameter(s) of a medium having electrolyte(s), including at least one working electrode; one counter electrode; a current generator delivering to the electrodes electric current pulses; a computer-readable memory including a predefined analytic model of an electric potential, between the working and counter electrodes, as a function of time, receiving as inputs the current and current pulse duration and including the physical parameter to be estimated; an acquisition unit including a signal amplifier for acquiring and amplifying an electric potential recorded by the electrodes; a processor including a stimulation module controlling the current generator to deliver a biphasic charge-balanced current during a stimulation duration; an acquisition module acquiring an electric potential variation during the stimulation duration; and a calculation module receiving the acquired electric potential variation, fitting the acquired electric potential variation using the predefined analytic model, and outputting the estimated physical parameter.