-
公开(公告)号：US20230270774A1
公开(公告)日：2023-08-31
申请号：US18046327
申请日：2022-10-13
发明人： Annemarie Ledeboer , Bryan Zeitler , H. Steve Zhang , Sarah DeVos , Bradley T. Hyman , Susanne Wegmann
IPC分类号： A61K31/7105 , C12N15/86 , A61P25/28 , A61K38/17 , C07K14/47 , C12N15/864
CPC分类号： A61K31/7105 , C12N15/86 , A61P25/28 , A61K38/1709 , C07K14/4702 , C07K14/4711 , C12N15/8645 , C12N2750/14143
摘要： The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
-
公开(公告)号：US11504389B2
公开(公告)日：2022-11-22
申请号：US15828931
申请日：2017-12-01
发明人： Annemarie Ledeboer , Bryan Zeitler , H. Steve Zhang , Sarah DeVos , Bradley T. Hyman , Susanne Wegmann
IPC分类号： C07H21/04 , A61K38/00 , A61K31/70 , A61K48/00 , A61K31/7105 , C12N15/86 , A61P25/28 , A61K38/17 , C07K14/47 , C12N15/864 , A01K67/00
摘要： The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
-
公开(公告)号：US20180153921A1
公开(公告)日：2018-06-07
申请号：US15828931
申请日：2017-12-01
发明人： Annmarie Ledeboer , Bryan Zeitler , H. Steve Zhang , Sarah DeVos , Bradley T. Hyman , Susanne Wegmann
IPC分类号： A61K31/7105 , C07K14/47 , A61K38/17 , C12N15/864 , A61P25/28
CPC分类号： A61K31/7105 , A61K38/1709 , A61P25/28 , C07K14/4702 , C07K14/4711 , C12N15/86 , C12N15/8645 , C12N2750/14143
摘要： The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
-
公开(公告)号：US20220324928A1
公开(公告)日：2022-10-13
申请号：US17766076
申请日：2020-10-02
发明人： Asa Hatami , Bryan Zeitler , Lei Zhang , David Emanuel Paschon
摘要： The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinson's disease, Lewy body dementia, multiple system atrophy, Alzheimer's disease, and other neurodegenerative diseases.
-
5.发明公开公开(公告)号：US20240018203A1
公开(公告)日：2024-01-18
申请号：US18247093
申请日：2021-10-01
发明人： Asa Hatami , Bryan Zeitler , Lei Zhang , David Emanuel Paschon
CPC分类号： C07K14/4703 , C12N15/86 , A61P25/28 , C07K2319/81 , C12N2750/14143
摘要： The present disclosure provides zinc finger fusion proteins that inhibit expression of alpha-synuclein in the nervous system, and methods of using the proteins to treat Parkinsons disease, Lewy body dementia, multiple system atrophy, Alzheimers disease, and other neurodegenerative diseases.
-
公开(公告)号：US20220064237A1
公开(公告)日：2022-03-03
申请号：US17423063
申请日：2020-01-15
发明人： Galen Carey , Matthew Chiocco , Vivian Choi , Brian Felice , Steven Froelich , Debra Klatte , Jeffrey Miller , David Paschon , Edward Rebar , Bryan Zeitler , Lei Zhang , H. Steve Zhang
摘要： Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).
-
公开(公告)号：US11123443B2
公开(公告)日：2021-09-21
申请号：US16550949
申请日：2019-08-26
发明人： Steven Froelich , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Bryan Zeitler , H. Steve Zhang
IPC分类号： A61K48/00 , C07K14/47 , C12N15/864 , C12N15/86 , C12N5/077 , C12N5/10 , C12N5/0793
摘要： Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
-
公开(公告)号：US20210369872A1
公开(公告)日：2021-12-02
申请号：US17402233
申请日：2021-08-13
发明人： Steven Froelich , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Bryan Zeitler , H. Steve Zhang
IPC分类号： A61K48/00 , C07K14/47 , C12N15/864 , C12N15/86 , C12N5/077 , C12N5/10 , C12N5/0793
摘要： Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
-
公开(公告)号：US20200002390A1
公开(公告)日：2020-01-02
申请号：US16550949
申请日：2019-08-26
发明人： Steven Froelich , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Bryan Zeitler , H. Steve Zhang
摘要： Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
-
公开(公告)号：US20190167815A1
公开(公告)日：2019-06-06
申请号：US16169420
申请日：2018-10-24
摘要： The present disclosure is in the field of modulation of genes involved in rare diseases including for diagnostics and therapeutics for rare diseases such as Angelman's Syndrome, Facioscapulohumeral Muscular Dystrophy (FHMD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD) and Spinal Muscular Atrophy (SMA).
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.026 秒)
