公开(公告)号：US11767357B2

公开(公告)日：2023-09-26

申请号：US16241410

申请日：2019-01-07

申请人： B & H Biotechnologies, LLC

发明人： Huiru Wang

IPC分类号： C07K16/00 ,  A61K39/42 ,  A61K39/12 ,  C07K16/10 ,  A61K35/16 ,  A61K39/145 ,  A61K39/15 ,  A61K39/235 ,  A61K39/29 ,  A61K47/26 ,  C07K16/08 ,  A61K39/00

CPC分类号： C07K16/1018 ,  A61K35/16 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/235 ,  A61K39/29 ,  A61K39/292 ,  A61K39/42 ,  A61K47/26 ,  C07K16/00 ,  C07K16/081 ,  C07K16/082 ,  C07K16/10 ,  C07K16/109 ,  C07K16/1027 ,  A61K2039/545 ,  C07K2317/21 ,  A61K39/42 ,  A61K2300/00

摘要： The present invention discloses products and the methods of uses of the products for preventing and treating infectious diseases and the disorders or conditions inducible by harmful antibodies. The harmful antibodies are induced during infection, or vaccination, or use of therapeutic antibodies. The products of the present disclosure comprise immunoglobulin products, serum or plasma, specific antibodies to viral pathogens.

公开(公告)号：US11903956B2

公开(公告)日：2024-02-20

申请号：US17572021

申请日：2022-01-10

申请人： B&H BIOTECHNOLOGIES, LLC

发明人： Huiru Wang

IPC分类号： A61K31/7008 ,  A61K45/06 ,  A61K31/198 ,  A61K9/00 ,  A23K20/142 ,  A23L33/17 ,  A23K20/147 ,  A23L33/175 ,  A23L33/10 ,  C07C321/14 ,  C07H15/12 ,  A61K47/02 ,  A61K9/10 ,  A61K9/107 ,  A61K9/08

CPC分类号： A61K31/7008 ,  A23K20/142 ,  A23K20/147 ,  A23L33/10 ,  A23L33/17 ,  A23L33/175 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0095 ,  A61K31/198 ,  A61K45/06 ,  C07C321/14 ,  C07H15/12 ,  A23V2002/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K47/02 ,  A61K31/7008 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00

摘要： Composition and methods for treating infectious and inflammatory diseases using saccharide based products and therapies. Products can be implemented as a nutritional supplement, a food, a feed, a food additive, a feed additive, a therapeutic product, a rehydration salt, or a rehydration solution. The present disclosure relates generally to the fields of compositions and products containing the compositions, and the use of the compositions or the products for preventing and/or treating infectious or inflammatory diseases or conditions in particular gastrointestinal and respiratory diseases (diarrhea and influenza infections) or inflammatory.

公开(公告)号：US11421039B2

公开(公告)日：2022-08-23

申请号：US16785465

申请日：2020-02-07

申请人： B & H Biotechnologies, LLC

发明人： Huiru Wang

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574 ,  A61K45/06

摘要： The invention provides antibodies that specifically bind to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies, as well as polynucleotides, vectors, host cells, and methods useful for production thereof. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent. Still further provided are methods and kits for treating or preventing gastrointestinal disease in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine. Yet further provided are methods and kits for detecting the presence of cancer cells in an individual including an antibody that specifically binds to an epitope containing N-acetylglucosamine and/or N-acetyl-galactosamine.

公开(公告)号：US10597461B2

公开(公告)日：2020-03-24

申请号：US15505064

申请日：2015-08-21

申请人： B & H Biotechnologies, LLC

发明人： Huiru Wang

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574 ,  A61K45/06

摘要： Provided are antibodies that specifically bind to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies, as well as polynucleotides, vectors, host cells, and methods useful for production thereof. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent. Still further provided are methods and kits for treating or preventing gastrointestinal disease in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine. Yet further provided are methods and kits for detecting the presence of cancer cells in an individual including an antibody that specifically binds to an epitope containing N-acetylglucosamine and/or N-acetyl-galactosamine.

