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124 条记录 (耗时 0.024 秒)

    Adhesion Preventive Material
    31.
    发明申请
    Adhesion Preventive Material 有权
    粘合预防材料

    公开(公告)号：US20080058469A1

    公开(公告)日：2008-03-06

    申请号：US10592956

    申请日：2005-03-11

    申请人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

    发明人： Yoshihiko Abe ,  Yutaro Sonoda ,  Jun Konishi ,  Takao Anzai ,  Miyuki Shimizu

    IPC分类号： A61L31/00 ,  A61K31/715 ,  A61P41/00 ,  C08B31/02

    CPC分类号： A61L31/042 ,  A61K31/715 ,  C08B31/02 ,  C08B37/0012 ,  C08B37/0018 ,  C08B37/0021

    摘要： An adhesion preventive material including a cross-linking polysaccharide derivative containing at least one active ester group introduced in a polysaccharide side chain, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked material due to covalent binding among the active ester group and an active hydrogen-containing group upon contact with water under an alkaline condition, is disclosed. The adhesion preventive material is able to reduce preparation works to be carried out while previously estimating the time of application and dose not require a special device.

    摘要翻译： 一种防粘连材料，包括含有至少一种引入多糖侧链的活性酯基的交联多糖衍生物，其能够与含活性氢基团反应，并且能够由于共价结合而形成交联材料 在碱性条件下与水接触时，活性酯基和活性含氢基团中。 防粘连材料能够减少准备工作，同时预先估计施药时间，不需要特殊装置。

    Camptothecin derivatives
    32.
    发明授权
    Camptothecin derivatives 失效
    喜树碱衍生物

    公开(公告)号：US06512118B1

    公开(公告)日：2003-01-28

    申请号：US09227158

    申请日：1999-01-08

    申请人： Kenji Tsujihara ,  Takayuki Kawaguchi ,  Satoshi Okuno ,  Toshiro Yano

    发明人： Kenji Tsujihara ,  Takayuki Kawaguchi ,  Satoshi Okuno ,  Toshiro Yano

    IPC分类号： C07D47100

    CPC分类号： C08B37/0018 ,  A61K47/61 ,  A61K47/65 ,  C08B37/0021

    摘要： A camptothecin derivative comprising a compound of the formula [I] is disclosed: wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is —Xn-Alkm-R6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by —Xn-Alkm-R6, and the remaining three groups are H, alkyl or a halogen, and one or two —CH2— of the alkylene in (A) or (B) may optionally be replaced by —O—, —S— or —NH—, X is —O— or —NH—, Alk is alkylene, R6 is —NH2, or —OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.

    摘要翻译： 公开了包含式[I]化合物的喜树碱衍生物：其中R1，R2，R3，R4和R5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，其余三个基团之一是 -Xn-Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn-Alkm-R6取代， 并且其余三个基团是H，烷基或卤素，并且（A）或（B）中亚烷基的一个或两个-CH 2可以任选地被-O - ， - S-或-NH-代替，X是 -O-或-NH-，Alk为亚烷基，R6为-NH2或-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物与具有羧基的多糖结合 通过氨基酸或肽，或其药学上可接受的盐。 所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

    Pullulan copolymer
    35.
    发明授权
    Pullulan copolymer 失效
    支链淀粉共聚物

    公开(公告)号：US4618664A

    公开(公告)日：1986-10-21

    申请号：US689928

    申请日：1985-01-09

    申请人： Yasuhiko Ohnishi

    发明人： Yasuhiko Ohnishi

    IPC分类号： A61L27/16 ,  A61L27/20 ,  A61L27/52 ,  C08B37/00 ,  C08F251/00 ,  G02B1/04 ,  C08F36/00

    CPC分类号： C08F251/00 ,  A61L27/16 ,  A61L27/20 ,  A61L27/52 ,  C08B37/0018 ,  G02B1/043

    摘要： A pullulan copolymer obtained by reacting with a polymerizable olefinic compound a pullulan ester which is produced by reacting pullulan with an unsaturated acid to introduce a double bond of carbon thereinto. It is highly hydrophilic and is a material having a high affinity for a living body and which is, therefore, useful for making contact lenses, intraocular lenses, artificial bones and blood vessels, etc.

    摘要翻译： 通过使可聚合烯烃化合物与支链淀粉酯与不饱和酸反应以引入碳双键制备的支链淀粉得到的支链淀粉共聚物。 它是高亲水性的，并且是对活体具有高亲和力的材料，因此可用于制造隐形眼镜，人工晶状体，人造骨和血管等。

    Cross-linked pullulan
    36.
    发明授权
    Cross-linked pullulan 失效
    交联支链淀粉

    公开(公告)号：US4152170A

    公开(公告)日：1979-05-01

    申请号：US695762

    申请日：1976-06-14

    申请人： Tsuneyuki Nagase ,  Kozo Tsuji ,  Masanori Fujimoto ,  Fujio Masuko

    发明人： Tsuneyuki Nagase ,  Kozo Tsuji ,  Masanori Fujimoto ,  Fujio Masuko

    IPC分类号： C08B37/00 ,  C08L5/00

    CPC分类号： C08B37/0018

    摘要： Cross-linked pullulans are obtained by the reaction of pullulan with a cross-linking agent selected from the group consisting of polycarboxylic acids, halogenated dicarboxylic acids, polycarboxylic anhydrides, aldehyde compounds, N-methylol compounds, isocyanate compounds, metaphosphoric acid salts, divinyl compounds, bis-aziridine and bifunctional compounds of the formula,X--R--Zwherein X and Z are each a halogen atom or an epoxy group and R is an aliphatic residue having 1 to 30 carbon atoms, in a solvent, and are useful as gels or beds for chromatography or in various fields requiring high degrees of water absorbency and retention.

