公开(公告)号：US11504389B2

公开(公告)日：2022-11-22

申请号：US15828931

申请日：2017-12-01

申请人： Sangamo Therapeutics, Inc. ,  The General Hospital Corporation

发明人： Annemarie Ledeboer ,  Bryan Zeitler ,  H. Steve Zhang ,  Sarah DeVos ,  Bradley T. Hyman ,  Susanne Wegmann

IPC分类号： C07H21/04 ,  A61K38/00 ,  A61K31/70 ,  A61K48/00 ,  A61K31/7105 ,  C12N15/86 ,  A61P25/28 ,  A61K38/17 ,  C07K14/47 ,  C12N15/864 ,  A01K67/00

摘要： The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.

公开(公告)号：US11498939B2

公开(公告)日：2022-11-15

申请号：US16332169

申请日：2017-09-14

申请人： ROQUETTE FRERES

发明人： Denis Simon ,  Olaf Haeusler ,  Solène Bock

IPC分类号： A61K31/718 ,  C08B33/00 ,  C07H3/00 ,  A61K31/70 ,  C07H1/00 ,  A23L29/30 ,  A23L29/20 ,  A23L33/125 ,  C08B31/00 ,  A23L33/10 ,  C08L3/12 ,  A23L13/40

摘要： The invention relates to a novel glucose polymer which is particularly useful for administration by the parenteral route, and to the method for the production thereof. The invention also relates to compositions comprising such a glucose polymer, and to the methods for the production thereof. The invention further relates to the use thereof as a medicament, for example as an osmotic agent for peritoneal dialysis.

公开(公告)号：US20220313624A1

公开(公告)日：2022-10-06

申请号：US17826660

申请日：2022-05-27

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Jiajia DONG ,  K. Barry SHARPLESS ,  Jeffery W. KELLY ,  Aleksandra BARANCZAK ,  Wentao CHEN

IPC分类号： A61K31/05 ,  C07C305/26 ,  C07D277/82 ,  C07D295/088 ,  C07D295/185 ,  C07D295/26 ,  A61K47/54 ,  C07D279/08 ,  C07D501/18 ,  A61K31/136 ,  A61K31/14 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4168 ,  A61K31/4245 ,  A61K31/4353 ,  A61K31/439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/485 ,  A61K31/505 ,  A61K31/515 ,  A61K31/53 ,  A61K31/5513 ,  A61K31/56 ,  A61K31/65 ,  A61K31/655 ,  A61K31/70 ,  A61K31/7048 ,  A61K38/31 ,  A61K51/04 ,  C07K1/02 ,  C07K1/113 ,  C07K2/00

摘要： Described herein are compounds comprising a biologically active organic core group with one to five —Z—(X1—S(O)(X2)F)m groups attached thereto, wherein Z is O, NR, or N; X1 is a covalent bond or CH2CH2; m can be 1 or 2 depending on the identity of Z; and X2 is O or NR. In some embodiments, the core group is an amino acid or a protein. In some embodiments the core group is a compound that has therapeutic activity toward a therapeutic target.

公开(公告)号：US11434255B2

公开(公告)日：2022-09-06

申请号：US16333673

申请日：2017-09-18

申请人： LCB PHARMA INC.

发明人： Yvan Guindon ,  Philippe Mochirian ,  Mona Nemer

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/10 ,  A61P31/12 ,  A61P35/00 ,  C07H19/20 ,  C07H19/23 ,  A61P9/00

摘要： The compounds are nucleoside and nucleotide analogues that can be used as cardioprotective agents. The compounds include tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary stereogenic all-carbon centers at the 2′ position and a phosphonate ester at C5′ position.

公开(公告)号：US20220175009A1

公开(公告)日：2022-06-09

申请号：US17678672

申请日：2022-02-23

申请人： SOCIÉTÉ DES PRODUITS NESTLÉ S.A.