公开(公告)号：US11919968B2

公开(公告)日：2024-03-05

申请号：US17812412

申请日：2022-07-13

申请人： B & H Biotechnologies, LLC

发明人： Huiru Wang

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/44 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57488 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  C12N2720/12311 ,  G01N2400/02 ,  G01N2400/40 ,  G01N2800/06

摘要： The invention provides antibodies that specifically bind to an epitope containing N-acetylglucosamine and specifically bind to an epitope comprising N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Further provided are methods for treating gastrointestinal diseases characterized by inflammatory cells in the intestines or colon in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine and specifically binds to an epitope comprising N-acetyl-galactosamine.

公开(公告)号：US20240238410A1

公开(公告)日：2024-07-18

申请号：US18561617

申请日：2021-05-21

申请人： B & H Biotechnologies, LLC

发明人： Huiru Wang

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/145 ,  A61P37/04 ,  C07K16/10 ,  C12N7/00 ,  G01N33/569

CPC分类号： A61K39/215 ,  A61K39/145 ,  A61P37/04 ,  C07K16/1003 ,  C07K16/1018 ,  C12N7/00 ,  G01N33/56983 ,  A61K2039/53 ,  C12N2760/16034 ,  C12N2770/18033 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2469/20

摘要： The invention provides safer vaccines that induce less adverse reactions particular the serious adverse reactions in a host. Also provided are compositions including these safer vaccines, as well as polynucleotides, vectors, host cells, methods, and kits related thereto. Further provided are methods and kits for preventing or treating infectious diseases, infection-relating diseases, and adverse reactions of vaccines in an individual by administering to the individual a safer vaccine that induce less adverse reactions, or by administering to the individual a pathogenic antigen that neutralize pathogenic antibodies. Yet further provided are methods for identification of the presence of pathogenic antibodies inducible by a pathogen or the vaccines relating to the pathogen.

公开(公告)号：US11446328B2

公开(公告)日：2022-09-20

申请号：US15999337

申请日：2017-02-17

申请人： B & H BIOTECHNOLOGIES, LLC

发明人： Huiru Wang

IPC分类号： A61K39/395 ,  A61K35/17 ,  C07K16/30 ,  C07K14/705 ,  C07K16/44 ,  G01N33/574 ,  G01N33/68 ,  C07K14/725 ,  A61P1/18 ,  A61P35/00 ,  C12N15/62 ,  A61K39/00

摘要： It provides antibodies and chimeric antigen receptors (CARs) that specifically bind to an epitope containing N-acetyl-glucosamine and/or N-acetyl-galactosamine, e.g., expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies and/or CARs, as well as polynucleotides, vectors, host cells, methods, and kits related thereto. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, or a T cell comprising a CAR that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent.

公开(公告)号：US20220211733A1

公开(公告)日：2022-07-07

申请号：US17572021

申请日：2022-01-10

申请人： B&H BIOTECHNOLOGIES, LLC

发明人： Huiru Wang

IPC分类号： A61K31/7008 ,  A61K45/06 ,  A61K31/198 ,  A61K9/00 ,  A23K20/142 ,  A23L33/17 ,  A23K20/147 ,  A23L33/175 ,  A23L33/10 ,  C07C321/14 ,  C07H15/12

摘要： Composition and methods for treating infectious and inflammatory diseases using saccharide based products and therapies. Products can be implemented as a nutritional supplement, a food, a feed, a food additive, a feed additive, a therapeutic product, a rehydration salt, or a rehydration solution. The present disclosure relates generally to the fields of compositions and products containing the compositions, and the use of the compositions or the products for preventing and/or treating infectious or inflammatory diseases or conditions in particular gastrointestinal and respiratory diseases (diarrhea and influenza infections) or inflammatory.

公开(公告)号：US11285166B2

公开(公告)日：2022-03-29

申请号：US16435098

申请日：2019-06-07

申请人： B&H Biotechnologies

发明人： Huiru Wang

IPC分类号： A61K31/7012 ,  A61K31/198 ,  A61K31/7008 ,  A61K36/8962 ,  A61K39/00 ,  C40B60/12 ,  A61K31/70

摘要： The present disclosure discloses simple and efficient glycan- or carbohydrate-based processes or methods for the rapid identification of biological markers and therapeutic targets especially glycan-related targets of infectious diseases, cancers, autoimmune diseases, allergies, inflammation, toxicity, obesity and/or other disorders of humans, animals, plants and other organisms. Therefore, novel methods and products for the diagnosis, prevention, and treatment of such diseases obtainable based on these therapeutic targets can be developed.