公开(公告)号：US20170327848A1

公开(公告)日：2017-11-16

申请号：US15660072

申请日：2017-07-26

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C07K7/06 ,  C12N15/85 ,  C07K14/47 ,  C12N9/22

CPC分类号： C12N15/907 ,  C07K7/06 ,  C07K14/47 ,  C07K2319/50 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/85 ,  C12Y301/21004

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US20220145307A1

公开(公告)日：2022-05-12

申请号：US17493655

申请日：2021-10-04

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/52 ,  C12N9/10

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US11136599B2

公开(公告)日：2021-10-05

申请号：US16838804

申请日：2020-04-02

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/85 ,  C07K14/47 ,  C07K7/06

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US11725218B2

公开(公告)日：2023-08-15

申请号：US17493655

申请日：2021-10-04

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N9/10 ,  C12N15/52 ,  C12N15/85 ,  C07K14/47 ,  C07K7/06

CPC分类号： C12N15/907 ,  C07K7/06 ,  C07K14/47 ,  C12N9/10 ,  C12N9/22 ,  C12N15/52 ,  C12N15/85 ,  C07K2319/50 ,  C07K2319/80 ,  C07K2319/81 ,  C12Y301/21004

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US10827731B2

公开(公告)日：2020-11-10

申请号：US15990176

申请日：2018-05-25

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon

IPC分类号： C12N15/00 ,  A01K67/027 ,  C12N15/82 ,  C12N15/85

摘要： Disclosed herein are homozygously modified organisms and methods of making and using these organisms.

公开(公告)号：US20180263228A1

公开(公告)日：2018-09-20

申请号：US15990176

申请日：2018-05-25

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon

IPC分类号： A01K67/027 ,  C12N15/85 ,  C12N15/82

摘要： Disclosed herein are homozygously modified organisms and methods of making and using these organisms.

公开(公告)号：US10066242B2

公开(公告)日：2018-09-04

申请号：US15660072

申请日：2017-07-26

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C07K7/06 ,  C12N15/85 ,  C07K14/47 ,  C12N9/22

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US20200231988A1

公开(公告)日：2020-07-23

申请号：US16838804

申请日：2020-04-02

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C07K7/06 ,  C07K14/47 ,  C12N15/85 ,  C12N9/22

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

公开(公告)号：US20180334689A1

公开(公告)日：2018-11-22

申请号：US16055525

申请日：2018-08-06

申请人： Sangamo Therapeutics, Inc.

发明人： Yannick Doyon ,  Jeffrey C. Miller

IPC分类号： C12N15/90 ,  C07K14/47 ,  C12N9/22 ,  C12N15/85 ,  C07K7/06

CPC分类号： C12N15/907 ,  C07K7/06 ,  C07K14/47 ,  C07K2319/50 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/85 ,  C12Y301/21004

摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.