公开(公告)号：US20160158093A1

公开(公告)日：2016-06-09

申请号：US14961403

申请日：2015-12-07

申请人： SORIN CRM SAS ,  INSERM- INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ JOSEPH FOURIER ,  UNIVERSITÉ DE RENNES 1

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61H23/00

CPC分类号： A61H23/004 ,  A61B5/04 ,  A61B5/08 ,  A61B5/4818 ,  A61B5/4836 ,  A61H23/02 ,  A61H39/007 ,  A61H2201/10 ,  A61H2201/5007 ,  A61H2201/5012 ,  A61H2205/027 ,  A61M21/02 ,  A61M2021/0022 ,  A61M2205/505 ,  A61M2230/06 ,  A61M2230/205 ,  A61M2230/42 ,  A61N1/36 ,  G06F19/00 ,  G06F19/3481 ,  A61M2230/005

摘要： The disclosure relates to a device including a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.

摘要翻译： 本公开涉及一种包括处理器的设备，其被配置为响应于呼吸障碍发作的检测而检测呼吸障碍发作并产生运动刺激控制信号。 该装置还包括至少一个适用于患者外皮肤部位的运动效应器，并且包括能够接收刺激控制信号并输出​​由刺激控制信号确定的运动刺激能量的振动机电换能器。 处理器还被配置为通过检测呼吸障碍发作的停止来确定刺激的有效性。 处理器还被配置为通过选择初始能量值并根据先前刺激的有效性改变能量值来确定刺激能量。

公开(公告)号：US10292898B2

公开(公告)日：2019-05-21

申请号：US14961403

申请日：2015-12-07

申请人： SORIN CRM SAS ,  INSERM-INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ JOSEPH FOURIER ,  UNIVERSITÉ DE RENNES 1

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61B5/00 ,  A61H23/00 ,  G06F19/00 ,  A61H23/02 ,  A61B5/04 ,  A61B5/08 ,  A61H39/00 ,  A61N1/36 ,  A61M21/00 ,  A61M21/02

摘要： A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.

公开(公告)号：US10299984B2

公开(公告)日：2019-05-28

申请号：US14961379

申请日：2015-12-07

申请人： SORIN CRM SAS ,  INSERM-INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ JOSEPH FOURIER ,  UNIVERSITÉ DE RENNES 1

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61H23/00 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0205 ,  A61B5/08 ,  A61H23/02 ,  A61B5/0402

摘要： A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.

公开(公告)号：US10292897B2

公开(公告)日：2019-05-21

申请号：US14961348

申请日：2015-12-07

申请人： SORIN CRM SAS ,  INSERM—INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ JOSEPH FOURIER ,  UNIVERSITÉ DE RENNES 1

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61H23/00 ,  A61B5/00 ,  A61N1/36 ,  A61H23/02

摘要： A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.

公开(公告)号：US20160158092A1

公开(公告)日：2016-06-09

申请号：US14961379

申请日：2015-12-07

申请人： SORIN CRM SAS ,  UNIVERSITÉ DE RENNES 1 ,  UNIVERSITÉ JOSEPH FOURIER ,  INSERM- INSTITUT DE LA RECHERCHE MÉDICALE

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61H23/00

CPC分类号： A61H23/004 ,  A61B5/0205 ,  A61B5/0402 ,  A61B5/0826 ,  A61B5/4818 ,  A61B5/4836 ,  A61H23/02 ,  A61H2201/10 ,  A61H2201/5007 ,  A61H2201/5012 ,  A61H2205/027 ,  A61N1/3611

摘要： The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.

摘要翻译： 本公开涉及一种包括处理器的系统，其被配置为响应于呼吸障碍的检测而产生刺激控制信号。 该系统还包括至少一个动觉效应器，其具有施加到患者皮肤上的位置的振动机电换能器，用于传递由控制信号确定的运动刺激能量。 处理器还被配置为通过检测呼吸障碍的停止来确定刺激的有效性。 处理器还被配置为在呼吸障碍停止之后将刺激控制信号延长一个确定的持续时间。

公开(公告)号：US20160158091A1

公开(公告)日：2016-06-09

申请号：US14961348

申请日：2015-12-07

申请人： SORIN CRM SAS ,  INSERM- INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ JOSEPH FOURIER ,  UNIVERSITÉ DE RENNES 1

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61H23/00

CPC分类号： A61H23/004 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/4818 ,  A61B5/4836 ,  A61B5/4848 ,  A61H23/02 ,  A61H2201/5015 ,  A61H2201/5058 ,  A61H2230/065 ,  A61H2230/207 ,  A61H2230/405 ,  A61N1/3611

摘要： The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.

摘要翻译： 本公开涉及一种包括处理器的系统，其被配置为响应于呼吸障碍的检测而产生刺激控制信号。 该系统还包括至少一个动觉效应器，其具有施加到患者皮肤上的位置的振动机电换能器，用于传递由控制信号确定的运动刺激能量。 处理器还被配置为通过检测呼吸障碍的消失来确定刺激的有效性。 处理器还被配置为根据预期或检测到的病症的类型在几种刺激策略之中选择刺激策略来确定治疗。

公开(公告)号：US20160113571A1

公开(公告)日：2016-04-28

申请号：US14922539

申请日：2015-10-26

申请人： SORIN CRM SAS ,  INSERM - INSTITUT DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ DE RENNES 1 ,  UNIVERSITÉ JOSEPH FOURIER

发明人： Amel Amblard ,  Laurence Graindorge ,  Delphine Feuerstein ,  Alfredo Hernandez ,  Jean-Louis Pépin

IPC分类号： A61B5/00 ,  A61B5/0488 ,  A61B5/0476 ,  A61B5/145 ,  A61B5/0205

CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0809 ,  A61B5/087 ,  A61B5/14542 ,  A61B5/4818 ,  A61B5/7282 ,  A61H23/00 ,  A61H2230/405 ,  A61N1/3611 ,  A61N1/36521

摘要： The invention relates to an active implantable medical device. The device measures for respiratory activity and for detection of a ventilation rate fall event below a predetermined threshold. The device analyzes in real time the various parameters of the ventilation rate fall event and determines whether they satisfy predefined criteria, so as to allocate or not a priori hypopnea suspicion indicator to the event. An anti-hypopnea therapy is selectively triggered on detection of respiratory collapse, but only in the case of current events indicating a priori hypopnea suspicion. The criteria may include: history of intervals between successive events constituting hypopnea episodes; severity of the current event; conformity of a current event profile with a reference profile; physiological, obstructive or central, origin of the event; patient's current sleep stage; and history of the degree of efficacy of the therapies.

摘要翻译： 本发明涉及一种有源可植入医疗装置。 该装置测量呼吸活动并检测通气率下降事件低于预定阈值。 该装置实时分析通气率下降事件的各种参数，并确定它们是否满足预定义的标准，以便为事件分配或不分配先天性呼吸不足怀疑指标。 在呼吸衰竭的检测中选择性地触发了抗呼吸不足治疗，但仅在当前事件表明先天性呼吸不足怀疑的情况下才被触发。 标准可以包括：构成呼吸不足事件的连续事件间隔的历史; 当前事件的严重性; 当前事件简档与参考资料的一致性; 生理，阻塞或中枢，事件的起源; 患者目前的睡眠阶段; 和治疗疗效程度的历史。