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    METHOD AND SYSTEM FOR MODIFYING THE WETTABILITY CHARACTERISTICS OF A SURFACE OF A MEDICAL DEVICE BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND MEDICAL DEVICES MADE THEREBY
    31.
    发明申请
    METHOD AND SYSTEM FOR MODIFYING THE WETTABILITY CHARACTERISTICS OF A SURFACE OF A MEDICAL DEVICE BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND MEDICAL DEVICES MADE THEREBY 审中-公开
    通过应用气体离子束技术和医疗器械改造医疗器械表面的湿度特性的方法和系统

    公开(公告)号：US20090074834A1

    公开(公告)日：2009-03-19

    申请号：US12210018

    申请日：2008-09-12

    Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

    Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

    IPC: A61K9/00

    CPC classification number: B05D3/068 ,  B05D3/104 ,  B05D5/00 ,  H01J2237/0812

    Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

    Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 这些改进可以应用于诸如血管支架的医疗装置的表面，并且可以用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。 可以使用掩模来将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

    FILM AND METHODS OF FORMING SAME
    33.
    发明申请
    FILM AND METHODS OF FORMING SAME 审中-公开
    胶片及其形成方法

    公开(公告)号：US20160091787A1

    公开(公告)日：2016-03-31

    申请号：US14892284

    申请日：2014-05-21

    Applicant: Sean R. KIRKPATRICK ,  Son CHAU ,  EXOGENESIS CORPORATION

    Inventor： Sean R. Kirkpatrick ,  Son T. Chau

    IPC: G03F1/62 ,  B29C59/00 ,  B29C39/20

    Abstract: A film and method of forming a film provides an unmodified starting layer of a starting material, the starting layer having opposed first and second surfaces and an initial thickness, T1, and a modified surface layer of thickness T2 which is less than T1, formed in at least a portion of the second surface, wherein a portion of the modified surface layer is not supported by unmodified starting material removed from the first surface opposite the modified surface layer.

    Abstract translation: 薄膜和薄膜的形成方法提供了未改性的原料起始层，起始层具有相对的第一和第二表面，初始厚度T1和厚度T2小于T1的改性表面层形成于 所述第二表面的至少一部分，其中所述改性表面层的一部分不被从所述改性表面层相对的所述第一表面除去的未改性起始材料支撑。

    DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF
    37.
    发明申请
    DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF 有权
    药物递送系统及其制造方法

    公开(公告)号：US20110029068A1

    公开(公告)日：2011-02-03

    申请号：US12851161

    申请日：2010-08-05

    Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

    Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

    IPC: A61L27/54 ,  B05D3/06 ,  C23C14/02 ,  G21G5/00

    CPC classification number: C23C14/022 ,  A61F2/82 ,  A61F2250/0067 ,  C23C14/221 ,  C23C14/505 ,  H01J37/3171 ,  H01J2237/0812

    Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

    Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 这些改进可以应用于诸如血管支架的医疗装置的表面，并且可以用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。 可以使用掩模来将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

    METHOD AND SYSTEM FOR COATING A SURFACE OF A MEDICAL DEVICE WITH A THERAPEUTIC AGENT AND DRUG ELUTING MEDICAL DEVICES MADE THEREBY
    40.
    发明申请
    METHOD AND SYSTEM FOR COATING A SURFACE OF A MEDICAL DEVICE WITH A THERAPEUTIC AGENT AND DRUG ELUTING MEDICAL DEVICES MADE THEREBY 有权
    用于将医疗装置的表面与治疗剂和药物给药的方法和系统相结合

    公开(公告)号：US20090098186A1

    公开(公告)日：2009-04-16

    申请号：US12243285

    申请日：2008-10-01

    Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

    Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

    IPC: A61K9/70 ,  B05D3/00 ,  A61P43/00 ,  C23C16/54

    CPC classification number: B05D1/02 ,  A61F2/82 ,  A61F2240/001 ,  B05B5/08 ,  B05D3/0493 ,  B05D3/06 ,  B05D3/107 ,  B05D3/145 ,  H01J37/3053 ,  H01J2237/0812 ,  H01J2237/3151

    Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.

    Abstract translation: 通过真空脉冲喷雾技术形成多层药物涂覆的医疗装置，例如可扩张血管药物洗脱支架，其中每层照射以在形成后续层之前提高粘附性和/或药物洗脱性质。 层可能是同质的或不同的药物。 层可以掺入非聚合物洗脱阻滞材料。 层可以与一层或多层非聚合物洗脱阻滞材料交替。 聚合物粘合剂和/或基质不用于形成涂层，而纯药物涂层具有良好的机械和洗脱速率性能。 公开了系统，方法和医疗装置的物品。

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