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公开(公告)号：US11920169B2
公开(公告)日：2024-03-05
申请号：US16906845
申请日：2020-06-19
CPC分类号： C12N9/22 , C12N15/52 , C12N15/62 , C12N15/907 , C12Y301/00 , C07K2319/00
摘要： Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.
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公开(公告)号：US11834686B2
公开(公告)日：2023-12-05
申请号：US16545363
申请日：2019-08-20
CPC分类号： C12N9/22 , C12N9/78 , C12N15/11 , C12N15/63 , C12Y305/04001 , C12Y305/04002 , C12N2310/20 , C12N2310/3181 , C12N2310/323 , C12N2310/3231 , C12N2800/80
摘要： Described herein are DNA-editing complexes, particularly DNA-editing complexes that specifically alter a single base pair in target DNA sequence as well as methods of making and using these DNA-editing complexes.
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公开(公告)号：US11725218B2
公开(公告)日：2023-08-15
申请号：US17493655
申请日：2021-10-04
发明人： Yannick Doyon , Jeffrey C. Miller
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C12N9/10 , C12N9/22 , C12N15/52 , C12N15/85 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
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公开(公告)号：US11723952B2
公开(公告)日：2023-08-15
申请号：US17098970
申请日：2020-11-16
CPC分类号： A61K38/1709 , C07K14/4703 , C12N15/907 , C07K2319/00 , C07K2319/70 , C07K2319/71 , C07K2319/81
摘要： Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
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公开(公告)号：US20210188926A1
公开(公告)日：2021-06-24
申请号：US17188764
申请日：2021-03-01
摘要： Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
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公开(公告)号：US20210024957A1
公开(公告)日：2021-01-28
申请号：US17039147
申请日：2020-09-30
发明人： Jeffrey C. Miller , Edward J. Rebar
摘要： Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.
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7.发明申请公开(公告)号：US20200071712A1
公开(公告)日：2020-03-05
申请号：US16674831
申请日：2019-11-05
发明人： W. Michael Ainley , Dmitry Y. Guschin , Matthew Hayden , Daniel Isenegger , John Mason , Jeffrey C. Miller , Joseph F. Petolino , Yidong Ran , Tim Sawbridge , German Spangenberg , Steven R. Webb
摘要： Disclosed herein are methods and compositions for parallel or sequential transgene stacking in plants to produce plants with selected phenotypes.
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公开(公告)号：US10577616B2
公开(公告)日：2020-03-03
申请号：US15943106
申请日：2018-04-02
发明人： Noel Cogan , John Forster , Matthew Hayden , Tim Sawbridge , German Spangenberg , Steven R. Webb , Manju Gupta , W. Michael Ainley , Matthew J. Henry , Jeffrey C. Miller , Dmitry Y. Guschin
摘要： A method of gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a cell, to generate a break in the FAD2 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.
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公开(公告)号：US20190177709A1
公开(公告)日：2019-06-13
申请号：US16281751
申请日：2019-02-21
发明人： Jeffrey C. Miller , Edward J. Rebar
摘要： The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
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公开(公告)号：US20180319864A1
公开(公告)日：2018-11-08
申请号：US16037942
申请日：2018-07-17
发明人： Trevor Collingwood , Laurence J.N. Cooper , Philip D. Gregory , Michael C. Holmes , Jeffrey C. Miller , Edward J. Rebar , Andreas Reik , Fyodor Urnov
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
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