发明人： Nora Schneider ,  Jonas Hauser ,  Sean Deoni ,  Tamas Bartfai ,  Jonathan O'Regan

IPC分类号： A23L33/00 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A61K45/06 ,  A24B15/38 ,  A61P25/28 ,  A61K9/00 ,  A61K31/14 ,  A61K31/202 ,  A61K31/519 ,  A61K31/661 ,  A61K31/70 ,  A61K31/714 ,  A61K33/00 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/42

摘要： A synthetic nutritional composition comprising a phospholipid and/or a metabolic precursor and/or metabolite thereof for use to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential, and/or learning potential and/or cognitive functioning in a subject, in particular a formula fed subject.

公开(公告)号：US11344567B2

公开(公告)日：2022-05-31

申请号：US17312404

申请日：2019-12-09

申请人： SHARE GAL RESEARCH AND DEVELOPMENT LTD

发明人： Yehoshua Korchia Maor

IPC分类号： A61K31/70 ,  A01N43/04 ,  A61K31/7048 ,  A61P35/00 ,  A61K36/17

摘要： This invention relates to methods of treating cancer with platanoside and/or isomers thereof or pharmaceutically acceptable salts thereof, particularly treatment of a pancreatic, liver or brain cancer. This invention further relates to methods of treating cancer with platanoside and/or isomers thereof, produced from Ephedra foeminea.

公开(公告)号：US11339410B2

公开(公告)日：2022-05-24

申请号：US16654726

申请日：2019-10-16

申请人： Factor Bioscience Inc.

发明人： Matthew Angel ,  Christopher Rohde

IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50 ,  A61K31/70 ,  A61K35/12

摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US11339183B2

公开(公告)日：2022-05-24

申请号：US17372125

申请日：2021-07-09

申请人： KANCERA AB

发明人： Jan Vågberg ,  Styrbjörn Byström ,  Elisabeth Olsson ,  Mattias Jönsson

IPC分类号： C07F9/6561 ,  A61K9/08 ,  A61K31/685 ,  A61K31/70 ,  A61K45/06

摘要： There is provided a compound of formula I, wherein R1, R2, Q1 and are as defined herein, which compounds are useful in the treatment of diseases and disorders associated with elevated levels of CX3CR1 and/or CX3CL1, in particular acute and/or chronic inflammation, eye diseases, lung diseases, skin diseases, joint and/or bone diseases, autoimmune diseases, cardiovascular diseases, metabolic diseases, brain diseases, neurodegenerative diseases, pain, cancer, liver diseases, kidney diseases, gastrointestinal diseases, human immunodeficiency virus and mood disorders.

公开(公告)号：US11297872B2

公开(公告)日：2022-04-12

申请号：US16061121

申请日：2016-12-13

申请人： NESTEC S.A.

发明人： Nora Schneider ,  Jonas Hauser ,  Sean Deoni ,  Tamas Bartfai ,  Jonathan O'Regan

IPC分类号： A23L33/00 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A61K45/06 ,  A24B15/38 ,  A61P25/28 ,  A61K9/00 ,  A61K31/14 ,  A61K31/202 ,  A61K31/519 ,  A61K31/661 ,  A61K31/70 ,  A61K31/714 ,  A61K33/00 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/42

摘要： A synthetic nutritional composition comprising a phospholipid and/or a metabolic precursor and/or metabolite thereof for use to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential, and/or learning potential and/or cognitive functioning in a subject, in particular a formula fed subject.

公开(公告)号：US11285166B2

公开(公告)日：2022-03-29

申请号：US16435098

申请日：2019-06-07

申请人： B&H Biotechnologies

发明人： Huiru Wang

IPC分类号： A61K31/7012 ,  A61K31/198 ,  A61K31/7008 ,  A61K36/8962 ,  A61K39/00 ,  C40B60/12 ,  A61K31/70

摘要： The present disclosure discloses simple and efficient glycan- or carbohydrate-based processes or methods for the rapid identification of biological markers and therapeutic targets especially glycan-related targets of infectious diseases, cancers, autoimmune diseases, allergies, inflammation, toxicity, obesity and/or other disorders of humans, animals, plants and other organisms. Therefore, novel methods and products for the diagnosis, prevention, and treatment of such diseases obtainable based on these therapeutic targets can be developed.