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公开(公告)号：US11604361B2
公开(公告)日：2023-03-14
申请号：US16765278
申请日：2018-08-03
发明人： Albert Le Floch , Guy Ropars
摘要： The invention relates to an optical device (FILT) for filtering light received, by polarisation or mechanically, from a medium presenting a graphic and/or textual content, characterized in that cycles of opening and closing a vision space, in a visible light spectrum, are realized periodically using the optical device (FILT) at a preset frequency Fd and in that the successive open periods each have a duration (T1) comprised in an interval of values ranging from 15 to 35% of the duration (T) of the realized cycles.
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公开(公告)号：US20220396773A1
公开(公告)日：2022-12-15
申请号：US17776053
申请日：2020-11-13
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE RENNES 1 , ÉCOLE DES HAUTES ÉTUDES EN SANTÉ PUBLIQUE (EHESP)
发明人： Georges BAFFET , Marie CUVELLIER , Frédéric EZAN , Sophie ROSE
摘要： A method of obtaining 3D cell structures including differentiated human hepatic cells. The method includes: a first step of culturing stem cell-derived or immortalized human hepatic progenitors in a non-adherent culture vessel, preferably a low or ultra-low attachment culture vessel; a second step of transferring the stem cell-derived or immortalized human hepatic progenitors to a culture medium including methacrylated gelatin (GelMa), thereby embedding the stem cell-derived or immortalized human hepatic progenitors in a GelMa matrix; and a third step of covering the GelMa matrix with culture medium and culturing the stem cell-derived or immortalized human hepatic progenitors embedded in the GelMa matrix, thereby obtaining 3D cell structures including differentiated human hepatic cells. Also, methods for engineering an artificial liver model or an artificial liver organ, and for assessing in vitro the metabolism, toxicity and/or therapeutic effects of a compound.
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公开(公告)号：US11467160B2
公开(公告)日：2022-10-11
申请号：US16612153
申请日：2018-05-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Rennes 1 , Centre Eugene Marquis , Enios Applications Private Limited Company
IPC分类号： G01N33/574 , A61P35/00 , A61K31/506
摘要： The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.
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公开(公告)号：US20210183340A1
公开(公告)日：2021-06-17
申请号：US16764737
申请日：2018-08-03
发明人： Albert LE FLOCH , Guy ROPARS
摘要： A method for displaying graphical content in a playback device, the graphical content being displayed and erased periodically on the display device according to successive cycles that take place at a predetermined frequency (Fd) and in that the successive display periods each have a duration (T1) comprised in an interval of values ranging from 15 to 30% of the duration (T) of the cycles that have taken place.
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公开(公告)号：US20200310141A1
公开(公告)日：2020-10-01
申请号：US16765278
申请日：2018-08-03
发明人： Albert LE FLOCH , Guy ROPARS
摘要： The invention relates to an optical device (FILT) for filtering light received, by polarisation or mechanically, from a medium presenting a graphic and/or textual content, characterized in that cycles of opening and closing a vision space, in a visible light spectrum, are realized periodically using the optical device (FILT) at a preset frequency Fd and in that the successive open periods each have a duration (T1) comprised in an interval of values ranging from 15 to 35% of the duration (T) of the realized cycles.
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6.发明申请DEVICE FOR THE TREATMENT OF SLEEP APNEA SYNDROME IN A PATIENT BY KINESTHETIC STIMULATION 审中-公开通过生殖刺激治疗患者睡眠APNEA综合征的手段公开(公告)号：US20150224018A1
公开(公告)日：2015-08-13
申请号：US14617534
申请日：2015-02-09
申请人： SORIN CRM SAS , INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , UNIVERSITÉ DE RENNES 1 , UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
发明人： Laurence Graindorge , Amel Amblard , Christine Henry , Marcel Limousin , Laure Duchemin Laporte , Alfredo Hernandez , Jean-Louis Pépin
IPC分类号： A61H23/00
CPC分类号： A61H23/00 , A61B5/024 , A61B5/4812 , A61B5/4818 , A61H23/02 , A61H2201/10 , A61H2201/165 , A61H2201/5058 , A61H2230/04 , A61H2230/06 , A61H2230/105
摘要： A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient
摘要翻译： 用于通过刺激治疗患者的睡眠呼吸暂停的装置。 该装置包括被配置为产生刺激脉冲的发生器，接收由发生器产生的刺激脉冲并将刺激传送给患者的刺激器以及控制器。 控制器被配置为确定患者的睡眠状态，基于休眠状态包括多个睡眠阶段的睡眠状态自适应地控制发生器，并且基于睡眠来调制由发生器产生的刺激脉冲的刺激能量 患者阶段
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公开(公告)号：US11066649B2
公开(公告)日：2021-07-20
申请号：US15125596
申请日：2015-03-19
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE PARIS—SUD , UNIVERSITÉ DE RENNES
IPC分类号： C12N5/071 , A61K35/407
摘要： The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
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公开(公告)号：US20210080461A1
公开(公告)日：2021-03-18
申请号：US16612153
申请日：2018-05-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Rennes 1 , Centre Eugene Marquis , Enios Applications Private Limited Company
IPC分类号： G01N33/574 , A61K31/506 , A61P35/00
摘要： The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.
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公开(公告)号：US10519365B2
公开(公告)日：2019-12-31
申请号：US15120977
申请日：2015-02-24
IPC分类号： C09K11/02 , C09K11/54 , H05B33/14 , H01L51/50 , H01L51/00 , C07F9/6568 , C09K11/06 , H01L51/44 , B82Y20/00 , B82Y40/00
摘要： A luminescent hybrid nanomaterial comprising: at least one inorganic nanomaterial comprising an inorganic first compound; and at least one second compound comprising a first aggregation-induced emission moiety, wherein the at least one second compound is grafted on at least part of a surface of the inorganic first compound.
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10.发明申请公开(公告)号：US20190312655A1
公开(公告)日：2019-10-10
申请号：US16347412
申请日：2017-11-03
摘要： A method for determining a distance to a passive intermodulation source in a device under test, the method comprising transmitting at least two signals with respective different frequencies to the device under test, receiving a complex response signal from the device under test, the complex response signal comprising a passive intermodulation of the at least two signals, generating an autocorrelation matrix using the complex response signal, the autocorrelation matrix representing power information of the complex response signal, decomposing the complex response signal, using the autocorrelation matrix, into a signal component part and a noise component part and determining a distance to the passive intermodulation source in the device under test using the noise and/or signal component part.
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