知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

144 records (took 0.015 seconds)

    Compositions, the Preparation and Use Thereof
    31.
    发明申请
    Compositions, the Preparation and Use Thereof 审中-公开
    组合物，其制备和应用

    公开(公告)号：US20150038400A1

    公开(公告)日：2015-02-05

    申请号：US14458446

    申请日：2014-08-13

    Applicant: KCI Licensing, Inc.

    Inventor： Neal Vail

    IPC: A61L24/10 ,  A61L24/08

    CPC classification number: A61L24/10 ,  A01N57/12 ,  A61K38/02 ,  A61K47/42 ,  A61L24/08 ,  C07K14/78

    Abstract: The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions. In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, biocompatiblility, and/or biodegradability. The compositions can have the ability of promoting cell attachment, cell adhesion, cell migration, cell differentiation, and/or morphogenesis. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.

    Abstract translation: 本教导提供了包含聚阳离子和聚阳离子的新组合物，以及这些新组合物的制备和用途。 一方面，新组合物是复合凝聚剂。 本文所述的组合物可以具有几种所需的性质，包括在水中的低界面张力，可调节的内聚强度，抗微生物活性，在生理pH附近或附近溶解的适合性，生物相容性和/或生物降解性。 组合物可以具有促进细胞附着，细胞粘附，细胞迁移，细胞分化和/或形态发生的能力。 因此，在各种实施方案中，复合凝聚层可用于例如在体内的水基应用。

    METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN
    37.
    发明申请
    METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN 审中-公开
    蛋白质的酶交联方法

    公开(公告)号：US20110086014A1

    公开(公告)日：2011-04-14

    申请号：US12999632

    申请日：2009-06-18

    Applicant: Ishay Attar ,  Orahn Preiss-Bloom

    Inventor： Ishay Attar ,  Orahn Preiss-Bloom

    IPC: A61K38/45 ,  A61K38/43 ,  A61P43/00 ,  A61P17/02

    CPC classification number: A61L24/0031 ,  A61L24/10 ,  A61L24/108

    Abstract: A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme.

    Abstract translation: 用于交联白蛋白以用作生物系统的密封剂或胶水的方法，例如诱导止血和/或防止任何其它流体从生物管或组织例如淋巴液泄漏。 交联的白蛋白可以任选并优选作为绷带的一部分施用。 在其它实施方案中，本发明提供了通过改变蛋白质的结构来改善蛋白质对交联酶的可及性的酶促交联球形蛋白质的方法。

    Biocompatible phase invertable proteinaceous compositions and methods for making and using the same
    38.
    发明授权
    Biocompatible phase invertable proteinaceous compositions and methods for making and using the same 有权
    生物相容性相可逆蛋白质组合物及其制备和使用方法

    公开(公告)号：US07871639B2

    公开(公告)日：2011-01-18

    申请号：US11877396

    申请日：2007-10-23

    Applicant: Kemal Schankereli ,  Ronald Dieck

    Inventor： Kemal Schankereli ,  Ronald Dieck

    IPC: A61F2/02 ,  A61F2/06 ,  A61M5/00

    CPC classification number: C09J189/00 ,  A61K9/0024 ,  A61K47/42 ,  A61L24/0021 ,  A61L24/10 ,  A61L29/044 ,  A61L31/043

    Abstract: Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a plasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

    Abstract translation: 提供了生物相容性相可逆蛋白质组合物及其制备和使用方法。 通过组合蛋白质底物和交联剂制备目标相可逆组合物。 蛋白质底物包括一种或多种蛋白质和粘合改性剂，并且还可以包括增塑剂，碳水化合物或其它改性剂中的一种或多种。 在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。 还提供了用于制备主题组合物的试剂盒。 主题组合物，试剂盒和系统可用于各种不同的应用。

Patent Agency Ranking