    摘要翻译： 通过支链淀粉与选自多元羧酸，卤代二羧酸，多羧酸酐，醛化合物，N-羟甲基化合物，异氰酸酯化合物，偏磷酸盐，二乙烯基化合物的交联剂的反应获得交联的起始链优化 ，双氮丙啶和下式的双官能化合物XRZ，其中X和Z各自为卤素原子或环氧基，R为具有1至30个碳原子的脂族残基，并且可用作凝胶或床 色谱法或需要高吸水度和保留度的各种领域。

    Method for purifying pullulan
    37.
    发明授权
    Method for purifying pullulan 失效
    净化{i支链淀粉的方法

    公开(公告)号：US4004977A

    公开(公告)日：1977-01-25

    申请号：US543071

    申请日：1975-01-22

    申请人： Koso Kato ,  Tatsuo Nomura

    发明人： Koso Kato ,  Tatsuo Nomura

    IPC分类号： C12P19/12 ,  C08B37/00 ,  C12P19/10 ,  C12R1/645 ,  C12D13/04

    CPC分类号： C08B37/0018 ,  C12P19/10

    摘要： A method for purifying pullulan which comprises cultivating a strain of Aureobasidium pullulans in a liquid medium, removing the cells from the culture broth, precipitating pullulan present in said broth with at least one solvent selected from the group consisting of alcohols, esters and ethers respectively with three or more carbon atoms and ketones with four or more carbon atoms to recover, and then dehydrating and/or drying the recovered pullulan.

    摘要翻译： 一种纯化支链淀粉的方法，其包括在液体培养基中培养优质短梗霉属菌株，从培养液中除去细胞，用选自醇，酯和醚的至少一种溶剂分别沉淀存在于所述肉汤中的支链淀粉， 三个或更多个碳原子和具有四个或更多个碳原子的酮回收，然后脱水和/或干燥回收的支链淀粉。

    Shaped bodies of pullulan and their use
    38.
    发明授权
    Shaped bodies of pullulan and their use 失效
    PULLULAN的形状及其使用

    公开(公告)号：US3784390A

    公开(公告)日：1974-01-08

    申请号：US3784390D

    申请日：1972-07-13

    申请人： HAYASHIBARA BIOCHEM LAB

    发明人： HIJIYA H ,  SHIOSAKA M

    IPC分类号： A23L29/269 ,  A61K9/48 ,  C08B37/00 ,  C08L5/00 ,  C08L89/00 ,  C12P19/10 ,  D01F9/00 ,  C08H1/00 ,  C08H7/00

    CPC分类号： D01F9/00 ,  A23L29/274 ,  A61K9/4816 ,  C08B37/0018 ,  C08K5/053 ,  C08L3/12 ,  C08L5/00 ,  C08L29/04 ,  C08L89/06 ,  C12P19/10 ,  C08L2666/02

    摘要： Pullulan, a water-soluble polysaccharide produced by Pullularia pullulans from conventional culture media and consisting of repeating units of maltotriose linked by Alpha -1,6 bonds, can be shaped by compression molding or extrusion at elevated temperature or by evaporation of water from its aqueous solutions to form shaped bodies, such as films or coatings which are practically impermeable to atmospheric oxygen in thin layers and unaffected by oils and fats so as to provide valuable packing materials for food, pharmaceuticals, and other oxygen sensitive materials. Pullulan is edible and biodegradable.

    摘要翻译： 支链淀粉是由常规培养基中的普鲁氏菌属（Pullularia）支链淀粉生成的水溶性多糖，由由α-1,6键连接的麦芽三糖重复单元组成，可以通过在高温下压缩成型或挤出来形成，或通过从其水溶液中蒸发水 形成诸如膜或涂层的成形体的溶液，其实际上不透气于薄层中的大气氧并且不受油和脂肪影响，从而为食品，药物和其它氧敏感材料提供有价值的包装材料。 支链淀粉是可食用和可生物降解的。

    METHOD FOR EXTRACTING PULLULAN POLYSACCHARIDE FROM HIGH-VISCOSITY FERMENTATION BROTH
    40.
    发明公开
    METHOD FOR EXTRACTING PULLULAN POLYSACCHARIDE FROM HIGH-VISCOSITY FERMENTATION BROTH 审中-公开

    公开(公告)号：US20240247082A1

    公开(公告)日：2024-07-25

    申请号：US18627748

    申请日：2024-04-05

    申请人： TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY

    发明人： Changsheng QIAO ,  Ganggang CHENG ,  Liang LU ,  Tingbin ZHAO ,  Zhenhai LI

    IPC分类号： C08B37/00

    CPC分类号： C08B37/0003 ,  C08B37/0018

    摘要： A method for extracting pullulan polysaccharide from high-viscosity fermentation broth includes following steps: (1) removing cells from the fermentation broth; (2) removing proteins; (3) decolorizing by macroporous resin adsorption; (4) removing ions by ultrafiltration; and (5) drying, crushing and packaging. In the extraction method of the present application, by using natural polymer bioflocculant chitosan, the high-viscosity fermentation broth can be processed without dilution and addition of filter aids and organic solvents for alcohol precipitation, which reduces the pressure of subsequent decolorization, properly recycles the cell proteins, and avoids the potential hazard of the organic solvents. The method can obtain high-purity pullulan polysaccharide, improving the product yield and quality, reducing solid waste, reducing the production cost, and achieving a safe, efficient, continuous and automated production process.